CYCLIC GMP: SYNTHESIS, METABOLISM, AND FUNCTION, 26
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J. August, John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A. Ferid Murad, University of Texas Medical School, Houston, U.S.A. M. Anders, University of Rochester; Department of Pharmacology, New York, U.S.A.
Description This volume is dedicated to the topic of cyclic GMP. Chapters include discussions on the guanylyl cyclase and phosphodiesterase isoenzyme
families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate
cyclic GMP formation and/or metabolism. Several chapters also deal with some of the effects of cyclic GMP on other second messengers
such as calcium ion transport and smooth muscle relaxation. Some clinical studies with cyclic GMP and atrial natriuretic peptide are
also discussed. The last chapter raises many important questions in the field that remain to be addressed.
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