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| ADVANCES IN MEDICINAL CHEMISTRY, VOLUME 5, 5
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Edited By
A.B. Reitz, Drug Discovery, R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA
S.L. Dax, Drug Discovery, R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA
Included in series
Advances in Medicinal Chemistry,
Description
Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic
chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin
area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the
development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there
is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4,
there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.
Audience
For students, researchers and industrialists in the field of medicinal chemistry.
Contents
Preface (A.B. Reitz, S.L. Dax).
Immunophilins: the next generation (G.S. Hamilton, C. Thomas).
Discovery of ABT-594 and related neuronal
nicotinic acetylcholine receptor modulators as analgesic agents: medicinal chemistry and biology (M.W. Holladay, M.W. Decker). Discovery
and preclinical evaluation of novel dopamine partial agonists as antipsychotic agents (D.J. Wustrow).
Nonpeptide inhibitors of HIV protease
(S. Hagen et al.).
| Bibliographic details |
Hardbound, 0 pages, publication date: DEC-1999
ISBN-13: 978-0-7623-0593-3
ISBN-10: 0-7623-0593-2
Imprint: ELSEVIER
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USD 114
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Last update: 4 Sep 2009
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