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THE COMBINATORIAL INDEX
The Combinatorial Index

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By
Barry Bunin, Arris Pharmaceutical, South San Francisco, CA

Description
With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity.

Audience
Organic and medicinal chemists in the pharmaceutical and agrochemical industries and academia as well as their institutional libraries.

Contents
Introduction. Background. Linkers for Solid-Phase Synthesis. Combinatorial Solid-Phase Synthesis. Analytical Methods for Solid-Phase Synthesis. The Preparation of Solution Libraries and Combined Approaches at the Solution/Solid-Phase Interface. Appendix 1: Summary of Functional Group Transformations for Combinatorial Solid-Phase Synthesis. Appendix 2: Classification of Heterocyclization Reactions. Appendix 3: Unnatural Biopolymers. Appendix 4: Oligosaccharides. Appendix 5:List of Abbreviations. Index.

Bibliographic details
Hardbound, 322 pages, publication date: FEB-1998
ISBN-13: 978-0-12-141340-8
ISBN-10: 0-12-141340-3
Imprint: ACADEMIC PRESS

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EUR 95.95
GBP 81
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Last update: 7 Sep 2009
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