MOLECULAR MECHANISMS TO REGULATE THE ACTIVITIES OF INSULIN-LIKE GROWTH FACTORS
Proceedings of the 4th International Symposium on Insulin-like Growth Factors, Tokyo International Forum, Tokyo, Japan, 21-24 October 1997
Edited by K. Takano N. Hizuka, Department of Internal Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162, Japan S.-I. Takahashi, Department of Allied Animal Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
Description The 4th International Symposium on Insulin-like Growth Factors (IFGs) in Tokyo was held on the 40th anniversary of the discovery of sulfation
factor by Salmon and Daughaday. In these forty years, the name sulfation factor has been renamed twice; in 1972 it was renamed somatomedin
and in 1987 to insulin growth-like factors, according to the function and structure. The existence of binding proteins was described
in the '70s and since then ten different kinds have been reported.
The purpose of this symposium was to again bring researchers throughout
the world together to facilitate the exchange of their knowledge and most recent findings. At the symposium, there were thirteen symposia
of invited presentations on selected topics, two special lectures and three workshops addressing methodologies critical to research progress.
One hundred and sixty-six free communications were presented at the poster session. Twenty-six selected papers were presented in their
respected symposia.
Since the last symposia held in 1994, there has been considerable progress in the research of IGFs, especially
on gene knockout models of IGF, insulin and their receptors, IGFBP proteolysis, IGF-independent IGFBP action, and IGF specific signaling
pathway distinguished from insulin signaling pathwayt, using molecular and cellular biological techniques. Advances in other research
fields also shed light on molecular mechanisms to regulate the activities of IGF at various steps. All of these interesting presentations
by participants are included in this book. In understanding all of these complicated mechanisms it will soon be possible to apply IGFs
to various diseases in the near future. Also included is the nomenclature of IGFBPs discussed during the symposium.
This volume will
continue to contribute to the elucidation of physiological roles of IGF and their related proteins until the Fifth International Symposium
in 1999.
Contents Preface. Acknowledgements. List of committee members.
A. From Sulphation Factor to IGF-1, 40 Years of Research on the Regulation of
Cartilage Growth (W.H. Daughaday).
B. Diabetes and the Heart: Physiological and Therapeutic Aspects of IGF-1 (E.R. Froesch et al.).
C. Regulation of Gene Expression and Synthesis of IGF and IGFBP. Methods to analyze tissue-specific promoters
for IGF and IGFBP gene expression (C.T. Roberts). Involvement of AP-1-like motifs in the IGF-1 gene regulation (Y. Kajimoto et al.).
Insulin-like growth factor binding protein-1 gene activation in human endometrium (L. Tseng et al.). Regulation of ALS gene
expression by growth hormone (Y. Boisclair et al.). Insulin-like growth factor gene targeting (W. Won, L. Powell-Braxton).
Genetic disruption of IGF binding proteins (J.E. Pintar et al.). Targeted mutations of insulin and IGF-1 receptors in mice
(D. Accili et al.).
D. Regulation of IGFBP Action. Methods to detect and analyze modified insulin-like growth factor
binding proteins (S.M. Firth). IGFBP proteases - physiology/pathophysiology (J.M.P. Holly et al.). Proteolytic fragments of
IGF binding protein-3: physiological significance (M. Binoux et al.). IGFBP regulation by proteases (C.A. Conover). Regulation
of insulin-like growth factor I actions by insulin-like growth factor binding protein-5 (D.R. Clemmons et al.). IGF-independent
actions of IGFBPs (Y.Oh et al.). The regulation and actions of ALS (P.J.D. Delhanty).
E. Tissue-specific Regulation of IGF
Activity. Insulin-like growth factors in the development of the pancreas ( D.J. Hill et al.). The early embryonic neuroretina:
a CNS site of production and action of (pro)insulin and IGF-1 (F. de Pablo et al.). IGF-1 and uterine growth (O.O. Adesanya
et al.). Bone morphogenetic proteins and IGF systems (S. Mohan, D.J. Baylink). Regulation of IGF and IGFBP gene expression
in bone (R. Okazaki). The IGF system in the ovary (G.F. Erikson et al.). The roles of IGFs and IGFBP-1 in non-pregnant human
endometrium and at the maternal: placental interface during human pregnancy (L.C. Giudice). The prostatic IGF system: new levels of complexity
(A. Grimberg et al.). Evolutionary aspects of the IGF system (C. Collet et al.). The IGF system in the brain - response
to injury and therapeutic potential (P.D. Gluckman et al.). The IGF-1 paradox in cerebellar granule cells: prevention of death
via apoptosis opens the route to death via glutamate-triggered necrosis (P. Calissano et al.). IGFs and IGFBPs in organogenesis:
development of normal and abnormal kidneys (V.K.M. Han, D.G. Matsell). Expression of IGF-1 and IGFBPs in rat kidney and the effect of
GH and nutrition (S. Kobayashi, H. Nogami). Regulatory role of interleukin 1β and nitric oxide on vascular smooth muscle cell proliferation
in primary culture (T. Bourcier, A. Hassid).
F. IGF Signal Transduction. The yeast two-hybrid system to investigate IGF-1 receptor
signal transduction (R.W. Furlanetto et al.). Signal transduction mechanism of insulin and growth hormone (T. Kadowaki et
al.). The insulin-like growth factor-I receptor and cellular signalling: implications for cellular proliferation and tumorigenesis
(D. LeRoith et al.). Differences between insulin and IGF-1 signaling (P. Nissley et al.).
G. IGF in Diseases and
a Possible Clinical Application of IGF. The multiple roles of the IGF-1 receptor in cell growth (R. Baserga et al.). Role
of IGF-II in Wilms tumourigenesis and overgrowth disorders (A.E. Reeve). The IGF system in breast cancer ( D. Yee et al.).
rhIGF-1/IGFBP-3 (SomatoKine) therapy for the treatment of osteoporosis (S. Adams et al.). Role of insulin-like growth factor-I
in gastrointestinal growth and repair (C.-B. Steeb et al.). Metabolic actions of insulin-like growth factors (J. Zapf et
al.). IGF-1 treatment during early HIV infection: immunological and hormonal effects (F. Sattler et al.). IGF-1 treatment
of growth hormone insensitivity (R.G. Rosenfeld). IGF-1 therapy for patients with extreme insulin resistance syndromes (M. Kasuga).
Insulin-like growth factor-1 (IGF-1): therapeutic potential in neuromuscular and other neurological diseases (J.M. Farah Jr). Directions
for research into the insulin-like growth factor system as the millenium approaches: closing remarks to the IVth IGF Symposium (E.M.
Spencer, R. Sapolsky). Index of authors.
Books and book related electronic products are priced in US dollars (USD), euro (EUR), and Great Britain Pounds (GBP). USD prices apply to the Americas and Asia Pacific. EUR prices apply in Europe and the Middle East. GBP prices apply to the UK and all other countries.
Proceedings of the 4th International Symposium on Insulin-like Growth Factors, Tokyo International Forum, Tokyo, Japan, 21-24 October 1997
