MANDELL, DOUGLAS, AND BENNETT'S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES
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By John Bennett, MD, Potomac, MD, USA Raphael Dolin, MD, Maxwell Finland Professor of Medicine, Microbiology and Molecular Genetics, Dean for Academic and Clinical Programs Harvard Medical School Boston, MA, USA
Description
After thirty years, PPID is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging
infectious diseases. Drs. Mandell, Bennett, and Dolin have substantially revised and meticulously updated, this new edition to save you
time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated
coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett's Principles and Practice of Infectious
Diseases, 7th Edition helps you identify and treat whatever infectious disease you see. And, as an Expert Consult title with enhanced
online features, this updated 7th edition comes with convenient access to the full text online, regular updates on the new developments
in the field and advances in therapy, and more at expertconsult.com.
Audience
Infectious Disease
Contents
Part I Basic Principles in the Diagnosis and Management of Infectious Diseases
Section A. Microbial Pathogenesis
1
A Molecular Perspective of Microbial Pathogenicity 2 Microbial Adherence 3 Toxins
Section B. Host Defense Mechanisms
4
Innate (General or Nonspecific) Host Defense Mechanisms 5 Human Genetics and Infection 6 Antibodies 7 Complement 8 Granulocytic
Phagocytes 9 Cell-Mediated Defense Against Infection 10 Nutrition, Immunity, and Infection 11 Probiotics 12 Evaluation of
the Patient with Suspected Immunodeficiency
Section C. Epidemiology of Infectious Diseases
13 Epidemiologic
Principles 14 Outbreak Investigation 15 Emerging and Reemerging Infectious Disease Threats 16 Hospital Preparedness for Emerging
and Highly Contagious Infectious Diseases
Section D. Clinical Microbiology
17 The Clinician and the Microbiology
Laboratory
Section E. Anti-Infective Therapy
18 Principles of Anti-infective Therapy 19 Molecular Mechanisms
of Antibiotic Resistance in Bacteria 20 Pharmacokinetics and Pharmacodynamics of Anti-infective Agents 21 Penicillins 22 Cephalosporins 23
Other a-Lactam Antibiotics 24 a-Lactam Allergy 25 Fusidic Acid 26 Aminoglycosides 27 Tetracyclines and Chloramphenicol 28
Rifamycins 29 Metronidazole 30 Macrolides, Clindamycin, and Ketolides 31 Glycopeptides, Streptogramins, and Lipopeptides 32
Polymyxins (Polymyxin B and Colistin) 33 Oxazolidinones 34 Sulfonamides and Trimethoprim 35 Quinolones 36 Unique Antibacterial
Agents 37 Urinary Tract Agents: Nitrofurantoin and Methenamine 38 Topical Antibacterials 39 Antimycobacterial Agents 40 Antifungal
Agents 41 Antiviral Drugs (Other Than Antiretrovirals) 42 Immunomodulators 43 Hyperbaric Oxygen 44 Agents Active against
Parasites and Pneumocystis 45 Complementary and Alternative Medicines for Infectious Diseases 46 Antimicrobial Management: Cost
and Resistance 47 Interpretation of Clinical Trials of Antimicrobial Agents 48 Outpatient Parenteral Antimicrobial Therapy 49
Tables of Antimicrobial Agent Pharmacology
Part II Major Clinical Syndromes
Section A. Fever
50
Temperature Regulation and the Pathogenesis of Fever 51 Fever of Unknown Origin 52 The Acutely Ill Patient with Fever and Rash
Section
B. Upper Respiratory Tract Infections
53 The Common Cold 54 Pharyngitis 55 Actue Laryngitis 56 Acute Laryngotracheobronchitis
(Croup) 57 Otitis Externa, Otitis Media, and Mastoiditis 58 Sinusitis 59 Epiglottitis 60 Infections of the Oral Cavity, Neck,
and Head
Section C. Pleuropulmonary and Bronchial Infections
71
Peritonitis and Intraperitoneal Abscesses 72 Infections of the Liver and Biliary System 73 Pancreatic Infections 74 Splenic
Abscess 75 Appendicitis 76 Diverticulitis and Typhlitis
Section G. Cardiovascular Infections
77
Endocarditis and Intravascular Infections 78 Prosthetic Valve Endocarditis 79 Infections of Non-Valvular Cardiovascular Devices 80
Prophylaxis of Infective Endocarditis 81 Myocarditis and Pericarditis 82 Mediastinitis
Section H. Central Nervous
System Infections
83 Approach to the Patient with Central Nervous System Infection 84 Acute Meningitis 85 Infections
of CSF Shunts 86 Chronic Meningitis 87 Encephalitis, Myelitis, and Neuritis 88 Brain Abscess 89 Subdural Empyema, Epidural
Abscess, and Intracranial Suppurative Thrombophlebitis
Section I. Skin and Soft Tissue Infections
90 Cellulitis,
Necrotizing Fasciitis and Subcutaneous Tissue Infections 91 Myositis 92 Lymphadenitis and Lymphangitis
Section J.
