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CRITICAL CARE TOXICOLOGY
Critical Care Toxicology
Diagnosis and Management of the Critically Poisoned Patient
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By
Jeffrey Brent, MD, PhD, Clinical Professor of Medicine, University of Colorado Health Sciences Center, Toxicology Associates, Prof LLC, Denver, CO, USA
Kevin Wallace, MD, Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, AZ, USA
Keith Burkhart, MD, FACMT, FACCT, FACEP, Professor of Emergency Medicine, Medicine, and Pharmacology, The Pennsylvania State University; Medical Director, Penn State Poison Center, Hershey, PA, USA
Scott Phillips, MD, FACP, FACMT, Associate Clinical Professor of Medicine and Surgery, Division of Clinical Pharmacology, Toxicology and Emergency Medicine, Toxicology Associates, Prof LLC, Denver, CO, USA
J. Donovan, MD, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA, USA

Description
Numerous references describe the initial treatment of the acutely poisoned patient; however, this new book is the first major critical care toxicology resource that details patient care from hospital admission and treatment all the way through stabilization, monitoring, and discharge. It presents practical, state-of-the-art treatment recommendations based on initial and subsequent presentation of symptoms, and describes when it's safe to discharge the patient.

Contents


Part I. General Management of the Critically Poisoned Patient


1. The Critically Poisoned Patient

2. The Diagnosis of Poisoning

3. Therapeutic Approach to the Critically Poisoned Patient

4. The Role of Toxicology Laboratory Management in the Acutely Poisoned Patient

5. Gastrointestinal Decontamination

6. Charcoal

7. Extracorporeal Removal of Toxic Substances

8. Medical Complications of Poisoning

9. Psychiatric Issues in the Critically Poisoned Patient

10. The Poisoned Pediatric Patient

11. Poisoning in Pregnancy

12. Geriatric Poisoning

13. The Critically Poisoned Worker

14. Complications of Chronic Alcoholism That Impact on Critical Illness

15. Poisoning Fatalities

16. The Treatment of Critically Ill Patients with Hyperbaric Oxygen Therapy



Part II. Toxic Syndromes


17. Hepatotoxic Syndromes

18. Drug-Induced Renal Failure

19. Toxin-Induced Alterations of Consciousness

20. Toxin-Induced Seizures

21. Cardiac Conduction and Rate Disturbances

22. Anticholinergic Syndrome

23. Cholinergic Syndrome

24. Serotonin Syndrome

25. Malignant Syperthermia

26. Neuroleptic Malignant Syndrome

27. Toxic Pulmonary Syndromes

28. Hematologic Syndrome Hemolysis, Methemoglobinemia and Sulfhemoglobeiemia

29. Acid-Base Disorders

30. Withdrawal Syndromes

31. Immunologic Reactions to Drugs, Biological Agents, and Chemicals
32. Sympathomimetric Syndrome



Part III. Medications


Cardiovascular

33. Digitalis Glycosides

34. B-Blockers

35. Calcium Channel Blockers

36. Sodium Channel Blocking Antidysrhythmias

37. Nitroprusside

Decongestant/Antihistaminergic/Bronchodilatory
38. Imidazoline, Guanidine and Oxazoline Antihypertensives and Decongestants

