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| MURINE HOMEOBOX GENE CONTROL OF EMBRYONIC PATTERNING AND ORGANOGENESIS, 13
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Edited By
T. Lufkin, Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY, USA
Description
The first homeobox gene was molecular cloned nearly two decades ago, and since that time tremendous progress has been made in our understanding
of the distribution of homeobox genes in the genomes of many animal species and the common functional role the encoded homeodomains play
in cell-type specification, morphogenesis and development.
The amino acid sequence of the homeodomain, as well as the presence of
other conserved protein domains, has allowed the classification of homeodomain-containing proteins (homeoproteins) into over thirty separate
families (e.g. Hox, Dlx, Msx, Otx, Hmx, Cdx etc.). In many cases a single gene has been shown to fully direct the morphogenesis
and development of a complex tissue, organ or even an entire body segment. Yet how this "master" regulatory ability of homeoproteins
functions at the molecular level to a large degree still remains a mystery, in part owing to our limited understanding of the nature
of both homeoprotein transcriptional cofactors and even more elusively, the downstream targets of homeoprotein function.
In the
reviews presented here it is limited primarily to what has been learned in vertebrate systems, principally focusing on the mouse, owing
to the strengths of the technical approaches currently existing in murine developmental genetics that are not yet available to the same
degree in other vertebrate species. Despite this mammalian predilection, a common thread to each of these reviews is the underlying importance
of what has been learned about homeoprotein function in other animal species, particularly arthropods like Drosophila.
Contents
Hox proteins and their cofactors in transcriptional regulation (M. Featherstone). Cdx homeobox proteins in vertebral patterning
(M. Houle,
D. Allan, D. Lohnes). Msx genes in organogenesis and human disease (R.E. Maxson, M. Ishii, A. Merrill). Prx, Alx, and Shox genes in craniofacial
and appendicular development
(F. Meijlink, S. Kuijper et al.). Role of Otx transcription factors in brain development (A. Simeone,
J.P. Martinez Barbera et al.). Hox gene control of neural crest cell, pharyngeal arch and craniofacial patterning (A. Iulianella,
P.A. Trainor).
| Bibliographic details |
Hardbound, 278 pages, publication date: DEC-2003
ISBN-13: 978-0-444-51498-1
ISBN-10: 0-444-51498-8
Imprint: ELSEVIER
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| Price and Ordering |
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EUR 175
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Last update: 4 Sep 2009
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