By
Barry Bunin, Arris Pharmaceutical, South San Francisco, CA
Description
With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic
chemist who is contemplating a combinatorial approach to a medicinal chemistry problem.
The Combinatorial Index is an
answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic
transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points
of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis
for the generation of molecular diversity.
Audience:
Organic and medicinal chemists in the pharmaceutical and agrochemical industries and academia as well as their institutional libraries.