Gastrointestinal Infections and Food Poisoning
93 Principles and Syndromes of Enteric Infection 94 Esophagitis 95
Nausea, Vomiting, and Noninflammatory Diarrhea 96 Antibiotic-Associated Colitis 97 Inflammatory Enteritides 98 Enteric Fever
and Other Causes of Abdominal Symptoms with Fever 99 Foodborne Disease 100 Tropical Sprue/Enteropathy 101 Whipple's Disease
Section
K. Bone and Joint Infections
102 Infectious Arthritis 103 Osteomyelitis 104 Infections in Prostheses in Bones and
Joints
Secction L. Diseases of the Reproductive Organs and Sexually Transmitted Diseases
105 Genital Skin
and Mucous Membrane Lesions 106 Urethritis 107 Vulvovaginitis and Cervicitis 108 Infections of the Female Pelvis 109 Prostatitis,
Epididymitis, and Orchitis
117 Global
Perspectives on HIV Infection and Acquired Immunodeficiency Syndrome 118 Epidemiology and Prevention of AIDS and HIV Infection 119
Diagnosis of Human Immunodeficiency Virus Infection 120 The Immunology of Human Immunodeficiency Virus Infection 121 General Clinical
Manifestations of Human Immunodeficiency Virus Infection 122 Pulmonary Manifestations of Human Immunodeficiency Virus Infection 123
GI and Hepatobiliary Manifestations of Human Immunodeficiency Virus Infection 124 Neurologic Diseases Caused by HIV-1 and Opportunistic
Infections 125 Malignancies in Human Immunodeficiency Virus Infection 126 Human Immunodeficiency Virus Infection in Women 127
Pediatric Human Immunodeficiency Virus Infection 128 Antiretroviral Therapy for Human Immunodeficiency Virus Infection 129 Management
of Opportunistic Infections Associated with HIV Infection 130 Vaccines for Human Immunodeficiency Virus-1 Infection
Section
P. Miscellaneous Syndromes
131 Chronic Fatigue Syndrome
Part III Infectious Diseases and Their Etiologic
Agents
Section A. Viral Diseases
132 Introduction to Viruses and Viral Diseases - DNA Viruses - Poxviridae 133
Orthopoxviruses: Vaccinia, Variola, Monkeypox, and Cowpox 134 Other Poxviruses: Parapoxviruses, Molluscum Contagiosum, and Tanapox
Herpesviridae 135 Introduction to Herpesviridae 136 Herpes Simplex Virus 137 Varicella-Zoster Virus 138 Cytomegalovirus 139
Epstein-Barr Virus (Infectious Mononucleosis) 140 Human Herpesvirus Types 6 and 7 141 Kaposi's Sarcoma-Associated Herpesvirus (Human
Herpesvirus Type 8) 142 Herpes B Virus - Adenoviridae 143 Adenovirus - Papovaviridae 144 Papillomaviruses 145 JC, BK, and
Other Polyomaviruses; Progressive Multifocal Leukoencephalopathy - Hepadnaviridae 146 Hepatitis B Virus and Hepatitis Delta Virus
- Parvoviridae 147 Human Parvoviruses - RNA Viruses - Reoviridae 148 Orthoreoviruses and Orbiviruses 149 Coltiviruses and Seadornaviruses
(Colorado Tick Fever) 150 Rotaviruses - Togaviridae 151 Alphaviruses 152 Rubella Virus (German Measles) - Flaviviruses 153
Flaviviruses (Yellow Fever, Dengue, Dengue Hemorrhagic Fever, Japanese Encephalitis, West Nile Encephalitis, St. Louis Encephalitis,
Tick-Borne Encephalitis) 154 Hepatitis C - Coronaviridae 155 Coronaviruses, Including SARS-Associated Coronavirus Paramyxoviridae 156
Parainfluenza Viruses 157 Mumps Virus 158 Respiratory Syncytial Virus 159 Human Metapneumovirus 160 Measles Virus (Rubeola) 161
Zoonotic Paramyxoviruses: Hendra, Nipah, and Menangle Viruses Rhabdoviridae 162 Vesicular Stomatitis Virus and Related Viruses 163
Rhabdoviruses - Filoviridae 164 Marburg and Ebola Virus Hemorrhagic Fevers - Orthomyxoviridae 165 Influenza Viruses Including Avian
Influenza - Bunyaviridae 166 California Encephalitis, Hantavirus Pulmonary Syndrome, and Bunyavirid Hemorrhagic Fevers - Arenaviridae 167
Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers - Retroviridae 168 Human T-Cell Lymphotropic
