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| PHAGOCYTOSIS: THE HOST, 5
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Edited By
S. Gordon, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
Included in series
Advances in Cellular and Molecular Biology of Membranes and Organelles, 5
Description
An accompanying volume (Volume 6) in this series presents strategies of cellular invasion from the viewpoint of the microbe.
This
filed of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect
current research, and brings together cell biologists, microbiologists and immunologists with disparate interests. However, there is
a certain unity, even repetition of key themes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial
bias favors intracellular paratism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage,
and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively
early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host
cell or pathogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although
it is cytogenes, share common strategies in invasion and intercellular spread.
Contents
Contents. List of Contributors. Introduction to the Series. Preface (S. Gordon). Secton I Context. The early History of Phagocytosis (T.P.
Stossel). Drosophila Hemocytes, Phagocytosis, and Croquemort, a Macrophage Receptor (N.C. Franc). Phagocytosis by Nonprofessional Phagocytes
(D. Williams-Herman and Z. Werb). Section II Receptors. Scavenger Receptors and Phagocytosis of Bacteria and Apoptotic Cells (N. Platt,
R. Haworth, R.P. da Silva, and S. Gordon). Mannose Receptor and Phagocytosis (I.P. Fraser, R. Alan and B. Ezekowitz). Integrin Receptors
of Phagocytes (S.D. Blystone and E.J. Brown). Fc Receptor-Mediated Phagocytosis (S. Greenberg). Section III Signaling. Heterogeneity
in Macrophage Phagocytosis (A. Aderem and D.M. Underhill). Signaling through RHO GTPases in Phagocytes (A.E. Abo). Regulatory Roles of
Phosphatidylinositol (4,5) Bisphosphate in Cell Signalin, Membrane Traffic, and the Cytoskeleton (S. Cockcroft). Section IV The Pathway.
Pathways through the Macrophage Vacuolar Compartment (J.A. Swanson). Sequential Maturation of Phagosomes provides unique Targets for
Pathogens (C. Alvarez-Dominguez, L. Mayorga, and P.D. Stahl). Phagosomal Acidification: Mechanisms and Funtional Significance (D.J. Hackam,
O.
D. Rotstein, and S. Grinstein). The Phagocyte Actin Cytoskeleton (H. Sun, K. Lin, M. Yamamoto, and H.L. Yin). Section V Responses.
Nramp1: A Novel Macrophage Protein with a Key Function in Resistance to Intracellular Pathogens (S. Gruenheid, E. Skamene, and P. Gros).
Uptake and Presentation of Phagocytosed Antigens by Dendritic Cells (M.L. Albert, S. Turley, W. Garrett, I. Mellman, K. Inaba, N. Bhardway,
and R.M. Steinman). Processing and Presentation of Phagocytosed Antigens to the Immune System (J. Pieters). Antimicrobial Mechanisms
of Macrophages (M.U. Shiloh and C.F. Nathan). Components and Organization of the Nadph Oxidase of Phagocytic Cells: Its Role in Microbial
Killing and in the Molecular Pathology of Chronic Granulomatous Disease (A.W. Segal, f. wientjes, R.W. Stockley, and L.V. Dekker). Oxygen-Independent
Antimicrobial Mechanisms of PMN (P. Elsbach). Index.
| Bibliographic details |
Hardbound, 0 pages, publication date: NOV-1999
ISBN-13: 978-1-55938-999-0
ISBN-10: 1-55938-999-0
Imprint: ELSEVIER
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