Edited by
A. Björklund, Department of Physiological Sciences, Wallenberg Neuroscience Center, Biomedical Center A11, S-22184 Lund, Sweden
T. Hökfelt, Department of Neuroscience, Retzius Laboratory B3:4, Karolinska Institutet, Retzius väg 8, S-17177 Stockholm, Sweden
P. Quinton, IRISA/INRIAA, Rennes, France
Description
During the last few years, the pace of research in the field of neuropeptide receptors has increased steadily: new neuropeptides were
discovered, and the classification of receptor subtypes has been refined. It thus appeared essential to update the information.
Peptide
Receptors Part I summarizes current knowledge on ten distinct peptide families.
This volume integrates photomontages and maps
of quantitative receptor autoradiography,
in situ hybridization histochemistry, and immunocytochemistry images. Application
of these classical techniques and of new approaches such as transgenic and knock-out animals has revealed a distinct species and tissue
specific variation in receptor subtypes expression and pharmacology in the mammalian central nervous system.
The functional role
of neuropeptides and their receptors in the CNS has been investigated thanks to the development of potent and selective receptor antagonists
and agonists. The development of specific neuropeptide-related molecules will help to get a better understanding of receptor subtype
physiology and neuronal distribution and may lead to innovative treatments in a variety of brain disorders.
Included in series
Handbook of Chemical Neuroanatomy
