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| ION CHANNEL REGULATION, 33
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Paul Greengard, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University
David Armstrong, National Institute of Environmental Health Science, Research Triangle Park, North Carolina, U.S.A.
Angus Nairn, Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, U.S.A.
Sandra Rossie, Purdue University, West Lafayette, Indiana, U.S.A.
Shirish Shenolikar, Durham, North Carolina, U.S.A.
Description
Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed
simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during
the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which
provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal
secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis,
and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost
100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential,
yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases.
How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of
the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that
control ion channel activity.
Audience
Cell biologists, biochemists, neuroscientists, pharmacologists, and biophysicists interested in ion channels.
Written specifically to
introduce non-electrophysiologists to ion channels as proteins and to introduce electrophysiologists to signal transduction pathways,
Ion Channel Regulation represents a unique professional summary of an important and exciting field and will attract and instruct anyone
interested in cell signaling through second messengers and phosphoproteins.
Contents
Overview:
I.B. Levitan, Modulation of Ion Channels by Protein Phosphorylation.
Protein Phosphorylation.S.
Rossie, Regulation of Voltage-Sensitive Sodium and Calcium Channels by Phosphorylation.S.L. Swope, S.J. Moss, L.A. Raymond,
and R.L. Huganir, Regulation of Ligand Gated Ion Channels by Protein Phosphorylation.D.C. Gadsby and A.C. Nairn, Regulations
of CFTR Cl- Ion Channels by Phosphorylation and Dephosphorylation.
Second Messengers:
M. Biel, X. Zong,
and F. Hofmann, Cyclic Nucleotide-Gated Channels.R.E. White, Cyclic GMP and Ion Channel Regulation.
Closely Associated
Proteins:
S.R. Ikeda and K. Dunlap, Voltage-Dependent Modulation of N-Type Calcium Channels: Role of G Proteins Subunits.
Novel Pathways.J.-L. Sui, K. Chan, M.-N. Langan, M. Vivaudou, and D.E. Logothetis, G Protein-Gated Potassium Channels.A.C.
Dolphin, L Type Calcium Channel Modulation by G Proteins.
Novel Pathways:
S.G. Rane, Ion Channels as Physiological
Effectors for Growth Factor Receptor and Ras/ERK Signaling Pathways.R.S. Lewis, Store-Operated Calcium Channels.
Subject Index.
| Bibliographic details |
Hardbound, 318 pages, publication date: APR-1999
ISBN-13: 978-0-12-036133-5
ISBN-10: 0-12-036133-7
Imprint: ACADEMIC PRESS
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| Price and Ordering |
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USD 136
GBP 81.99
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Last update: 3 Oct 2009
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