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| ALKALOIDS: CHEMICAL AND BIOLOGICAL PERSPECTIVES, VOLUME 11, 11
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Edited By
S.W. Pelletier, Institute for Natural Products Research, Chemistry Building, The University of Georgia, Athens, Georgia 30602-2556, USA
Included in series
Alkaloids: Chemical and Biological Perspectives, 11
Description
Volume 11 of this series presents five timely reviews on current research on alkaloids. Chapter 1 by Paul L. Schiff, Jr. is a monumental
survey of research that has been carried out over the past decade on the Thalictrum alkaloids. Forty-six new alkaloids are described
from fifteen species of the genus Thalictrum, as well as 116 alkaloids of known structure from thirty-six species and subspecies
of the genus. The chapter includes discussions of isolation and structure elucidation, analysis, biosynthesis, cell culture, and pharmacology.
Also featured are inclusive compilations of botanical sources, alkaloids by alkaloid types, and calculated molecular weights of the Thalictrum
alkaloids.
Chapter 2 by Giovanni Appendino provides a fascinating treatment of Taxine, a collective name referring to a mixture of
diterpenoid alkaloids from the yew tree (genus: Taxus). Taxine is responsible for the toxic properties of the yew tree that
has been documented in historical and fictional literature, from Julius Caesar to Shakespeare, and from Agatha Christie to T.S. Eliot.
The chapter treats the history, isolation techniques, structure elucidation, chemistry, and pharmacology of Taxine.
Chapter 3 by Mary
D. Menachery surveys the alkaloids of South American Menispermaceae (moonseed family). Many different structural types are included in
this family. The alkaloid-bearing plants are woody-vines, shrubs, or small trees. Several of these species possess potent curare activity.
The chemistry as well as pharmacology of these alkaloids is summarized.
Chapter 4 by Russell J. Molyneux, Robert J. Nash, and Naoki
Asano treats the chemistry and biological activity of the calystegines and related nortropane alkaloids. These polyhydroxylated
bicyclic alkaloids represent another class of compounds that inhibit glycosidases, producing profound effects in biological systems by
disrupting the essential cellular function of glycoprotein processing.
Chapter 5, a related chapter by Robert J. Nash, Naoki Asano,
and Alison A. Watson, reviews polyhydroxylated alkaloids that inhibit glycosidases. Topics covered include distribution, ecological significance
and toxicity, isolation, synthesis, and biosynthesis.
Audience
For scientists working in the fields of natural product chemistry, medicinal chemistry, pharmacology and biochemistry.
Contents
Chapter headings:
The Thalictrum Alkaloids: Chemistry and Pharmacology (1985 -1995) (P. L. Schiff, Jr.). Taxine
(G. Appendino). The Alkaloids of South American Menispermaceae (M.D. Menachery). The Chemistry and Biological Activity of Calystegines
and Related Nortropane Alkaloids (R.J. Molyneux et al.). Polyhydroxylated Alkaloids that Inhibit Glycosidases (R.J.
Nash et al.). Subject Index. Organism Index.
| Bibliographic details |
Hardbound, 0 pages, publication date: DEC-1996
ISBN-13: 978-0-08-042797-3
ISBN-10: 0-08-042797-9
Imprint: PERGAMON
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Last update: 10 Sep 2009
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