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Anthony Wood, Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, Kent, UK
Description Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry
together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future
therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize
important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals
market.
Audience
For medicinal, pharmaceutical and organic chemists
Contents I. CENTRAL NERVOUS SYSTEM DISEASES (A.J. Robichaud).
1. Novel approaches for the treatment of schizophrenia (B.N. Rogers, C.J. Schmidt).
2. Recent strategies for the development of new antidepressant drugs (D.A. Evrard).
3. Neuroprotective agents for the treatment
of ischemic and hemorrhagic stroke (S.N. Haydar, W.D. Hirst).
4. Novel sodium channel blockers for the treatment of neuropathic
pain (B. Marron).
II. CARDIOVASCULAR AND METABOLIC DISEASES (A. Stamford).
5. Centrally acting anti-obesity agents (D.
Hepworth et al.).
6. Nuclear Hormone Receptor Modulators for the Treatment of Diabetes and Dyslipidemia (P.T. Meinke et
al.).
7. 11 α-Hydroxysteroid Dehydrogenase Type 1 Inhibitors (C.D. Boyle et al.).
8. Glucokinase Activators
for the Treatment of Type 2 Diabetes (P.S. Humphries, T.O. Johnson).
9. Renin Inhibitors (C.M. Tice).
10. Antiarryhthmic Agents
(M.J. Suto, D.S. Krafte).
III. INFLAMMATORY, PULMONARY, AND GASTROINTESTINAL DISEASES (M.G. Bock).
11. Progress in Anti-SARS
Coronavirus Chemistry, Biology and Chemotherapy (A.K. Ghosh et al.).
13. Recent advances in gastrointestinal prokinetic
agents (Hans-Jürgen Pfannkuche, D.A. Sandham).
14. PGD2 Antagonists (J.C. Medina, Jiwen Liu).
15. Progress in the Development
of Inhaled, Long Acting β2-Adrenoceptor Agonists (P.A. Glossop, D.A. Price).
IV. CANCER AND INFECTIOUS DISEASES (D. Myles).
16. The Acyl Sulfonamide Anti-Proliferatives and Other Novel Anti-Tumor Agents (M.M. Mader).
17. Progress on Mitotic Kinesin
Inhibitors as Anti-cancer Therapeutics (Xiangping Qian et al.).
18. Developing Infectious Disease Strategies for the Developing
World (P.J Lee et al.).
19. Influenza Neuraminidase Inhibitors as Antiviral Agents (Pooran Chand et al.).
20.
Recent Developments in Antifungal Drug Discovery (R. Di Santo).
V. TOPICS IN BIOLOGY Section Editor: (D. Cohen).
21.
Genomic Data Mining and its impact on drug discovery (N.R. Nirmala).
22. HTS of cDNA and RNAi for target identification (M.A. Labow).
23. Genomic Approaches to identify molecular basis of multi-factorial diseases (C. Kumar).
VI. TOPICS IN DRUG DESIGN AND DISCOVERY
(Manoj C. Desai).
24. Structure Activity Relationships for in vitro and in vivo Toxicity (J. Blagg).
25. Importance of Early
Assessment of Bioactivation in Drug Discovery (Cornelis E.C.A. Hop et al.).
26. The Application of Pulmonary Inhalation
Technology to Drug Discovery (A.R. Clark et al.).
27. Recent Advances in Oral Prodrug Discovery (Aesop Cho).
28. Oxytocin
Antagonists and Agonists (A.D. Borthwick).
VII.TRENDS AND PERSPECTIVES (A. Wood).
29. Knowledge and Intelligence in Drug
Design (A. Hopkins, A, Polinsky).
30. To Market, To Market – 2005 (S. Hegde, M. Schmidt).
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