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By David Nicholls, Buck Institute, Novato, California, U.S.A. Stuart Ferguson, University of Oxford, U.K.
Description This new edition of Bioenergetics presents a clear and up-to-date explanation of the chemiosmotic theory and covers mitochondria,
bacteria, and chloroplasts. It takes account of the many newly determined structures, such as ATP synthase and the two photosystems of
photosynthesis, that provide molecular insight into chemiosmotic energy transduction. This edition includes additional color figures
of protein structures and many newly drawn illustrations designed to enable the reader to grasp the fundamental insights that are derived
from knowing the structure. Every chapter has been extensively revised and updated and a new chapter on the study of the bioenergetics
of mitochondria in the intact cell is included to satisfy the enormous interest in this topic. Written for students and researchers alike,
this book is the most current text on the chemiosmotic theory and membrane bioenergetics available.
Audience
Undergraduates, graduates, postgraduates, and researchers working in biochemistry and the biological sciences.
Contents Preface
Note to the Reader
Glossary
CHEMIOSMOTIC ENERGY TRANSDUCTION
Introduction
The Chemiosmotic Theory: Fundamentals
The Basic Morphology of Energy-Transducing Membranes
Overview
ION TRANSPORT ACROSS ENERGY-CONSERVING MEMBRANES
Introduction
The Classification of Ion Transport
Bilayer-Mediated Transport
Protein-Catalyzed Transport
Swelling and the Co-ordinate Movement of Ions
Across Membranes
QUANTITATIVE BIOENERGETICS: THE MEASUREMENT OF DRIVING FORCES
Introduction
Gibbs Energy and Displacement
from Equilibrium
Oxidation-Reduction (Redox) Potentials
Ion Electrochemical Potential Differences
Photons
Bioenergetic Interconversions
and Thermodynamic Constraints on their Stoichiometries
The Equilibrium Distributions of Ions, Weak Acids and Weak Bases
Membrane Potentials,
Diffusion Potentials, Donnan Potentials and Surface Potentials
THE CHEMIOSMOTIC PROTON CIRCUIT
Introduction
The Measurement
of Protonmotive Force
The Stoicheiometry of Proton Extrusion by the Respiratory Chain
The Stoicheiometry of Proton Uptake by the ATP
Synthase
Proton Current and Respiratory Control
Proton Conductance
Mitochondrial Respiration Rate and Metabolic Control Analysis
Overall
Parameters of Energy-Transduction
Reversed Electron Transfer and the Proton Circuit Driven by ATP Hydrolysis
ATP Synthesis Driven by
an Artificial Protonmotive Force
Kinetic Competence of p in the Proton Circuit
Light-dependent ATP Synthesis by Bovine Heart
ATP Synthase
RESPIRATORY CHAINS
Introduction
Components of the Mitochondrial Respiratory Chain
The Sequence of Redox
Carriers in the Respiratory Chain
The Mechanism of Electron Transfer
Proton Translocation by the Respiratory Chain; "loops" or "conformational
pumps" or both?
Complex I (NADH-UQ Oxidoreductase)
Delivering Electrons to Ubiquinone without Proton Translocation
Ubiquinone and Complex
III (bc1 or UQ-Cyt c Oxidoreductase)
Cytochrome c and Complex IV (Cytochrome c Oxidase; Ferrocytochrome c;
O2 Oxidoreductase)
Overall Proton and Charge Movements Catalysed by the Respiratory Chain: Correlation with the P/O Ratio
Superoxide
Production by Complex I and III
Oxidative Stress
The Nicotinamide Nucleotide Transhydrogenase
Electron Transport in Mitochondria of Non-Mammalian
Cells
Bacterial Resporatory Chains
PHOTOSYNTHETIC GENERATORS OF PROTONMOTIVE FORCE
Introduction
The Light Reaction
of Photosynthesis in Rhodobacter sphaeroides and Related Organisms
The Generation by Illumination or Respiration of p in Photosynthetic
Bacteria
The Electron-Transfer and Light-Capture Pathway in Green Plants and Algae
Bacteriorhodpsin and Halorhodopsin
THE ATP
SYNTHASE
Introduction
F1 and F0
The Subunits of the F1F0-ATPase
The Structure of F0 F1
Enzymology of ATP Synthase
Relating the
Structure to Function for ATP Synthase
Non-Thermodynamic Regulation of the ATP Synthase
Proton Translocation by Other ATPases and Pyrophosphatases
METABOLITE AND ION TRANSPORT
Introduction
Mitochondrial Cation Transporters
Mitochondrial Metabolite Transporters
The
Transfer of Electrons from Cytoplasmic NADH to the Respiratory Chai
The Phosphate and Adenine Nucleotide Transporters
The Uncoupling
Protein Family
Bacterial Transport
Transport (Movement) of Bacterial Cells
Transport of Macromolecules Across Membranes
MITOCHONDRIA
IN THE CELL
Introduction
Monitoring m and ATP Synthesis in Intact Cells
Mitochondria and Cellular Ca2+ Homeostasis
Mitochondria and Programmed Cell Death
Mitochondria and Necrotic Cell Death
The Mitochondrial Genome
Import and Assembly of Mitochondrial
Proteins
Mitochondrial Genetic Diseases
Mitochondrial Involvement in Neurodegenerative Diseases
References
Appendix
Index
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