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TOWARDS NATURAL MEDICINE RESEARCH IN THE 21ST CENTURY
Towards Natural Medicine Research in the 21st CenturyProceedings of the International Symposium on Natural Medicines, Kyoto, Japan, 28-30 October 1997

Edited by
H. Ageta, Shôwa College of Pharmaceutical Sciences, Tokyo, Japan
N. Aimi, Chiba University, Japan
Y. Ebizuka, The University of Tokyo, Japan
T. Fujita, Setsunan University, Osaka, Japan
G. Honda, Kyoto University, Japan

Included in series
International Congress, 1157

Description
This book contains papers presented at the International Symposium on Natural Medicines held in Kyoto, Japan on October 28 - 30, 1997. It commemorated the fiftieth anniversary of the Japanese Society of Pharmacognosy. The academic field of pharmacognosy; the science of natural medicines, covers a wide range of topics, including pharmaceutical botany, traditional medicines, and the biological activities and chemistry of natural products. Thus,Towards Natural Medicine Research in the 21st Century is of interest to chemists and biologists, as well as physicians. There is optimism that these reports will help provide a firm basis for future application of natural medicines as we head towards the 21st century.

Audience
Chemists, Biologists and Physicians

Contents


Pharmaceutical Botany.
Chemotaxonomy of ferns (H. Ageta et al.). Correlation of Tannin Structures with Plant Taxonomy and antitumor and antioxidants activities (T. Okuda). Triterpenes, Triterpene Esters and Triterpene Glycosides from Rhoiptelea chiliantha and Chemotaxonomy of Rhoipteleaceae (Z.-H. Jaing, T. Tanaka and I. Kouno). Phylogenetic relationship of Japanese Perilla (G. Honda, M. Ito). Regional differences of Indole Alkaloids in Alstonia scholaris and Alstonia macrophylla (T. Yamauchi, F. Abe). Cultivation of Croton sublyratus Kurz in Thailand (M. Siriphol et al.).

Pharmacognosy.
Development of antiviral agents from traditional medicines (T. Namba, K. Shiraki, M. Kurokawa). Design of immunosuppressant based on fungal metabolites (T. Fujita). Search for receptor blocking substances from natural resources and their pharmacological studies (Y. Ohizumi). African great ape self-medication: A new paradigm for treating parasite disease with natural medicines? (M.A. Huffman et al.). Novel plant constituents of biological interest (A.D. Kinghorn et al.). Triterpene glycosides with antidiabetogenic activity from sugar beet-Absolute stereostructures, structure-activity relationships and action mechanism (M. Yoshikawa, T. Murakami, H. Matsuda). The current status and the future of traditional Chinese medicine in Taiwan (M.-S. Lai). Elucidation of pharmacologically active polysaccharides from Kampo Medicines and component herbs (H. Kiyohara). A trial of searching for bioactive compounds from traditional oriental medicine (K. Saito, Y. Kano). Effects of taxoids for Taxus cuspidata on microtubule depolymerization and vincristine accumulation in MDR cells (J. Kobayashi et al.). Bioactive diterpenoids from a tropical herb, Scoparia dulcis L. (T. Hayashi et al.). Inhibitory effect of triterpenes from compositae plants on tumor promotion in two-state carcinogenesis in mouse skin (K. Yasukawa et al.). Inductive effects of constituents of Boswellia carterii Birdw. on the mouse liver glutathione S-Transferase (K. Wada et al.). Glycyrrhetic Acid Monoglucuronide (MGGR): Biological activities (K. Mizutani et al.). Hepatoprotective Oleanene Glucuronides in Fabaceae (J. Kinjo,T. Nohara). Formation of Monoclonal antibody against a major ginseng component, Ginsenoside Rb1 and its characterization (H. Tanaka, N. Fukuda, Y. Shoyama). Bioactive phenolics from licorice: Their radical-scavenging effects, inhibitory effects on oxidative enzymes and antiviral effects (T. Hatano, T. Yoshida). Urinary and biliary metabolites of Daidzin, Daidzein and Puerarin in rats (T. Yasuda, K. Ohsawa). Antioxidants from Lespedeza homoloba (I) (T. Miyase et al.). Search for naturally occurring substances for prevention against the complications of diabetes inhibitory effect on aldose reductase and platelet aggregation (Y. Okada et al.). Search for Anti-allergic principles from Malaysian medicinal plants downregulating the expression of cell adhesion molecules (S. Tanaka et al.). Anti-Emetic principles of Alpinia katsumadai (Y. Yang et al.). Studies on crude drugs effective on growth of Helicobacter pylori. Growth inhibitors in Kaempferiae Rhizoma (A. Inada et al.). Research on Anti-Tumor active site of marine source natural product, Halichondrin B (K. Horita, S. Nishibe, O. Yonemitsu).

Biosynthesis of Natural Products.
Recent progress toward an understanding of Taxol Biosynthesis in plant cell cultures (R.E.B. Ketchum, R.B. Croteau). Biosynthesis of Vitamin B6 and a structurally related toxin in Ginkgo biloba (C. Drewke, E. Leistner). The use of molecular approaches to produce phytomedicines in the Catharanthus roseus model system (V. De Luca et al.). Molecular Biology of alkaloid biosynthesis (T. Hashimoto et al.). Studies on the optically active Diels-Alder type adducts from Mulberry tree (T. Nomura, Y. Hano, S. Ueda). Cross reactions of chalcone and stilbene Synthases (T. Yamaguchi et al.). Chalcone synthase from Scutellaria baicalensis (H. Morita et al.). cDNA cloning of polyketide synthases from Hydrangea macrophylla var. thunbergii (T. Akiyama, M. Shibuya, Y. Ebizuka). Molecular cloning of oxidosqualene cyclase cDNA from Panax ginseng: the Isogene that encodes ß-Amyrin Synthase (T. Kushiro, M. Shibuya, Y. Ebizuka). Biosynthetic studies on steroid saponins (S. You et al.).

Phytochemistry of Natural Products.
Current status and prospects of research on natural products in China (X.-S. Yao et al.). The ongoing story of Cannabis Sativa: From Cannabis Resin to Cannabinoids, Anandamide and 2-Arachidonoyl Glycerol (R. Mechoulam). Chemical studies on cyclic peptides from higher plants (H. Morita). Solubilization and Insolubilization of Tannins (T. Tanaka). Abeotaxanes from Chinese Taxus Plants (K. Tanaka). New Taxoids from Taxus cuspidata var. nana (H. Morita et al.). Diterpene derivatives from the Japanese marine sponge Epipolasis sp. (A. Umeyama et al.). New Triterpenoid Saponins and Sapogenins from Vaccaria segetalis (Z. Jia et al.). Essential oils constituents from Curcuma aromatica, C. longa and C. xanthorrhiza rhizomes (H. Kojima et al.). Chemical modification of naturally occurring Ionophore, Monensin: Synthesis and an ion transport activity of Divalent Monensins (A. Nagatsu et al.). Geraniin-related Ellagitannins of the Euphorbiaceae (T. Yoshida, T. Hatano, H. Ito). Novel methods of structure determination of Prenylated Phenols with 1H- and 13C-NMR Spectra (T. Nomura, T. Fukai). The correlation between CD Spectra and C-3 Stereochemistries of some Monoterpenoid Glucoindole Alkaloids (O. Ohmori et al.).

Index of authors.


Bibliographic details
Hardbound, 596 pages, publication date: DEC-1998
ISBN-13: 978-0-444-82898-9
ISBN-10: 0-444-82898-2
Imprint: EXCERPTA MEDICA

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Last update: 26 Sep 2008
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