Edited by
D.R. Welch, The Jake Gitlin Cancer Research Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033-0850 USA
By
D. Rusciano, Friedrich Miescher Institute, Maulbeerstrasse 66, Basel, CH 4058 Switzerland
M.M. Burger, Friedrich Miescher Institute, Maulbeerstrasse 66, Basel, CH-4058 Switzerland
Description
The book describes most of the methods that are currently used in metastasis research. Both
in vivo and
in vitro protocols
are illustrated, so that the metastatic process can be either analysed as a whole, or single events addressed separately. Each method
is described in the frame of the metastatic process, therefore its significance and its limitations in the context of metastasis are
always taken into account. Whenever possible, several alternative procedures are reported per each experimental issue, so that the researcher
can choose the one that better suits her/his needs and possibilities.
During the past 30 years a big effort has been made to elucidate
the molecular mechanisms of cancer metastatis, the leading cause of death for cancer patients. A considerable number of assays have been
set up, that can be used to address specific questions concerning the single metastatic steps, or can be applied to develop and test
drugs specifically interfering with selected events during the metastatic spread. This book contains an exhaustive description of most
of the methods and their rationale, that are currently used in metastatic research, both to analyse metastasis in its entirety (in vivo
models), or to dissect the single steps of the metastatic process (in vitro assays).
Included in series
Laboratory Techniques in Biochemistry and Molecular Biology
