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From Laboratory to Clinic
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Edited By
Craig Halberstadt, Carolinas Medical Center, Charlotte, North Carolina
Dwaine Emerich, LCT Biopharma, Providence, Rhode Island, U.S.A.
Description
There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain
diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism
or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy.
Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting
field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into
the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among
the hurdles representing the next frontier.
The contents are organized into four main sections, with the first covering basic biology,
including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation.
The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the
central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable
cells and integrating biomaterials and nanotechnology with cell matrices.
Audience
Researchers and clinicians in the field of cell transplantation, as well as students in cell biology interested in how the field relates to cell transplantation.
Contents
A. BASIC BIOLOGY OF CELL THERAPY.
1. Immunology of Cell and Tissue Transplantation.
2. Current Immunosuppressive Drugs and Clinical Use.
3. Stem and Precursor Cells for Transplant Therapy.
4. Creating Animals for Cell Xenotransplantation.
B. CELL THERAPY FOR PERIPHERAL
DISEASES AND RECONSTRUCTIVE APPLICATIONS.
5. Islet Transplants for Diabetes: The Edmonton Protocol.
6.
7. Encapsulated Human Islet Allografts:
Providing Safety with Efficacy.
8. Strategies for Cell Replacement for Kidney Failure.
9. Strategies for Extracorporeal Devices for
Kidney Failure.
10. Transplants for Hemophilia.
11. Cell Therapy for Peripheral Diseases and Reconstructive Applications: Transplants
for Lysosomal Storage Disease.
12. Cellular Transplants for Liver Diseases.
13. Stem Cell Transplantation for Autoimmune Diseases.
14.
Cardiac Cell Transplantation.
15. Engineered Cylindrical Cartilage Transplantation as Tracheal Replacements.
16. Muscle Cell Transplants.
C. CELL THERAPY FOR CNS DISEASES.
17. Immunological Consideration in CNS Transplants.
18. Neurotrophic Cell Transplants for Degenerative
Diseases of the Eye.
19. Transplants for Glioblastoma.
20. NT2N Cell Transplantation and GDNF Treatment in Stroke: Linking Neurotrophic
Factor Therapy and Neuroprotection.
21. NGF Producing Cell Transplants for Alzheimer?s Disease.
22. Transplants of CNTF-Producing Cells
for the Treatment of Huntington?s Disease.
23. Choroid Plexus Epithelial Cell Transplants for Repair of the Brain.
24. Neural Transplantation
in Huntington?s Disease.
25. Neural Transplantation in Parkinson?s Disease.
26. Transplants for Chronic Pain.
27. Cell Grafting for Spinal
Cord Injury Repair: Cell Replacement and Bridging Strategies.
28. Human Embryonic Stem Cells, Dopaminergic Neurons, and Pathways for
Developing a Parkinson's Disease Therapy.
D. FUTURE AVENUES OF CELL THERAPY.
29. Concepts in Cell Therapy: From Cord Blood to Sertoli
Cells.
30. Immunologically Privileged Environments.
31. Converging Cell Therapy with Biomaterials.
32. Nanotechnology?s Impact on Cell
Transplantation.
33. Design and Implementation of a Cell Processing Facility.
34. Developing Cell Therapy Products.
| Bibliographic details |
Hardbound, 696 pages, publication date: DEC-2006
ISBN-13: 978-0-12-369415-7
ISBN-10: 0-12-369415-9
Imprint: ACADEMIC PRESS
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USD 199.95
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Last update: 5 Sep 2009
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