NEW FRONTIERS IN MEDICAL SCIENCES: REDEFINING HYALURONAN
Proceedings of the Symposium on New Frontiers in Medical Sciences, Padua, 17-19 June 1999
Edited by G. Abatangelo, Institute of Histology & Embryology, Padova, Italy P.H. Weigel, University of Oklahoma Health Sciences Center, Department of Biochemistry & Molecular Biology, Oklahoma City, OK, USA
Description Although hyaluronan was discovered nearly 70 years ago and has been investigated by thousands of scientists, it is very appropriate that
as we enter a new millennium, the study of the biology and chemistry of hyaluronan has entered a renaissance period. The driving force
behind the symposium was to redefine the properties and complex biological roles of hyaluronan, its interactions with other molecules
of the extracellular matrix and its increasing use to treat various pathologies. For many decades hyaluronan was considered to be merely
a structural component of many tissues, certainly important for the normal function of our eyes and joints, but of relatively little
interest to scientists trying to understand complex multicellular processes. That view has been dramatically changed by several unexpected
discoveries: that several cell surface receptors specifically recognize hyaluronan; that small hyaluronan oligosaccharides stimulate
angiogenesis; that hyaluronan can initiate signal transduction cascades in certain cell types and modify their behavior; and that certain
cells, particularly macrophages, will respond to hyaluronan only if it is of an appropriate size. The emerging concept that cellular
responses to hyaluronan may depend on the size of the hyaluronan represents a real revolution in the field. In addition, a major recent
research impetus has been to develop novel ways to chemically modify hyaluronan. This new technology has given rise to many derivatives
with innovative applications in medicine and, particularly, in the new frontier of tissue engineering.
The scope of this book is very
broad: ranging from the interactions of hyaluronan at the molecular level to the very complex interactions that occur with multiple cell
types or tissues during cartilage repair and wound healing. The diverse chapters give an excellent overview of the biology and chemistry
of hyaluronan and especially how it enhances the ability of the body to heal.
Audience
Perfect for professionals working in wound healing or tissue engineering, in the biotechnological, drug delivery and biomedical applications
of hyaluranon and students and researchers seeking a comprehensive overview of this multi-faceted field.
Contents Preface.
Biology of Hyaluronan.
Why hyuronan has so many biological activities
(E.A Balazs).
Secondary and tertiary structures
in solutions of hyaluronan and related 'shape module' anionic glycosaminoglycans
(J.E. Scott).
Roles of inter-α-trypsin inhibitor
and hyaluronan -binding proteoglycans in hyaluronan-rich matrix formation
(M. Yoneda et al.).
Does keratinocyte hyaluronan
determine the volume of extracellular space in the epidermis?
(V. Hascall et al.).
Streptococcal hyaluronan synthases and the
synthesis of "designer" hyaluronan
(C. Heldermon et al.).
Perturbation of hyaluronan-tumor cell interactions inhibits tumor
growth and metastasis
(B.P. Toole et al.).
The extracellular matrix receptors CD44 and RHAMM regulate signaling pathways leading
to tumor cell motility and invasion
(U. Ågren et al.).
Is hyaluronan degradation an angiogenic/metastatic switch?
(D.
West, H. Chen).
Medical applications of hyaluronan.
Why viscoelasticity is important for the medical use of HA and Hylans
(C.
Weiss).
Symptomatic and structural effects of hyaluronan therapy in knee osteoarthritis
(E. Paresce, M. O'Regan, M. Dougados).
Structural
parameters of the human knee synovial membrane in oseteoarthritis before and after hyaluronan treatment
(I. Pasquali Ronchetti et
al.).
Hyaluronan in rheumatoid arthritis: a review
(P. Prehm).
Mechanism of the action of hyaluronan in joint diseases
(L. Punzi et al.).
Hyaluronic acid in osteoarthritis: state of the art and perspectives
(M. Carrabba et al.).
Mechanisms of
drug release from hyaluronic acid esters
(L.G. Rajewski et al.).
Hyaluronic acid biopolymers for mucosal delivery of vaccines
(M. Singh, M. Briones, D.T. O'Hagan).
Chemical modifications of hyaluronan.
New routes to hyaluronan based networks and supramolecular
assemblies
(V. Crescenzi, M. Tomasi, A. Francescangeli).
Chemically-modified hyaluronan: new biomaterials and probes for cell biology
(G.D. Prestwich et al.).
Hyaluronic acid derivatives mimic the rheological properties of vitreous body
(A. Borzacchiello et
al.).
Hyaluronan derivatives: chemical modifications and biochemical applications
(R. Barbucci et al.).
Hyaluronan-based
biomaterials in skeletal tissue repair.
Osteogenesis in vitro and in vivo with hyaluronan and bone morphogenetic protein-2
(G.W.
Bernard et al.).
Hyaluronic acid-based biomaterials in tissue engineered cartilage repair
(L.A. Solchaga, V.M. Goldberg, A.I.
Caplan).
Hondrogenic differentiation of mesenchymal stem cells on matrices of hyaluronan derivatives
(F.P. Barry, J.M. Murphy).
Cartilage
tissue engineering with scaffolds based on hyaluronan benzyl esters for reconstructive head and neck surgery
(J. Aigner et al.).
Hyaluronan-based biomaterials in cutaneous tissue repair.
Hyaluronan-based biomaterials in tissue engineering
(P. Brun et
al.).
Biological rationale for the application of hyaluronan in wound healing
(H.A. Navsaria).
The role of hyaluronan in fetal
repair: a review
(J.A. Iocono, T.M. Krummel).
Clinical challenges and promises of HYAFF® technology in would healing
(K. Harding).
Benzylester hyaluronic acid membranes: a delivery system for autologous keratinocyte cultures in the treatment of complicated
chronic and acute wounds
(D.A. Hollander et al.).
Tissue engineering in the treatment of diabetic foot ulcers
(C. Caravaggi et al.).
Epidermal cultures for the surgical treatment of vitiligo
(E. Pianigiani et al.).
Hyaluronan-based derivatives
in adhesion prevention.
Hyaluronan in the prevention of post-surgical adhesions
(M.P. Diamond, K.S. Moghissi).
Prevention of adhesions
in abdominal surgery
(M. Lise et al.).
Adhesion prevention in gynecological surgery: preclinical and clinical studies
(P. De
Iaco et al.).
Hyaluronan-based derivatives as surgical adjunctions.
The potential use of hyaluronan based compounds
in laryngeal augmentative surgery
(L. Hallén et al.).
Versatility of hyaluronan in the ENT field. Critical evaluation
of the clinical data
(B. Morra).
Index of authors.
Keyword index.
Books and book related electronic products are priced in US dollars (USD), euro (EUR), and Great Britain Pounds (GBP). USD prices apply to the Americas and Asia Pacific. EUR prices apply in Europe and the Middle East. GBP prices apply to the UK and all other countries.
Proceedings of the Symposium on New Frontiers in Medical Sciences, Padua, 17-19 June 1999