Virus Types I and II 169 Human Immunodeficiency Viruses - Picornaviridae 170 Introduction to the Enteroviruses 171 Poliovirus 172
Coxsackieviruses, Echoviruses, and Newer Enteroviruses 173 Hepatitis A Virus - Caliciviridae and Other Gastrointestinal Viruses 174
Rhinovirus 175 Noroviruses and Other Caliciviruses 176 Astroviruses and Picobirnaviruses - Unclassified Viruses 177 Hepatitis
E Virus
Section B. Prion Diseases
178 Prions and Prion Diseases of the Central Nervous System (Transmissible
Neurodegenerative Diseases)
Section C. Chlamydial Diseases
179 Introduction to Chlamydial Diseases 180
Chlamydia trachomatis (Trachoma, Perinatal Infections, Lymphogranuloma Venereum, and Other Genital Infections) 181 Chlamydophila (Chlamydia)
psittaci (Psittacosis) 182 Chlamydophila (Chlamydia) pneumoniae 183 Introduction to Mycoplasma Diseases 184 Mycoplasma pneumoniae
and Atypical Pneumonia
Section D. Mycoplasma Diseases
185 Genital Mycoplasmas: Mycoplasma genitalium,
Mycoplasma hominis, and Ureaplasma Species
Section E. Rickettsioses, Ehrlichioses, and Anaplasmosis
186
Introduction to Rickettsioses, Ehrlichioses and Anaplasmosis 187 Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky
Mountain Spotted Fever and Other Spotted Fevers) 188 Rickettsia akari (Rickettsialpox) 189 Coxiella burnetii (Q Fever) 190 Rickettsia
prowazekii (Epidemic or Louse-Borne Typhus) 191 Rickettsia typhi (Murine Typhus) 192 Orientia Tsutsugamushi 193 Ehrlichia Chaffeensis
and Ehrlichia Phagocytophila
Section F. Bacterial Diseases
194 Introduction to Bacteria and Bacterial
Diseases - Gram-Positive Cocci 195 Staphylococcus aureus (Including Staphylococcal Toxic Shock) 196 Staphylococcus epidermidis
and Other Coagulase-Negative Staphylococci 197 Classification of Streptococci 198 Streptococcus pyogenes 199 Nonsuppurative
Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis 200 Streptococcus pneumoniae 201 Enterococcus Species, Streptococcus
bovis, and Leuconostoc Species 202 Streptococcus agalactiae (Group B Streptococcus) 203 Viridans Streptococci, Groups C and G Streptococci,
and Gemella morbillorum 204 Streptococcus anginosus Group - Gram-Positive Bacilli 205 Corynebacterium diphtheriae 206 Corynebacteria
other than Diphtheria and Rhodococcus 207 Listeria monocytogenes 208 Bacillus anthracis (Anthrax) 209 Bacillus Species and Other
than Bacillus anthracis 210 Erysipelothrix rhusiopathiae - Gram-Negative Cocci 211 Neisseria meningitidis 212 Neisseria gonorrhoeae 213
Moraxella catarrhalis and Other Gram-Negative Cocci - Gram-Negative Bacilli 214 Vibrio cholerae 215 Other Pathogenic Vibrios 216
Campylobacter jejuni and Related Species 217 Helicobacter pylori and Other Gastric Helicobacter Species 218 Enterobacteriaceae 219
Pseudomonas species, including Ps. aeruginosa 220 Stenotrophomonas maltophilia and Burkholderia cepacia complex 221 Burkholderia
pseudomallei and Burkholderia mallei 222 Acinetobacter Species 223 Salmonella Species, Including Salmonella typhi 224 Shigella
Species (Bacillary Dysentery) 225 Haemophilus species (incluing H. influenzae and chancroid) 226 Brucella Species 227 Francisella
tularensis (Tularemia) 228 Pasteurella Species 229 Yersinia Species, Including Plague 230 Bordetella Pertussis 231 Rat-Bite
Fever Streptobacillus moniliformis and Spirillum minus 232 Legionella 233 Other Legionella Species 234 Capnocytophaga 235
Bartonella, Including Cat-Scratch Disease 236 Calymmatobacterium granulomatis (Donovanosis, Granuloma Inguinale) 237 Other Gram-Negative
and Gram-Variable Bacilli - Spirochetes 238 Treponema pallidum (Syphilis) 239 Endemic Treponematoses 240 Leptospira Species
(leptospirosis) 241 Borrelia Species (Relapsing Fever) 242 Borrelia burgdorferi (Lyme Disease, Lyme Borreliosis) - Anaerobic Bacteria 243
