To order this title, and for more information, click here
Edited By B.E. Maryanoff, Drug Discovery, R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA A.B. Reitz, Drug Discovery, R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA
Description Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including
molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity
correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop,
helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of
the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new
drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation
of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin
receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved
in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as
a potential treatment for human cancers.
Audience
For students, researchers and industrialists in the field of medicinal chemistry
Contents Preface (B.E. Maryanoff, A.B. Reitz).
Novel peptide mimetic building blocks and strategies for efficient lead finding (D. Obrecht et
al.).
Recent advances in the medicinal chemistry of taxoid anticancer agents (I. Ojima et al.). Synthesis and structure-activity
relationships of peroxidic antimalarials based on artemisinin (M.A. Avery et al.).
Design of compound libraries for detecting
and pursuing novel small molecule leads (A.M. Ferguson, R.D. Cramer).
A theoretical model of the human thrombin receptor (PAR-1), the
first known protease-activated G-protein-coupled receptor (M.P. Beavers et al.).
Farnesyl transferase inhibitors: design of
a new class of cancer chemotherapeutic agents (T.M. Williams, C.J. Dinsmore).
Books and book related electronic products are priced in US dollars (USD), euro (EUR), and Great Britain Pounds (GBP). USD prices apply to the Americas and Asia Pacific. EUR prices apply in Europe and the Middle East. GBP prices apply to the UK and all other countries.
Home | Elsevier Sites | Privacy Policy | Terms and Conditions | Feedback | Site Map | A Reed Elsevier Company