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| FRONTIERS OF THE MECHANISMS OF MEMORY AND DEMENTIA
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 Proceedings of the 16th Yokohama 21st century Forum on Brain Science in the Coming Century, Viamale, Yokohama, Japan, 10-12 November 1999
Edited by
Takeshi Kato, Laboratory of Molecular Recognition, Graduate School of Integrated Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan
Included in series
International Congress, 1200
Description
This volume contains presentations of the 16th Yokohama 21st Century Forum on Brain Sciences in the Coming Century,
entitled "Frontiers of the Mechanisms of Memory and Dementia" held in Japan in November 1999. The symposium included 19 invited
speakers and 53 poster presentations. Over 150 scientists from around the world attended the meeting.
Main features of this monograph
cover the molecular mechanisms of long-term potentiation, the mechanisms of cell death and apoptosis and the recent research on memory
and dementia.
Multiple mechanisms have been proposed to mediate memory and learning encompassing molecular, neurochemical, neuronal,
synaptic, network, neural systems and behavioral processes.
The purpose of this volume is to review the state of knowledge in the
topics of memory, cell death, neuroprotection, animal models of memory impairment, neuropathology and neuroimaging of dementing illness
and dementia therapy. Dysfunction at any level may result in neurodegeneration, memory impairments or dementia. Unresolved issues, however,
will stimulate further scientific inquiry. Elucidation of the neurobiological substrates of memory and memory disorders has indeed become
a scientific endeavor of increasing importance and prominence.
Audience
Professionals in the field of Neurology and Neurosciences
Contents
Preface.
A. Memory, Learning.
Learning by microbrain - from the study of color vision in Papilio (K. Arikawa, M. Konoshita).
Molecular mechanisms for plasticity of hippocampal synaptic transmission (T. Manabe).
Endogenous corticotropin-releasing factor (CRF)
is required for the induction of cerebellar long-term depression (M. Kano et al.).
Coding and processing of odor molecular features
in the mammalian main olfactory bulb (K. Mori).
Cerebral mechanisms of retrieval of memories (A. Yamadori et al.).
Functional
MRI of Literacy (T. Nakada).
Long-term potentiation and olfactory memory formation in the carp of olfactory bulb (M. Huruno, M. Satou).
Am in vitro study of long-term potentiation in the carp olfactory bulb (R. Hoshikawa, Y. Sato, M. Satou).
Role of cyclic AMP-dependent
protein kinase in the hippocampal-prefrontal cortex long term potentiation (T. Yamaguchi, H. Gurden, T.M. Jay).
Exposure to acute psychological
stress stimuli produces the enhancement of memory storage via hypothalamo-pituitary-adrenal axis (H. Takeda et al.).
A spatial
recognition impairment following cerebral ischemia. Correlation between learning memory and acetylcholine level or learning acquisition
and acetylcholine level (H. Kanemitsu et al.).
B. Transmitter, Receptor, Channel, Signal Transduction.
[3H]TCP Discriminates
the multiple states of NMDA receptor/ion-channel complex: a comparison between [3H]TCP and [125]iodo-MK-801 bindings in rat cortical
membranes (T. Yamamoto, T. Moroji, H. Yamamoto).
Microautoradiography of L-[3H]DOPA uptake sites in the rat brain (Y. Sugaya et al.).
Effects of tizanidine, a centrally acting muscle relaxant, on spinal reflex potentials in rats, with special reference to imidazoline
receptors (Y. Sekiguchi, M. Honda, H. Ono).
Quantitative distribution of various neurochemicals in the human brain using a human brain
mapping analyzer (D. Sutoo, K. Yabe. K. Akiyama).
Analysis of the functional receptor in living cells, utilizing microspot photolysis
of caged compounds (A. Watanabe et al.).
Novel caged functional groups and caged glutamic acid (H. Shiono, A. Watanabe, H. Nohta).
Differential effect of lithium chloride on intracellular calcium and c AMP in C6 glioma cells (A. Okada et al.).
Effect of neurosteroids
on cystosolic calcium in primary culture of rat hippocampal neuronal cells (M. Inagaki et al.).
Regulation of sodium pump isoform
activities in cultured cerebral neurons (N. Inoue, T. Soga, T. Kato).
Purification of neuropeptide processing enzymes from pig pituitary
anterior glands (M. Yamamoto et al.).
C. Ischemia, Apoptosis, Neurodegeneration.
ORP150 (150 kDa oxygen regulated protein)
suppresses hypoxia-induced cell death (K. Ozawa et al.).
Alterations of antioxidant status in the neurodegenerative models;
study for Parkinson's disease (H.-C. Kim, G. Bing).
Imaging monoamine oxidase in the human brain (J.S. Fowler et al.).
Lasalocid
induces cell death on NG 108-15 cells (T. Hama, H. Higashi. M. Maruyama).
Oligodendroglial cell death with DNA fragmentation in the white
matter of chronically hypoperfused Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) (M. Masumura et al.).
Neuronal
cell death in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice (T. Fukuda et al.).
Neuronal death inhibitor and its
signal transduction (H. Ueda et al.).
Kinetic analysis of nitric oxide (NO) release from several NO-donors using flourescence
dye, diaminoflourescein-2 (DAF-2) (C. Tamura et al.).
D. Disorder, Animal Model, Behavior.
An animal model for Alzheimer's
disease using racemic β-amyloids and excitatory amino acids (I. Kaneko et al.).
