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| INSULIN RESISTANCE, METABOLIC DISEASES AND DIABETIC COMPLICATIONS
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 Proceedings of the 7th European Symposium on Metabolism, Padova, 30 September - 3 October, 1998
Edited by
G. Crepaldi, University of Padua-Policlinico, Department of Internal Medicine, Via Giustiniani, 2, 32128 Padova, Italy
A. Tiengo, University of Padua-Policlinico, Department of Clinical Medicine, Via Giustiniani, 2, 32128 Padova, Italy
S. Del Prato, University of Padua-Policlinico, Department of Clinical Medicine, Via Giustiniani, 2, 32128 Padova, Italy
Included in series
International Congress, 1177
Description
Insulin resistance was recognized as a feature and a pathogenic mechanism in pathological states such as type 2 diabetes mellitus and
obesity. More recently, however, it has become apparent that an impairment in insulin action is shared by a variety of conditions not
necessarily associated with diabetes or obesity. These conditions include essential hypertension, dyslipidemia, endothelial dysfunction,
hyperuricemia and many others. Moreover, these conditions tend to cluster with insulin resistance prompting the definition of the "Syndrome
of Insulin Resistance." This association has been recently recognized by the WHO as a tentative definition of diagnostic criteria was
proposed. This book provides a comprehensive information on the role of insulin resistance as prognostic parameter.
This book collects
the contribution of the most eminent experts in the field of genetics, epidemiology, physiopathology, complications and therapy of insulin
resistance. As such, it provides a comprehensive and updated evaluation of the possible role of insulin resistance in pathogenesis of
a cluster of major risk factors for cardiovascular disease.
The book will be of interest for all those professionals who would like
to find a broad, though specific, overview on several aspects of insulin resistance as a possible pathogenetic mechanism.
The book
represents the most comprehensive review of genetics, epidemiology, physiopathology, complications and therapy of insulin resistance.
Audience
Professionals in the field of diabetes and cardiology
Contents
Epidemiology.
Insulin resistance and systematic atherosclerosis
(G. Howard et al.).
The Diabetes Intervention Study: impact
of quality of risk factor control on coronary heart disease and mortality
(M. Hanefeld, S. Fischer).
Glucose, insulin and atherosclerosis:
Lesson from the Bruneck Study
(E. Bonora et al.).
The plurimetabolic syndrome in the European population: the experience of
the European Group on Insulin Resistance (EGIR)
(S. Del Prato, A. Maran, H. Beck-Nielsen).
Genetics.
Result of 10-years genetic
studies in French families with type 2 diabetes
(P. Froguel).
ACE genotype and diabetic nephropathy
(M. Marre).
Apolipoprotein E. gene
polymorphism, vascular complications and nephropathy in NIDDM
(C. Gabelli et al.).
The atherogenic dyslipidemia of visceral
obesity: need for preventive endocrinology
(J.-P. Després).
Molecular and Cellular Markers of Insulin Resistance and Diabetic
Complications.
Nitric oxide and arginine
(P. Vallance).
Protein kinase C activation and the formation of diabetic vascular complications
(G.L. King, H. Wakasaki).
Molecular basis of insulin receptor activation, signal transduction and signalling specificity
(P.A. Holst,
P. De Meyts).
Regulation of metabolic gene expression by glucose
(J. Girard, F. Foufelle, P. Ferre).
Insulin Resistance, Endothelium
and Diabetic Complications.
Endothelium and diabetes. Evidences for a relationship between metabolic control and inappropriate nitric
oxide production
(A. Avogaro et al.).
Effect of different lipoprotein fractions on nitric oxide and superoxide production in
endothelial cells
(L. Vergnani et al.).
Renal Complications.
Diabetic nephropathy in IDDM and NIDDM: functional studies
(R. Mangili).
Diabetic nephropathy in Type 1 and Type 2 diabetes: structural studies
(A. Saller et al.).
Cellular markers for
diabetic nephropathy
(R. Trevisan et al.).
Atherosclerotic Complications.
Dyslipidemia in diabetes: clinical importance
of lipoprotein heterogeneity
(M.-R. Taskinen, R. Malmström, C.J. Packard).
Heterogeneity of triglyceride-rich lipoproteins in the
postprandial state
(F. Karpe).
The role of glycation in diabetic complications
(A. Lapolla, P. Traldi, D. Fedele).
Oxidative stress and
diabetic complications
(A. Ceriello).
Triglycerides increase the biosynthesis of plasminogen activator inhibitor type I: focus on their
mechanism of action
(E. Tremoli et al.).
Altered fatty acid partitioning by PPAR activators improves glucose homeostatis; a
case of PPARα and γ coagonists
(J. Auwerx).
Prevention of Complications.
The role of antihypertensive treatment in CHD
prevention
(L. Argenziano et al.).
Antihypertensive therapy and cardiovascular complications
(Ph. Passa).
Pharmacologic inhibition
of the renin-angiotensin system and diabetic nephropathy
(G. Deferrari et al.).
Calcium channel blockers and incipient diabetic
nephropathy
(M. Dalla Vestra et al.).
Prevention of diabetic complications. Diet and cardiovascular disease: the epidemiological
evidence
(A. Bonanome, A. Pagnan).
Effects of dietary fat and carbohydrate on insulin resistance
(G. Riccardi, G. Annuzzi).
Secondary
prevention of coronary heart disease in diabetes: a subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)
(K. Pyörälä).
HMG-CoA reductase inhibitors in atherosclerosis
(B.M. Buckley).
Diabetes and atherosclerosis: a lipoprotein perspective
(G. Steiner).
Metformin
(D. Giugliano).
Metformin and the treatment of insulin resistance syndrome - The BIGPRO Studies
(M.A. Charles, E. Eschwège,
BIGPRO Study Group).
Mechanism of action of thiazozidinediones in type 2 diabetes
(K.Levin, H. Beck-Nielsen).
Leptin: a perspective for
the weight control problem
(M. Maffei).
Carnitine system and insulin resistance
(G. Peluso et al.).
Index of authors.
| Bibliographic details |
Hardbound, 286 pages, publication date: JUL-1999
ISBN-13: 978-0-444-50022-9
ISBN-10: 0-444-50022-7
Imprint: EXCERPTA MEDICA
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| Price and Ordering |
Price:
EUR 131
GBP 87.50
USD 131
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Last update: 26 Sep 2008
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