FERMENTATION AND BIOCHEMICAL ENGINEERING HANDBOOK, 2ND ED.
Principles, Process Design and Equipment To order this title, and for more information, click here Second Edition
By Henry C. Vogel Celeste C. Haber
Description This is a well-rounded handbook of fermentation and biochemical engineering presenting techniques for the commercial production of chemicals
and pharmaceuticals via fermentation. Emphasis is given to unit operations fermentation, separation, purification, and recovery. Principles,
process design, and equipment are detailed. Environment aspects are covered.
The practical aspects of development, design, and operation
are stressed. Theory is included to provide the necessary insight for a particular operation. Problems addressed are the collection of
pilot data, choice of scale-up parameters, selection of the right piece of equipment, pinpointing of likely trouble spots, and methods
of troubleshooting.
The text, written from a practical and operating viewpoint, will assist development, design, engineering and production
personnel in the fermentation industry. Contributors were selected based on their industrial background and orientation. The book is
illustrated with numerous figures, photographs and schematic diagrams.
Audience
Engineers and scientists in the chemical and pharmaceutical industries who use fermentation techniques in production. Development, design,
engineering and production personnel in the fermentation industry.
Contents 1. Fermentation Pilot Plant
1.1 Microbial Fermentation
1.2 Mammalian Cell Culture System
1.3 Bioreactors for Plant Cell Tissue
and Organ Cultures
2. Fermentation Design
2.1 Introduction
2.2 Fermentation Department, Equipment and Space Requirements
2.3 General
Design Data
2.4 Continuous Sterilizers
2.5 Fermenter Cooling
2.6 The Design of Large Fermenters (Based on Aeration)
2.7 Trouble
Shooting in a Fermentation Plant
3. Nutritional Requirements in Fermentation Processes
3.1 Introduction
3.2 Nutritional Requirements
of the Cell
3.3 The Carbon Source
3.4 The Nitrogen and Sulfur Source
3.5 The Source of Trace and Essential Elements
3.6 The Vitamin
Source and Other Growth Factors
3.7 Physical and Ionic Requirements
3.8 Media Development
3.9 Effect of Nutrient Concentration
on Growth Rate
4. Statistical Methods for Fermentation Optimization
4.1 Introduction
4.2 Traditional One-Variable-at-a-Time Method
4.3 Evolutionary Optimization
4.4 Response Surface Methodology
4.5 Advantages of RSM
4.6 Disadvantages of RSM
4.7 Potential
Difficulties with RSM
4.8 Methods to Improve the RSM Model
4.9 Summary
5. Agitation
5.1 Theory and Concepts
5.2 Pumping Capacity
and Fluid Shear Rates
5.3 Mixers and Impellers
5.4 Baffles
5.5 Fluid Shear Rates
5.6 Full-Scale Plant Design
5.7 Full-Scale
Process Example
5.8 The Role of Cell Concentration Mass Transfer Rate
5.9 Some Other Mass Transfer Considerations
5.10 Design Problems
in Biochemical Engineering
5.11 Solution-Fermentation Problems
6. Filtration
6.1 Introduction
6.2 Cake Filtration
6.3 Theory
6.4 Particle Size Distribution
6.5 Optimal Cake Thickness
6.6 Filter Aid
6.7 Filter Media
6.8 Equipment Selection
6.9 Continuous
vs. Batch Filtration
6.10 Rotary Vacuum Drum Filter
6.11 Nutsches
6.12 H_-Hybrid Filter Press
6.13 Manufacturers
7. Cross-Flow
Filtration
7.1 Introduction
7.2 Cross-Flow vs. Dead End Filtration
7.3 Comparison of Cross-Flow with Other Competing Technologies
7.4 General Characteristics of Cross-Flow Filters
7.5 Operating Configurations
7.6 Process Design Aspects
7.7 Applications Overview
8. Solvent Extraction
8.1 Extraction Concepts
8.2 Distribution Data
8.3 Solvent Selection
8.4 Calculation Procedures
8.5 Drop
Mechanics
8.6 Types of Extraction Equipment