Effect of repeated administration with estrogen
on serotonin-2A receptor-mediated behavior in rats (S. Nakae et al.).
Effects of single and repeated phencyclidine administration
on the expression of subunit mRNA for NMDA receptors in rat brain (S. Abe et al.).
Effects of single and repeated administration
of cocaine on NMDAR1 and m GluR5 subunits of glutamate receptors in rat brains (M. Yamaguchi et al.).
Characteristic dopamine
metabolism, dopamine receptors and dopamine transporters in the striatum of high and low aggressive mice substrains (T. Morimasa).
The
mechanism by which exercise reduces blood pressure (K. Akiyama, D. Sutoo).
Analysis of DNA polymerase β deficient mice with neuronal
abnormality (N. Sugo et al.).
Behavioral analysis of chronic hypoperfused rats as a cerebrovascular-type dementia animal model
(K. Tanaka et al.).
Effects of NMDA and MK-801 on acetylcholine release in the dialysate of rat cerebral cortex (T. Kato et
al.).
Effects of dynorphin fragments on learning and memory impairment induced by carbon monoxide exposure and β-amyloid peptide
(25-35) in mice (M. Hiramatsu, K. Inoue, T. Kameyama).
E. Aging, Dementia, Alzheimer's.
Mechanism of neurodegeneration in the
brain of presenilin-1 knock-in mice (M. Takeda et al.).
The initial phase of amyloid β-protein (Aβ) accumulation in
the human brain (Y. Ihara).
Our recent studies on dementia with Lewy bodies (K. Kosaka, E. Iseki).
Quantitative neuropathological assessment
of Alzheimer disease and amyloid precursor protein transgenic mice (M.C. Irizarry et al.).
Protein aggregation in neurodegenerative
disorders: Alzheimer's disease and Parkinson's disease (T. Iwatsubo).
Characterization of the 5'- flanking promoter region of the human β-amyloid protein precursor like protein 2 gene (S. Nagumo et al.).
Alzheimer's amyloid precursor protein and its derivatives
in PC12D cells transfected presenilin-1 with and without a missense point mutation (F. Kametani et al.).
Membrane-topological
analysis of the C-terminal region of Alzheimer's disease-related presenilin 1 (A, Yamasaki et al.).
Longitudinal evaluation
of hippocampal gray-matter volume and hippocampal blood flow in Alzheimer's disease--changes in 16 patients in 1 year follow-up studies--(N.
Kitayama et al.).
Identification and development of metallothionein-1, -2 and metallothionein-3 (GIF) immunoreactive cells in
rat hypothalamus on course of aging (T. Watanabe et al.).
F. Neurotrophin, Regeneration, Differentiation.
Neuronal nitric
oxide synthase supports the cell proliferation and differentiation (T. Kato et al.).
Cytokines and neurotrophins in Parkinsonian
brain (M. Mogi et al.).
Expression of m RNAs for neuropeptide receptors, adrenergic receptors, neurotrophins and semaphorin
III in human osteoblasts and osteoclasts (A. Togari et al.).
Regulation of extraneuronal dopamine transporter activity by basic
fibroblast growth factor and epidermal growth factor in astrocytes (H. Takeda et al.).
A synthetic metalloproteinase inhibitor
accelerates the neurite outgrowth of NGF-stimulated PC12 cells by inhibiting the proteolytic shedding of p75 neurotrophin receptor (T.
Kosaka et al.).
Signal transduction pathway of bFGF on cell survival and proliferation of PC12 cells in culture (T. Yamaguchi,
T. Kawamata, K. Shin-ya).
Effect of neurotrophic factors on neural activity in cultured rat cortex (K. Torimitsu et al.).
Stimulation
of neurite outgrowth by laminin-5, the basement membrane cell adhesion protein (C. Yasuda et al.).
Role of Cdk5 and tau phosphorylation
in retinal growth cone collapse (T. Nakayama. Y. Goshima, T. Kato).
Axonal transports of deamidase and PZ-peptidase in rat sciatic nerves
(A. Yamashita et al.).
G. Drug Therapy, Pharmacology.
Enzyme inhibitor therapy for Alzheimer's disease (K. Toide, T.
Kato).
The effect of Ginkgo biloba extract (GbE) on impairment of memory and learning (T. Tadano et al.).
Therapeutic effects
of aniracetam in animal models of various mental dysfunctions after cerebral after cerebral infarction (Y. Tanaka et al.).
Nicotinic
ACh receptors as a target of the nootropic nefiracetam (T. Nishizaki et al.).
Effects of vasopressin fragment analog NC-1900
on learning and memory (T. Sato et al.).
Neuroprotection through blockade of NMDa receptors by gluconate in hippocampal organotypic
cultures (T. Sakaguchi, M. Kuno, K. Horikomi).
N-anisoyl-GABA-induced acetylcholine release in the brain of SHRSP and possible involvement
of group II metabotropic glutamate receptors (M. Shirane, K. Nakamura).
Serum contents of free forms of α1-microglobulin and ulinastatin:
useful objective indices on the diseased state in patients with mood disorders (K. Kaku).
Index of authors. Keyword index.
| Bibliographic details |
Hardbound, 228 pages, publication date: MAR-2000
ISBN-13: 978-0-444-50382-4
ISBN-10: 0-444-50382-X
Imprint: EXCERPTA MEDICA
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