39. Antihistamines

40. Theophylline and Other Methyl Xanthines

41. Sympathomimetic Agents

Psychotropic

42. Cyclic Antidepressants

43. Monomine Oxidase Inhibitors

44. Serotoninergic Antidepressants

45. Poisoning by Neuroleptic Agents

46. Lithium

47. Anxiolytic/Sedative Hypnotics

48. Barbituates

Anticonvulsant

49. Phenytoin

50. Carbamazepine

51. Valproic Acid

Neuromuscular

52. Baclofen

53. Centrally Acting Muscle Relaxants

54. Anti-Parkinson's Medications

Analgesic/Anti-Inflammatory

55. Acetaminophen (Paracetamol)

56. Opioids

57. Salicylates

58. Nonsteroidal Anti-Inflammatory Agents

59. Gold Compounds

60. Methotrexate

Antimicrobial

61. Isoniazid

62. Rifampin, Dapsone and Vancomycin

63. Chloroquine and Quinine

64. Lactic Acidosis and Nucleoside Analogue Reserve Transcriptase Inhibitors

Hematologic

65. Iron

66. Oral Anticoagulants

67. Parenteral Anticoagulants and Thrombolytics

68. Antitubulins: Colchicine, Podophyllin, Vincristine and Vinblastin

69. Ergot Alkaloids

70. Anti-Diabetic Agents



Part IV. Drugs of Abuse


71. Gamma-Hydroxybutyrate (GHB) and Its Congeners

72. Indole Halllucinogens

73. Amphetamines and Derivatives

74. Poisoning by PCP and Congeners

75. Cocaine Poisoning



Part V. Chemical Agents


76. Arsenic

77. Cadmium

78. Lead

79. Mercury

80. Miscellaneous Metals

81. Phosphorus

82. Thallium

83. Poisoning by Ethylene Glycol and Glycol Ethers

84. Hydrocarbon and Halogenated Hydrocarbons

85. Isoproply Alcohol

86. Methanol and Formaldehyde Poisoning
Pesticides

87. Chlorophenoxy Herbicides

88. Fumigants

89. Fungicides

90. Organochlorine Insecticides and Pyrethoids

91. Organophosphorus and Carbamate Insecticide

92. Paraquat and Diquat

93. Rodenticides


Gases and Vapors

94. Carbon Monoxide

95. Cyanide Hydrogen Cyanide, Inorganic Cyanide Salts, and Nitriles

96. Isocyanates and Other Important Chemical Pulmonary Sensitizers

97. Irritant and Toxic Respiratory Injuries

98. Hydrogen Sulfide

Acids and Bases

99. Caustics

100. Hydrofluoric Acid



Part VI. Biological Toxins


101. Overview of Snake Envenoming

102. Rattlesnakes and Other Crotalids

103. North American Coral Snakes and Related Elapids

104. Envenoming by European Snakes

105. Australian and Pacific Snakes

106. Envenomation by Asian Snakes

107. Krait Snakes

108. Envenomation by African Snakes

109. Envenomation by Latin American Snakes

Arthopods

110. Overview of Spider

111. Widow and Related Latrodectus Spider Envenomation

112. Loxoscelism – Envenomation by Loxosceles Spiders

113. Funnel Web Spider Envenomation

114. Scorpion Envenomation

Marine Toxins

115. Poisoning by Marine Vertebrates, Coelenterates and Mollusks

116. Ciguatera Poisoning

117. Scombroid Poisoning

118. Tetrodotoxin Poisoning

Mushrooms

119. An Overview of Mushroom Poisoning

120. Cyclopeptide Containing Mushrooms: The Deadly Aminitas

121. Gyromitra Poisoning

Plants

122. An Overview of Plant and Herbal Toxicity

123. Water Hemlock Poisoning

124. Poison Hemlock

125. Cardiotoxic Plants

126. Anticholinergic Plants

127. Toxalbumins

Miscellaneous

128. Botulism Poisoning

129. Massive Hymenopteran Envenomation



Part VII. Agents of Chemical and Biological Terrorism


130. Chemical and Biological Terrorism Incidents and Intensive Care

Chemical Agents

131. Nerve Agent Poisoning

Biological Agents

132. Anthrax

133. Plague

134a. Smallpox

134b. Encephalitis and Hemorrhagic Fever Viruses



Part VIII. Antidotes


135. Immunotherapy of Poisonings

136. N-Acetylcysteine

137. Opioid Antagonists

138. Flumzanil

139. British Anti-Lewisite

140. Calcium Disodium EDTA

141. Succimer

142. DMPS

143. Deferoxamine

144. Atropine

145. Oximes

146. Bromocriptine

147. Pyridoxine

148. Nitrites

149. Thiosulfate

150. Cyanide Binding Anidotes: Dicobalt Edetate and Hydroxycobalamin

151. Ethanol

152. Fomepizole

153. Physostigmine

154. Anti-Digitalis Fab Fragments

155. Methylene Blue

156. Dantrolene

157. Folic and Folinic Acid

158. Thiamine

159. 4-Diamethylaminopherol (4-DMAP) as Antidote for Poisoning by Cyanide


Appendices

A. FDA Pregnancy Risk Categories

B. Doses of Sympathomimetics

C. Adjustment of Drug Doses in ARF


Bibliographic details
Hardbound, 1744 pages, publication date: DEC-2004
ISBN-13: 978-0-8151-4387-1
ISBN-10: 0-8151-4387-7
Imprint: MOSBY


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Last update: 30 Nov 2009
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