8.7 Selection of Equipment
8.8 Procedure Summary
8.9 Additional Information
9. Ion
Exchange
9.1 Introduction
9.2 Theory
9.3 Ion Exchange Materials and Their Properties
9.4 Laboratory Evaluation of Resin
9.5
Process Considerations
9.6 Ion Exchange Operations
9.7 Industrial Chromatographic Operations
10. Evaporation
10.1 Introduction
10.2 Evaporators and Evaporation Systems
10.3 Liquid Characteristics
10.4 Heat Transfer in Evaporators
10.5 Evaporator Types
10.6 Energy Considerations for Evaporation System Design
10.7 Process Control Systems for Evaporators
10.8 Evaporator Performance
10.9 Heat Sensitive Products
10.10 Installation of Evaporators
10.11 Troubleshooting Evaporation Systems
11. Crystallization
11.1 Introduction
11.2 Theory
11.3 Crystallization Equipment
11.4 Data Needed for Design
11.5 Special Considerations for Fermentation
Processes
11.6 Method of Calculation
11.7 Troubleshooting
11.8 Summary
11.9 American Manufacturers
12. Centrifugation
12.1
Introduction
12.2 Theory
12.3 Equipment Selection
12.4 Components of the Centrifuge
12.5 Sedimentation Centrifuges
12.6 Tubular-Bowl
Centrifuges
12.7 Continuous Decanter Centrifuges (with Conveyor)
12.8 Disk Centrifuges
12.9 Filtering Centrifuges vs. Sedimentation
Centrifuge
12.10 Filtering Centrifuges
12.11 Vertical Basket Centrifuges
12.12 Horizontal Peeler Centrifuges
12.13 Inverting
Filter Centrifuge
12.14 Maintenance: Centrifuge
12.15 Safety
13. Water Systems for Pharmaceutical Facilities
13.1 Introduction
13.2 Scope
13.3 Source of Water
13.4 Potable Water
13.5 Water Pretreatment
13.6 Multimedia Filtration
13.7 Water Softening
13.8 Activated Carbon
13.9 Ultraviolet Purification
13.10 Deionization
13.11 Purified Water
13.12 Reverse Osmosis
13.13 Water
for Injection
13.14 Water System Documentation
14. Sterile Formulations
14.1 Introduction
14.2 Sterile Bulk Preparation
14.3
Isolation of Sterile Bulk Product
14.4 Crystallization
14.5 Filtering/Drying
14.6 Milling/Blending
14.7 Bulk Freeze Drying
14.8 Spray Drying
14.9 Equipment Preparation
14.10 Validation
14.11 Filling Vials with Sterile Bulk Materials
14.12 Environment
14.13 Equipment List
15. Environmental Concerns
15.1 Environmental Regulations and Technology
15.2 Laws, Regulations and Permits
15.3 Technology (Waste Water)
15.4 Waste Water Treatment Strategy
15.5 Air (Emission of Concern)
15.6 Selecting a Control Technology
15.7 Volatile Organic Compound (VOC) Emissions Control
15.8 Particulate Control
15.9 Inorganics
16. Instrumentation and Control
Systems
16.1 Introduction
16.2 Measurement Technology
16.3 Biosensors
16.4 Cell Mass Measurement
16.5 Chemical Composition
16.6 Dissolved Oxygen
16.7 Exhaust Gas Analysis
16.8 Measurement of pH
16.9 Water Purity
16.10 Temperature
16.11 Pressure
16.12 Mass
16.13 Mass Flow Rate
16.14 Volumetric Flow Rate
16.15 Broth Level
16.16 Regulatory Control
16.17 Dynamic Modeling
16.18 Multivariable Control
16.19 Artificial Intelligence
16.20 Distributed Control
17. Drying
17.1 Indirect Drying
17.2 Direct
Drying
18. Plant Design and Cost
18.1 Introduction to the Capital Project Life Cycle
18.2 Conceptual Phase
18.3 Preliminary Design
Phase
18.4 Detail Design Phase
18.5 Construction Phase
18.6 Start-up Phase
18.7 The Fast Track Concept
18.8 The Impact of Validation
18.9 Introduction to the Costing of a Capital Project
18.10 Order of Magnitude Estimate
18.11 Approval Grade Estimate
18.12 Control
Estimate
18.13 Dynamics of an Estimate
Bibliographic details
Hardbound, 828 pages, publication date: DEC-1996
ISBN-13: 978-0-8155-1407-7
ISBN-10: 0-8155-1407-7
Imprint: WILLIAM ANDREW
Price and Ordering
Price: GBP 117.99 USD 195 EUR 138.95
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