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Elsevier publications by Craig C. Mello
The Nobel Prize in Physiology or Medicine 2006

External link  "for their discovery of RNA interference - gene silencing by double-stranded RNA"

The genetic instructions contained within the genome are copied into strands of messenger RNA (mRNA), which subsequently serve as recipes for proteins. First discovered by Nobel laureates Andrew Fire and Craig Mello in 1998, RNA interference (RNAi) is a mechanism for controlling the flow of genetic information through the selective degradation of mRNA.

When particular mRNA molecules are lost through RNAi, no protein of that type is produced and the gene encoding that protein is effectively silenced. Fire and Mello's breakthrough came when they found that double-stranded RNA, made up of complementary "sense" and "anti-sense" strands, silenced genes with a matching code in the worm Caenorhabditis elegans.

Researchers have gone on to study the RNAi machinery and how it is regulated, and have found that the process plays important roles in controlling gene activity and defending against viruses. RNAi is now an important research tool for unraveling the function of genes. Scientists are also investigating RNAi-based drugs for a variety of diseases, ranging from cardiovascular disease to cancer.

The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans Current Biology, Volume 16, Issue 1, 10 January 2006, Pages 47-55 Masaki Shirayama, Martha C. Soto, Takao Ishidate, Soyoung Kim, Kuniaki Nakamura, Yanxia Bei, Sander van den Heuvel and Craig C. Mello
PDF (753 K)    External link  Abstract via ScienceDirect

The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans Current Biology, Volume 16, Issue 1, 10 January 2006, Page 118 Masaki Shirayama, Martha C. Soto, Takao Ishidate, Soyoung Kim, Kuniaki Nakamura, Yanxia Bei, Sander van den Heuvel and Craig C. Mello
PDF (23 K)    External link  Abstract via ScienceDirect

A Member of the Polymerase β Nucleotidyltransferase Superfamily Is Required for RNA Interference in C. elegans Current Biology, Volume 15, Issue 4, 22 February 2005, Pages 378-383 Chun-Chieh G. Chen, Martin J. Simard, Hiroaki Tabara, Daniel R. Brownell, Jennifer A. McCollough and Craig C. Mello
PDF (460 K)    External link  Abstract via ScienceDirect

The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos Developmental Biology, Volume 265, Issue 1, 1 January 2004, Pages 127-139 Ka Ming Pang, Takao Ishidate, Kuniaki Nakamura, Masaki Shirayama, Chris Trzepacz, Charlotte M. Schubert, James R. Priess and Craig C. Mello
PDF (1858 K)    External link  Abstract via ScienceDirect

Chromatin regulation during C. elegans germline development
Current Opinion in Genetics & Development, Volume 13, Issue 5, October 2003, Pages 455-462 Tae Ho Shin and Craig C Mello
PDF (235 K)    External link  Abstract via Science Direct

MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans Cell, Volume 111, Issue 7, 27 December 2002, Pages 991-1002 Yingdee Unhavaithaya, Tae Ho Shin, Nicholas Miliaras, Jungsoon Lee, Tomoko Oyama and Craig C. Mello
PDF (496 K)    External link  Abstract via Science Direct

SRC-1 and Wnt Signaling Act Together to Specify Endoderm and to Control Cleavage Orientation in Early C. elegans Embryos Developmental Cell, Volume 3, Issue 1, July 2002, Pages 113-125 Yanxia Bei, Jennifer Hogan, Laura A. Berkowitz, Martha Soto, Christian E. Rocheleau, Ka Ming Pang, John Collins and Craig C. Mello
PDF (752 K)     External link  Abstract via Science Direct

The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans Cell, Volume 109, Issue 7, 28 June 2002, Pages 861-871 Hiroaki Tabara, Erbay Yigit, Haruhiko Siomi and Craig C. Mello
PDF (453 K)    External link  Abstract via Science Direct

11 RNAi (nematodes: Caenorhabditis elegans) Advances in Genetics, Volume 46, 2002, Pages 339-360 Alla Grishok and Craig C. Mello
PDF (4585 K)    External link  Abstract via Science Direct

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing Cell, Volume 106, Issue 1, 13 July 2001, Pages 23-34 Alla Grishok, Amy E. Pasquinelli, Darryl Conte, Na Li, Susan Parrish, Ilho Ha, David L. Baillie, Andrew Fire, Gary Ruvkun and Craig C. Mello
PDF (466 K)    External link  Abstract via Science Direct

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans Cell, Volume 99, Issue 2, 15 October 1999, Pages 123-132 Hiroaki Tabara, Madathia Sarkissian, William G. Kelly, Jamie Fleenor, Alla Grishok, Lisa Timmons, Andrew Fire and Craig C. Mello
PDF (264 K)   External link   Abstract via Science Direct

MOM-4, a MAP Kinase Kinase Kinase–Related Protein, Activates WRM-1/LIT-1 Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans Molecular Cell, Volume 4, Issue 2, August 1999, Pages 275-280 Tae Ho Shin, Jun Yasuda, Christian E. Rocheleau, Rueyling Lin, Martha Soto, Yanxia Bei, Roger J. Davis and Craig C. Mello
PDF (157 K)     External link  Abstract via Science Direct

WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans Cell, Volume 97, Issue 6, 11 June 1999, Pages 717-726 Christian E. Rocheleau, Jun Yasuda, Tae Ho Shin, Rueyling Lin, Hitoshi Sawa, Hideyuki Okano, James R. Priess, Roger J. Davis and Craig C. Mello
PDF (363 K)   External link   Abstract via Science Direct

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos Cell, Volume 90, Issue 4, 22 August 1997, Pages 707-716 Christian E. Rocheleau , William D. Downs , Rueyling Lin , Claudia Wittmann , Yanxia Bei , Yoon-Hee Cha , Mussa Ali , James R. Priess and Craig C. Mello
PDF (306 K)     External link  Abstract via Science Direct

MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos Cell, Volume 87, Issue 2, 18 October 1996, Pages 205-216 Bruce W. Draper, Craig C. Mello, Bruce Bowerman, Jeff Hardin and James R. Priess
PDF (666 K)    External link   Abstract via Science Direct

The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos Cell, Volume 74, Issue 3, 13 August 1993, Pages 443-452 Bruce Bowerman, Bruce W. Draper, Craig C. Mello and James R. Priess
PDF (3421 K)    External link   Abstract via Science Direct

The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos Cell, Volume 70, Issue 1, 10 July 1992, Pages 163-176 Craig C. Mello, Bruce W. Draper, Michael Krause, Harold Weintraub and James R. Priess
PDF (1766 K)     External link  Abstract via Science Direct

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The 2006 Nobel Prizes

Elsevier publications by the other Nobel Prize Winner in Physiology or Medicine 2006

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