 |
|
| PHYSIOLOGICAL FUNCTIONS OF CYTOCHROME P450 IN RELATION TO STRUCTURE AND REGULATION, 14
| |
| | |
|
|
To order this title, and for more information, click here
By
C.R. Jefcoate, Department of Pharmacology and Environmental Toxicology Center, University of Wisconsin, Madison, WI, USA
Included in series
Advances in Molecular and Cell Biology, 14
Description
Research on the cytochrome P450 family of genes has traditionally been dominated by forms participating in drug metabolism. This has occurred
in spite of early discovery of steroid hydroxy lase P450 cytochromes in the adrenal gland. More recently, contributions on the characterization
and regulation of P450 cytochromes involved in biosynthetic reactions have been found at the international meetings on cytochrome P450
and in the several books on the field. Key recognition that P450 cytochromes should be recognized in a physiological context was provided
by an international meeting in Jerusalem in 1991 and the subsequent publication of the proceedings in the Journal of Steroid Biochemistry
and Molecular Biology (43, number 8, 92). Like this meeting, this book seeks to place equal weight on the physiological processes
that are controlled by the products of reactions at usually very selective cytochrome P450 forms. Each of the authors was asked to discuss
the molecular regulation of these P450 forms. Each of the authors was asked to discuss the molecular regulation of these P450 forms in
the light of these physiological processes. In some cases the physiological role of the cytochrome P450 and even the natural substrate
are unresolved, but a pattern of strong endocrine regulation is indicative of a hidden function. As more and more low abundance P450
genes are uncovered, the need to address potential physiological activities becomes more pressing. It is almost infinitely more difficult
to identify a physiological substrate than to clone a new form.
Contents
Contents. List of Contributors. Preface (C.R. Jefcoate). P450 Cytochromes and Hormonal Regulation: An Overview (C.R. Jefcoate). Electron
Transfer Proteins of Cytochrome P450 Systems (I. Hanukoglu). The Molecular Structure of P450s: The Conserved and the Variable Elements
(S.E. Graham-Lorence and J.A. Peterson). Diverse Molecular Mechanisms Regulate the Expression of Steroid Hydryxylase Genes Required for
Production of Ligands for Nuclear Receptors (M.R. Waterman and D.S. Keeney). Cytochrome P450scc and Regulation of Cholesterol
Conversion to Steroid Hormones (C.R. Jefacoate). The Regulation of the Formation of Glucocorticoids and Mineralocorticoids In Vivo
(J. LeHoux, H. Bernard, L. Ducharme, A. Lefebvre, D. Shapcott, A. Tremblay, and S. V ronneau). Physiology and Molecular Biology of P450c21
and P450c17 (B. Chung). The Aromatase Reaction (E.R. Simpson, M.S. Mahendroo, M.W. Kilgore, G.D. Means, S.E. Bulun, M.M. Hinshelwood,
and C.R. Mendelson). Regulation of Calcium Metabolism by the Vitamin D Hydroxylases (H.J. Armbrecht, R.K. Nemani, and N. Wongsurawat).
The Regulation of Cholesterol Conversion to Bile Acids (J.Y.L. Chiang and Z.R. Vlahcevic). Eicosanoid Metabolism and Bioactivation by
Microsomal Cytochrome P450 (J.H. Capdevila, D. Zeldin, A. Karara, and J.R. Falck). Steroid Hormones and Other Physiologic Regulators
of Liver Cytochromes P450: Metabolic Reactions and Regulatory Pathways (D.J. Waxman). Index.
| Bibliographic details |
Hardbound, 0 pages, publication date: DEC-1996
ISBN-13: 978-0-7623-0113-3
ISBN-10: 0-7623-0113-9
Imprint: ELSEVIER
|
| Price and Ordering |
Price:
EUR 84.95
USD 169.95
GBP 71.99
|  |
Books and book related electronic products are priced in euro (EUR), and Great Britain Pounds (GBP) and US dollars (USD). EUR prices apply in Europe. GBP prices apply to the UK. USD prices apply to the Americas, Asia Pacific and the rest of the world.
|
See also information about conditions of sale & ordering procedures, and links to our regional sales offices.
|
090/900
Last update: 22 Jan 2010
|
|
| |
| | |
|
|
| |
Home | Elsevier Sites | Privacy Policy | Terms and Conditions | Feedback | Site Map | A Reed Elsevier Company