Edited by
A.L. Burlingame, Dept Pharmaceutical Chemistry, University of California, San Francisco, USA
Description
This volume describes and integrates the techniques and fundamentals of more than a decade of revolutionary advances in both chromatographic
and mass spectrometric technologies that have enabled the direct investigation of biomacromolecules per se and have provided the analytical
power base to usher in the new fields of proteomics and systems biology.
It also covers new biophysical applications such as H/D
exchange for study of conformations, protein-protein and protein-metal and ligand interactions. Finally it describes atto-to-zepto-mole
quantitation of 14C and 3H by accelerator mass spectrometry.
Included in series
Methods in Enzymology
Audience:
Biochemists, biophysicists, cell biologists, molecular biologists, geneticists, developmental biologists
