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| ARTERIAL STIFFNESS IN HYPERTENSION, 23
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Handbook of Hypertension Series
To order this title, and for more information, click here
By
Michel Safar, MD, Chef de Service, Centre de Diagnostic, Hopital Hotel-Dieu, Paris, France
Michael O'Rourke, MD, DSc, Emeritus Professor of Medicine, University of New South Wales Cardiologis, St Vincent's Hospital, Sydney Head, Ventricular-Vascular
Interaction Group, Vicotr Chang REsearch Institute, Sydnedy, Australia
Included in series
Handbook of Hypertension,
Contents
I: Basic concepts of pulsatile arterial hemodynamics
Principles and definitions of arterial stiffness, wave reflections
and pulse pressure amplification. Large arteries, microcirculation and the mechanism of hypertension. Direct measurement of local arterial
stiffness and pulse pressure. Determination of systemic and regional arterial stiffness. Interrelations of structure and function of
large arteries in epidemiology.
II: Pathophysiological mechanisms
Mechanical stress and the arterial wall.
Pulsatile stress, arterial stiffness and endothelial function. Endothelial-dependent vascular modulation by pulse perfusion. Central
arterial aging: humans to molecules. Elastin, calcium and the arterial wall. Animal models for studies of arterial stiffness. Renin-angiotensin
system, large arteries and micro-circulation. Arterial distensibility and the sympathetic nervous system.
III: Arterial
stiffness, wave reflections, cardiovascular risk and end-organ damage
Brachial and central pulse pressure and cardiovascular
risk. Large artery stiffness and cardiovascular risk: introduction to risk assessment and new strategies. Small artery elasticity index,
endothelial function and cardiovascular risk. Genetic aspects of arterial stiffness and pulse pressure in clinical hypertension. Heart
rate, pulse pressure and arterial stiffness. The relation of large arterial structure and function to cardiac hypertrophy in hypertension.
Arterial stiffness in chronic heart failure. Arterial stiffness and various cardiovascular diseases . Arterial function in end-stage
renal disease. Arterial changes in renal transplantation.Carotid intima-media thickness and arterial stiffness.
IV:
Clinical aspects of arterial stiffness and wave reflections
Aging: a physical perspective. Hypertension in women: is it different.
Arterial stiffness and wave reflections at the different stages of the hypertensive vascular disease. Diabetes, lipids and other cardiovascular
risk factors.
V: Therapeutic aspects of arterial stiffness and wave reflections
Antihypertensive drug treatment
and cardiovascular prevention: an update including the 2003?2004 secondary prevention trials. Changing concepts on the role of blood
pressure reduction in cardiovascular prevention. Principles of measurement, of preventing, and of treating arterial stiffness. Nitrates
and endothelial function. De-stiffening strategy using sodium balance and blockade of the rennin?angiotensin system. Aldosterone antagonists,
arterial stiffness and wave reflections. Drugs acting on collagen cross-linking. Long term effects of converting enzyme inhibitors, calcium
antagonists and beta blocking agents on peripheral and central arteries. Statins and arterial stiffness. Non-pharmacological treatment
of increased arterial stiffness and altered wave length reflections.
| Bibliographic details |
Hardbound, 624 pages, publication date: MAR-2006
ISBN-13: 978-0-444-51758-6
ISBN-10: 0-444-51758-8
Imprint: ELSEVIER
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999/999
Last update: 13 Jun 2009
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