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| TRANSMEMBRANE RECEPTORS AND CHANNELS, 6
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Edited By
A.G. Lee, Department of Biochemistry, University of Southampton, Southampton, England
Included in series
Biomembranes. A Multi-Volume Treatise,
Description
Volume 6 of Biomembranes covers transmembrane receptors and channels. A particularly important role for the membrane is that of passing
messages between a cell and its environment. Part I of this volume covers receptors for hormones and growth factors. Here, as in so many
other areas of cell biology, the application of the methods of molecular biology have led to the recognition of a number of families
of receptors. Typically, such receptors contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular
catalytic domain whose activation, as a result of ligand binding, leads to generation of second messengers within the cell and stimulation
of a range of cytosolic enzymes. An alternative signaling strategy, exploited in particular in the nervous system, is to use ion channels
to allow controlled movement of monovalent (Na+, K+) or divalent (Ca2+) cations in or out of the cell,
resulting in changes in membrane potential or alterations in the intracellular concentration of Ca2+. Part II of this volume
is concerned with these ion channels and with other, often simpler, ion channel systems whose study can throw light on channel mechanism.
Contents
Contents. List of Contributors. Preface (A.G. Lee). Part I Receptors for Hormones and Growth Factors. Insulin Receptor Signaling (D.K.
Sung and I.D. Goldfine). Growth Factor Receptor Tyrosine Kinases (M.J. Fry). Transmembrane Protein Tyrosine Phosphatases (E.C.C. Wong,
T.A. Woodford-Thomas, and M.L. Thomas). Regulation of the Mammalian Adnylyl Cyclases (R.J. Duhe, A.H. Dittman, Z. Wu, and D.R. Storm).
The Prolactin/Growth Hormone/Cytokine Receptor Superfamily (P.A. Kelly, J. Finidori, M. Edery, and M.C. Postel-Vinay). Interleukin-1
Receptors (S.K. Dower and J.E. Sims). Nerve Growth Factor Receptors (R.A. Bradshaw and H. Hondermarck). Part II Channels. Voltage-Gated
Potassium Channels (O. Pongs). Voltage-Gated Calcium Channels (G.Mikala, J.L. Mershon, and A. Schwartz). Cyclic Nucleotide-gated Channels
(P.W. Wohlfart and N.J. Cook). IP3-Sensitive Calcium Channel (K. Mikoshiba, T. Furuichi, and A. Miyawaki). The Ryanodine Receptor (A.G.
Lee). The Dynamic Nature of Gramicidin (D.A. Doyle and B.A. Wallace). The MIP Family of Integral Membrane Channel Proteins (M.H. Saier,
Jr., A. Reizer, and J. Reizer). Ion Channels of Mitochondrial Membranes (C.A. Mannella and K.W. Kinnally). Index.
| Bibliographic details |
Hardbound, 0 pages, publication date: MAR-1997
ISBN-13: 978-1-55938-663-0
ISBN-10: 1-55938-663-0
Imprint: ELSEVIER
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Last update: 4 Sep 2009
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