Edited by
George Vande Woude, Director, Van Andel Research Institute, Grand Rapids, MI, USA
George Klein, Karolinska Insitutet, Stockholm, Sweden
Description
Volume 71 of
Advances in Cancer Research begins with Morgan and Kastan presenting data on the roles of p53 and ATM in
cell cycle progression and cell death in response to DNA damage and how this information may lead to targets for improved cancer therapies.
Kok
et all. Review the methodological advantages and limitations to localizing tumor suppressor genes, especially those on the
short arm of chromosome 3. Peltomaki and de la Chapelle describe research on mismatch repair genes and their effects on colorectal cancer.
McKenna and Cotter present findings on the functions and failures of apoptosis in the hematopoietic system. Ravitz and Wenner review
TGF-B and how it controls and affects cell cycle progression in a variety of cell types. Andrew Simpson presents data on the mutation
frequencies of microsatellites in human carcinogenesis. Naor and colleagues present research on a multitude of tumors expressing levels
of CD44 and discuss how CD44 may be used as a target for cancer therapy. Luisa Villa discusses various aspects of HPV and the potential
clinical use of HPV testing in cervical cancer prevention programs. Last, Disis and Cheever review the studies that define HER-2/neu
specific immunity in patients with cancer and the current vaccine strategies for generating specific immunity.
Included in series
Advances in Cancer Research
Audience:
Researchers and students in basic and clinical science of cancer biology and oncology, plus related areas in genetics, immunology, virology, cell biology, and molecular biology.