Anaerobic Infections: General Concepts 244 Clostridium tetani (Tetanus) 245 Clostridium botulinum (Botulism) 246 Gas Gangrene
and Other Clostridium-Associated Diseases 247 Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species 248 Anaerobic Cocci;
Anaerobic 249 Anaerobic Gram-Positive Non-sporulating Bacilli - Mycobacterial Diseases 250 Mycobacterium tuberculosis 251 Mycobacterium
leprae 252 Mycobacterium Avium-intracellulare 253 Infections due to Mycobacteria other than M. tuberculosis and M. Avium Complex
-Higher Bacterial Diseases 254 Nocardia Species 255 Agents of Actinomycosis
Section G. Mycoses
256
Introduction to Mycoses 257 Candida Species 258 Aspergillus Species 259 Agents of Mucormycosis 260 Sporothrix schenckii 261
Agents of Chromomycosis 262 Agents of Mycetoma 263 Cryptococcus neoformans 264 Histoplasma capsulatum 265 Blastomyces dermatitidis 266
Coccidioides Species 267 Dermatophytosis and Other Superficial Mycoses 268 Paracoccidioides brasiliensis 269 Uncommon Fungi
and Prototheca 270 Pneumocystis 271 Microsporidiosis
Section H. Protozoal Diseases
272 Introduction
to Protozoal Diseases 273 Entamoeba species including amoebiasis 274 Free-Living Amebas 275 Plasmodium Species (Malaria) 276
Leishmania Species: Visceral, Cutaneous, and Mucocutaneous Leishmaniasis 277 Biology of Trypanosoma Species 278 Agents of African
Trypanosomiasis (Sleeping Sickness) 279 Toxoplasma gondii 280 Giardia lamblia 281 Trichomonas vaginalis 282 Babesia Species 283
Cryptosporidium Species 284 Isospora belli, Sarcocystis Species, Blastocystis hominis and Cyclospora
Section I. Diseases
Due to Toxic Algae
285 Human Illness Associated with Harmful Algal Blooms
Section J. Diseases Due to Helminths
286
Introduction to Helminth Infections 287 Intestinal Nematodes (Roundworms) 288 Tissue Nematodes, Including Trichinosis, Dracunculiasis,
and the Filariases 289 Trematodes (Schistosomes and Other Flukes) 290 Cestodes (Tapeworms) 291 Visceral Larva Migrans and Other
Unusual Helminth Infections
299 Organization for Infection Control 300 Isolation 301 Disinfection, Sterilization, and Control of
Hospital Waste 302 Infections Caused by Percutaneous Intravascular Devices 303 Nosocomial Pneumonia 304 Nosocomial Urinary Tract
Infections 305 Nosocomial Hepatitis and Other Infections Transmitted by Blood and Blood Products 306 Human Immunodeficiency Virus
in Health Care Settings 307 Nosocomial Herpesvirus Infections
Section B. Infections in Special Hosts
308
Infections in the Immunocompromised Host: General Principles 309 Prophylaxis and Empirical Therapy of Infection in Cancer Patients 310
Risk Factors and Approaches to Infections in Transplant Recipients 311 Infections in Hematopoietic Stem Cell Transplant Recipients 312
Infections in Solid Organ Transplant Recipients 313 Infections in Patients with Spinal Cord Injury 314 Infections in the Elderly 315
Infections in Asplenic Patients 316 Infections in Injection Drug Users 317 Postoperative Infections and Antimicrobial Prophylaxis
Section C. Surgical and Trauma-Related Infections
318 Infections in Patients with Burns 319 Bites
Section
D. Immunization
320 Immunization
Section E. Biodefense
321 Bioterrorism: An Overview 322
Plague as Bioterrorism Weapon 323 Tularemia as a Bioterrorism Weapon 324 Smallpox as an Agent of Bioterrorism 325 Anthrax as
an Agent of Bioterrorism 326 Botulinum Toxin as an Agent of Bioterrorism 327 Viral Hemorrhagic Fevers as Agents of Bioterrorism
Section
F. Zoonoses
328 Zoonoses Section G. Protection of Travelers 329 Protection of Travelers 330 Infections in Returning
Travelers
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