Edited by
B.E. Maryanoff, Drug Discovery, R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA
A.B. Reitz, Drug Discovery, R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA
Description
Volume 4 of
Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including
molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity
correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop,
helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of
the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new
drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation
of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin
receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved
in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as
a potential treatment for human cancers.
Included in series
Advances in Medicinal Chemistry
Audience:
For students, researchers and industrialists in the field of medicinal chemistry
