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| MOLECULAR BIOLOGY OF B CELLS
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Edited By
Tasuku Honjo, Kyoto University, Japan
Frederick Alt, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA
Michael Neuberger, Medical Research Council Laboratory of Molecular Biology
Description
Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged
in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear
understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive
reference is directed at research level immunologists, molecular biologists and geneticists.
Audience
Research level immunologists, molecular biologists and geneticists
Contents
ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENES
Human Immunoglobulin heavy chains locus
Immunoglobulin
heavy chain genes of mouse
Immunoglobulin – genes of human and mouse
Immunoglobulin lambdav (IGL) genes of human and mouse
The Mechanism
of V(D) J Recombination
Transcription of Immunoglobulin genes
B CELLS AND THEIR DEVELOPMENT
Early B cell development
to a mature , antigen-sensitive cell - cellular stages and molecular decisions
Allelic exclusion, Isotypic exclusion and the Developmental
Regulation of V(D)J Recombination
The Development of Human B Lymphocytes
Development and function of B cell subsets
B CELL DIFFERENTIATION
INDUCED BY Ag STIMULATION
Structure and function of B cells antigen receptor complexes
Regulation of antigen receptor signaling
by the co-receptors, CD19 and CD22
The dynamic structure of antibody responses
Dynamics of B cell migration to and within secondary lymphoid
organs
Characteristics of mucosal B cells with emphasis on the human secretory immune system
The Cellular Basis of B Cell Memory
Immunoglobulin
assembly and secretion
Fc And Complement Receptors
Ig GENE ALTERATION IN PERIPHERY
Regulation of Class Switch Recombination
Molecular Mechanism of Class Switch Recombination
Molecular Mechanism of Hypermutation
Selection During Antigen-Driven B Cell Immune
Responses: The Basis for High Affinity Antibody
DISEASES OF B CELLS
Chromosomal Translocations in B-cell Leukemias
and Lymphomas
Classification and Characteristics of Mouse B Cell-Lineage Lymphomas
B cells producing pathogenic autoantibodies
Immunodeficiencies
Caused by B Cell Defects
EVOLUTION OF Ig GENES
Diverse forms of Immunoglobulin Genes in Lower Vertebrates
Immunoglobulin
Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT
The zebrafish immune system
The Origin of V(D)J
Diversification
FUNCTION AND APPLICATION OF IMMUNOGLOBULINS
Antibody Structure and Recognition of Antigen
Monoclonal
antibodies from display libraries
Humanization of Monoclonal Antibodies
Human monoclonal antibodies from translocus mice
| Bibliographic details |
Hardbound, 600 pages, publication date: DEC-2003
ISBN-13: 978-0-12-053641-2
ISBN-10: 0-12-053641-2
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
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GBP 121
EUR 142.95
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092/941
Last update: 4 Sep 2009
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