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| THE ROLE OF ADENOSINE IN THE NERVOUS SYSTEM
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 Proceedings of the International Symposium on Adenosine in the Nervous System, Kobe, Japan, 13-16 July 1996
Edited by
Y. Okada, Department of Physiology, School of Medicine, Kobe University, Kobe 650, Japan
Included in series
International Congress, 1140
Description
On the basis of significant advances in the molecular, cellular and behavioural fields in the past decade, there has been a great increase
in our knowledge of the biological action of adenosine and its related compounds in the nervous system.
These proceedings survey the
expansion of ideas and development of potential applications and bring together the up-to-date knowledge and in-depth understanding of
adenosine, a highly significant neuromodulator. The objectives of the symposium were not "encyclopedic", but rather "catalytic". Various
fields of research from molecular biology to clinical therapeutics including several topics on the extraneuronal action of adenosine
are covered.
Contents
Part I. Reviews of Current Topics.
New nomenclature for adenosine and P2 receptors (B.B. Fredholm). Adenosine and neurotransmitter
release: inhibition and facilitation (J.A. Ribeiro et al.). Excitatory effects of adenosine on neurotransmission in the central
nervous system (Y. Okada, H. Hirai). Adenosine in cerebral ishemic injury: both friend and foe (J.W. Phillis). Adenosine A2A
receptors and the actions of caffeine (B.B. Fredholm et al.).
Part II. Recent Advances in the Adenosine Study. 1. Adenosine
action on different regions in the nervous system.
Adenosine plays a key role on neuromuscular transmission to adjust the modulatory
pattern (cholinergic vs peptideric) to the conditions of motor nerve stimulation (P. Correia-de-Sá, M.A. Timótao,
J.A. Ribeiro). Cyclic AMP-dependent and independent mechanisms for presynaptic modulation of GABAergic transmission in the cerebellar
cortex (S. Konishi, H. Mitoma). Inhibitory effect of adenosine agonists and propentofylline on the proliferation and transformation of
cultured microglia (Y. Nakamura et al.). A slow depolarizing response induced by ATP in the neurons of bullfrog sympathetic
ganglia (K. Somei et al.). Activation of adenosine A1 and A2 receptors differentially modulates acetylcholine
release from electric organ synaptosomes of Japanese electric ray Narke japonica (Y. Kirino et al.).
2. Studies
in hippocampus.
Endogenous adenosine attenuates long-term depression in the hippocampus (A. de Mendonça, J.A. Ribeiro). The
roles of endogenous adenosine, acting via A1 and A2 receptors, in the induction and reversal of long-term potentiation
in guinea pig hippocampal slices CA1 neurons (S. Fujii et al.). Release of ATP and adenosine and formation of extracellular
adenosine in hippocampus (R.A. Cunha). Adenosine activates the K+ channel and enhances cytosolic Ca2+ release via
a P2Y purinoceptor in hippocampal neurons (T. Nishizaki et al.). PIA, an adenosine A1 receptor agonist,
reduces high K+-evoked GABA release from in vivo rat hippocampus (J. Hada et al.). Role of adenosine upon
high K+-evoked spreading depression and glutamate release from in vivo rat hippocampus (T. Kaku et al.).
Modulation of the transsynaptic response in human hippocampus by adenosine (K. Kato). Chloroadenosine- and nitric oxide-mediated hippocampal
neurotoxicity in vitro (D. Janigro et al.). Adenosine A1 receptors in CA2 region are involved in inhibitory
modulation of signal transmission from CA1 to CA3 in rat hippocampal slices (Y. Sekino, T. Ochiishi, K. Obata).
3. Adenosine receptors,
transporters and metabolism.
Functional negative interaction between adenosine (A1) and GABA (GABAA) during
hypoxia in the rat hippocampus (A.M. Sebastião et al.). PET imaging of adenosine A1 receptor in anesthetized
monkey brain (S. Wakabayahi et al.). Typical and 'atypical' adenosine A2A receptors in CNS (R.A. Cunha). In vivo
evaluation of [11C]F17837, a selective adenosine A2a antagonist for mapping of CNS adenosine A2a receptor
(J. Noguchi et al.). Evidence that A2A-adenosine receptors in the rostral basal forebrain are involved in the regulation
of sleep (S. Satoh et al.). Functions of adenosine A2A receptors in striatum (Y. Kuwana et al.). Characterization
of P3 purinoceptor-like protein purified from rat brain membranes (Y. Saitoh, H. Nakata). Sodium-dependent nucleoside transporters
in rat brain (F.E. Parkinson, S.L. Borgland, C.M. Anderson). Cell initiated regulation of adenylyl cyclases via adenine 3'-nucleotides
(R.A. Johnson, I. Shoshani, L. Desaubry).
Possibilities for clinical applications.
Anti-apoptotic impact of adenosine and its
nucleotides on the cultured rat cerebellar granule neurons (H. Amino, H. Saito, N. Nishiyama). Microdialysis of neocortical adenosine
purines during normovolemic hemodilution and systemic hypoxemia in swine (P.D. Mongan et al.). Prevention of development of
dependence to morphine by using cyclic AMP-related compounds in mice (T. Nabeshima et al.). Is adenosine a mediator of vasodilation
in brain blood flow autoregulation of the lamb? (J.T. O'Neill, R. Bünger). Adenosine and sleep apnea (D. Carley, M. Radulovacki). Adenosine A2 receptor occupancy promotes fibroblast and endothelial cell migration and wound healing (M.C. Montesinos et
al.). A selective adenosine kinase inhibitor GP3269, as a novel approach to anticonvulsant therapy (J.B. Wiesner et al.).
Bibliographic & ordering Information
Hardbound, 290 pages, publication date: OCT-1997
ISBN-13: 978-0-444-82643-5
ISBN-10: 0-444-82643-2
Imprint: EXCERPTA MEDICA
Price: Order form
USD 156
GBP 104
EUR 156
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Last update: 5 Aug 2008
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