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| BIOLOGICAL PSYCHIATRY, 14
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Edited By
Edward Bittar, Department of Physiology, University of Wisconsin Medical School, Madison, USA
Included in series
Principles of Medical Biology,
Description
It is now widely recognised that biological psychiatry is rapidly coming into its own. For over the last three decades dramatic advances
in this young discipline have been made, all of which attest to the staying power of the experimental method. Those who made this revolution
in knowledge happen are a breed of investigators availing themselves of the tools of molecular biology, pharmacology, genetics, and perhaps,
above all, the technology of neuroimaging. The introduction of the interdisciplinary method of approach to the study of psychopathology
had made it very clear that neuroimaging, as a set of techniques, is unique in that it is gradually providing us with evidence supporting
Kraepelin's original view that mental illness is closely associated with abnormal changes in the brain.
Broadly speaking, there are presently
two structural techniques in neuroimaging - computed tomography and magnetic resonance imaging (MRI) - and three functional techniques
- single photon emission tomography (SPECT), positron emission tomography and magnetic resonance imaging (fMRI). Through PET technology,
for example, we have learned that, in early brain development, the primitive areas, mostly the brain stem and thalamus, are the first
to show high activity in an infant. This is followed by the development of cortical areas by year one. Between the ages of four to 10,
the cortex is almost twice as active in the child as in the adult. This information alerts us to what might happen in the way of trauma
in abused children, especially those under the age of three. Child abuse increases the risk of physical changes, not only in the stress
systems, but also in brain development (Glaser and Weissman). In addition to the difficult problem of post-traumatic stress disorder
(PTSD), we have to take into account the possibility of other types of mental illness as the consequences of child abuse. These include
depression, eating disorders, and drug and alcohol problems.
The combination of PET and fMRI represents a more remarkable example of
the power of neuroimaging since the two have made it feasible to map accurately in vitro identifiable cortical fields, or networks. In
a landmark NIH investigation of human cortical reorganization (plasticity), persuasive evidence was brought forward showing that the
process of learning as a motor task involves a specific network of neurons. These neurons occur in the cortical field that is responsible
for that particular task. Such findings are important partly because they provide evidence supporting the current notion that labor in
the cortex is divided among ensembles of specialized neurons that cooperate in the performance of complex tasks. Cooperation, then, in
this, sense implies crosstalk among ensembles and that signals are both processed and retransmitted to neighbouring ensembles. To understand
the workings of these ensembles, much better spatial and temporal resolution in functional brain mapping is required. This can be achieved
with an NMR instrument whose magnet is 4.1 Tesla or more.
Contents
Contents. List of Contributors. Preface (E.E. Bittar and N. Bittar). Consciousness (T.W. Picton and D.T. Stuss). Emotional Circuits of
the Mammalian Brain: Implications for Biological Psychiatry (J. Panksepp). The Sexual Brain (W. Byne and E. Kemmether). The Biology of
Personality (R.T. Mulder). The Biology of Aggression (P.F. Brain). Psychological Aspects of Hypothalamic-Pituitary-Adrenal Axis Activity
(E. Ur). Stress and the Immune System (C.M. Pariante and A.H. Miller). Fear and Anxiety Mechanisms of the Brain: Clinical Implications
(J. Panksepp). Biological Aspects of Depression (B.E. Leonard). Psychobiology of Suicidal Behavior (K.M. Malone). Bipolar Disorder (J.C.Y.
Chou and R. Cancro). The Biological Basis of Schizophrenia (P. Winn). Heterogeneity of Schizophrenia: Diagnostic and Etiological Approaches
(M.T. Tsuang, M.J. Lyons, and R. Toomey). Child and Adolescent Psychiatry: General Principles (C.E. Kaplan and A. Thompson). Major Disorders
in Child Psychiatry (C.E. Kaplan and A. Thompson). Child Sexual Abuse (M. Wiseman and D. Glaser). Hereditary and Acquired Mental Retardation
(J. Stern). Autism (C. Gillberg). Personality Disorders (P. Tyrer and K. Evans). Alcoholism, Alcohol Abuse and Alcohol Dependence (D.H.
Overstreet and A.B. Kampov-Polevoy). Homelessness and Mental Illness (J. Scott). Eating Disorders: Anorexia Nervosa and Bulimia Nervosa
(D.S. Goldbloom). Antidepressant and Anxiolytic Drugs (S.C. Cheetham and D.J. Heal). Lithium Use in Clinical Practice (D.L. Dunner and
J.J. Neumaier). Antipsychotic Drugs (B.K. Colasanti). Introduction to Electroconvulsive Therapy (A.P. Zis). Index.
| Bibliographic details |
Hardbound, publication date: DEC-1999
ISBN-13: 978-1-55938-819-1
ISBN-10: 1-55938-819-6
Imprint: ELSEVIER
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| Price and Ordering |
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EUR 114
USD 135
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Last update: 8 Nov 2008
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