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| THE REGULATORY GENOME
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 Gene Regulatory Networks In Development And Evolution
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By
Eric Davidson, California Institute of Technology, Pasadena, U.S.A.
Description
Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution
has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship.
He is a world renowned scientist and a major contributor to the field of developmental biology.
The Regulatory Genome beautifully
explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent
properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived
from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore
each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive
developmental biology. This unique text supersedes anything currently available in the market.
Contents
CHAPTER 1
The "Regulatory Genome" for Animal Development
THE FRAMEWORK
THE REGULATORY APPARATUS ENCODED IN THE DNA
Genomes,
Genes, and Genomic "Space"
Overview of Regulatory Architecture
Gene Regulatory Networks
THE REGULATORY DEMANDS OF DEVELOPMENT
Readout
and Generation of Regulatory Information in Development; Specification
Spatial Gene Expression
From Regional Specification to Terminal
Differentiation
EVOLUTION, DEVELOPMENT, AND THE REGULATORY GENOME
CHAPTER 2
cis-Regulatory Modules, and the Structure/Function Basis
of Regulatory Logic
GENERAL OPERATING PRINCIPLES
MODULARITY, A GENERAL PROPERTY OF GENOMIC cis-REGULATORY CONTROL UNITS
INSIDE
THE cis-REGULATORY MODULE: LOGIC PROCESSING AND INPUT/OUTPUT RELATIONS
cis-Regulatory Logic Processors: Examples
Target Site Occupancy
and Transcriptional Output
Generalization: The Combinatorial cis-Regulatory Logic Code
cis-REGULATORY DESIGN
Integration of Spatial
Inputs at the cis-Regulatory Level
Repression and the Diversity of cis-Regulatory Design
cis-Regulatory Design and the Creation of
Spatial Complexity in Development
CONTROL BY SEQUENCE SPECIFIC INTERACTIONS AMONG DISTANT cis-REGULATORY ELEMENTS
Development and Basal
Transcription Apparatus Specificity
Control Functions of Sequence-Specific, Intra- and Inter-Genic Genomic Looping
CHAPTER 3
Development
as a Process of Regulatory State Specification
DEVELOPMENTAL PROCESSES OF THE PREGASTRULAR EMBRYO
Vectorial Embryogenesis
Maternal
Anisotropy and External Cues for Axial Polarity
Spatial Regulatory Complexity and Interblastomere Signaling
Territories
COMPARATIVE
VIEW OF EMBRYONIC PROCESSES, AND THE ORGANIZATION OF THE UNDERLYING GENE REGULATORY NETWORKS
Shallow Gene Regulatory Networks of Type
1 Embryos
More Complex Forms of Embryonic Process
REGULATORY STATE AND NETWORK CIRCUITRY IN BUILDING ADULT BODY PARTS
Steps in the
Postembryonic Developmental Process
The Progenitor Field Concept
Subdivision of the Progenitor Field Regulatory State
BODY PLAN DEVELOPMENT
AND THE ORGANISM
CHAPTER 4
Gene Regulatory Networks for Development: What They Are, How They Work, and What They Mean
GENERAL
STRUCTURAL PROPERTIES OF DEVELOPMENTAL GENE REGULATORY NETWORKS
Gene Regulatory Networks from Different Perspectives: Subcircuits to
Process
Diagrams
Qualitative Diversity of Network Components
Extensions
GENE REGULATORY NETWORKS FOR EMBRYONIC DEVELOPMENT
The
Sea Urchin Endomesoderm Network
Regulatory Gene Network for Specification of Mesoderm in the Xenopus Embryo
Gene Regulatory Network
Controlling Dorsal-Ventral Territorial Specification in the
Drosophila Embryo
NETWORKS THAT CONTROL CONSTRUCTION OF COMPONENTS OF
ADULT BODY PARTS
Network Organization in the Specification of Pancreatic ?O-cells
Cell fate exclusion by microRNAs in a gene regulatory
network controlling terminal
differentiation in C. elegans taste neurons
CONCLUDING REMARKS
CHAPTER 5
Gene Regulatory Networks:
The Roots of Causality and Diversity in Animal Evolution
EVOLUTIONARY IMPLICATIONS OF THE STRUCTURE AND FUNCTION OF GENE REGULATORY
NETWORKS
The Parts of Gene Regulatory Networks, and the Qualities of Evolutionary Change
Linnaean Framework for the Evolutionary Consequences
of Alterations in Gene
Regulatory Networks
BILATERIAN KERNELS, PREDICTED AND REAL
Caveats and a Caution
Regional Specification in
the Bilaterian Nervous System
The Bilaterian Gut
A Possible Pan-Bilaterian Kernel Underlying Specification of the Heart Progenitor
Field
Distribution of Kernels
SUBPHYLETIC EVOLUTION OF BILATERIAN BODY PLANS: HOX GENES AS SOURCES OF LABILE NETWORK INPUT/OUTPUT
SWITCHES
Diverse Functional Consequences of hox Gene Expression
Multiple Examples: Regional Repression and Installation of Patterning
Output, and
the Evolutionary Diversification of Body Parts
Hox Gene Subnetworks and Spatial Evolution
METAZOAN ORIGINS AND GENE NETWORKS
BEFORE KERNELS
"Deconstructing" Bilaterian Gene Regulatory Networks in Time
Concluding Reflection: the Principle of Animal Development
and Evolution
| Bibliographic details |
Hardbound, 304 pages, publication date: MAY-2006
ISBN-13: 978-0-12-088563-3
ISBN-10: 0-12-088563-8
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
EUR 57.95
USD 75.95
GBP 45.99
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Last update: 8 Nov 2008
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