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ORIGIN AND EVOLUTION OF VIRUSES
Origin and Evolution of Viruses

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Edited By
Esteban Domingo, Centro de Biologia Molecular Severo Ochoa, Madrid, Spain
Robert Webster, St. Jude Children's Research Hospital, Memphis, Tennessee, U.S.A.
John Holland, University of California, San Diego, U.S.A.

Description
Are infectious diseases caused by novel entities, viruses that have rapidly evolved into more pathogenic forms, or viruses that have crossed species divides and become more virulent in their alternative host? These questions and how new diseases such as AIDS emerged have prompted renewed interest in the ways viruses originated and co-evolved with their hosts.Origin and Evolution of Viruses presents a full and clear description of general viral concepts and specific viral systems, and provides an excellent foundation to our understanding of how viruses emerged. This unique and comprehensive work is essential reading for all researchers in virology, molecular biology and related areas, as well as evolutionary biologists interested in phylogenetic approaches to molecular evolution. The reader is taken on an illumination journey--in time and concepts--from the first primitive replicons to their present-day complex viral counterparts. Apart from the obvious interest, as humans are potential hosts for these viruses, there is also a great deal of academic interest in the evolutionary aspects of this simple group of organisms, since information can be gained about the origin of stains/species and evolutionary patterns that might be applicable to higher species.

Audience
Researchers in virology, molecular biology, and evolutionary biology interested in phylogenetic approaches to molecular evolution.

Contents
P. Schuster and P.F. Stadler, Nature and Evolution of Early Replicons.H.D. Robertson and O.D. Neel, Virus Origins: Conjoined RNA Genomes as Precursors to DNA Genomes.J.S. Semancik and N. Duran-Vila, Viroids in Plants: Shadows and Footprints of a Primitive RNA.C. Biebricher, Mutation, Competition, and Selection as Measured with Small RNA Molecules.A. Meyerhans and J.-P. Vartanian, The Fidelity of Cellular and Viral Polymerases and Its Manipulation for Hypermutagenesis.S. Wain-Hobson and M. Sala, Drift and Conservatism in RNA Virus Evolution: Are They Adapting or Merely Changing?E. Domingo, C. Escarmís, L. Menéndez-Aarias, and J.J. Holland, Viral Quasispecies and Fitness Variations.M.A. McClure, The Retroid Agents: Disease, Function, and Evolution.D. Wodarz and M.A. Nowak, Dynamics of HIV Pathogenesis and Treatment.I.M. Rouzine and J.M. Coffin, Interplay between Experiment and Theory in Development of a Working Model for HIV-1 Population Dynamics.A.J. Gibbs, P.L. Keese, M.J. Gibbs, and F. García-Arenal, Plant Virus Evolution: Past, Present, and Future.M. Gromeier, E. Wimmer, and A.E. Gorbalenya, Genetics, Pathogenesis, and Evolution of Picornaviruses.J.I. Esteban, M. Martell, W.F. Carman, and J. Gómez, The Impact of Rapid Evolution of the Hepatitis Viruses.R.G. Webster, Antigenic Variation in Influenza Viruses. L.P. Villarreal, DNA Virus Contribution to Host Evolution.C.R. Parrish and U. Truyen, Parvovirus Variation and Evolution. D.J. McGeoch and A.J. Davison, The Molecular Evolutionary History of the Herpesviruses.J. Salas, M.L. Salas, and E. Vi uela, African Swine Fever Virus: A Missing Link Between Poxviruses and Iridoviruses? Subject Index.

Bibliographic details
Hardbound, 500 pages, publication date: JUN-1999
ISBN-13: 978-0-12-220360-2
ISBN-10: 0-12-220360-7
Imprint: ACADEMIC PRESS

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USD 220
GBP 132.99
EUR 156.95
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Last update: 30 Nov 2009
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