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| Elsevier publications by Roger D. Kornberg | |
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The Nobel Prize in Chemistry 2006
"for
his studies of the molecular basis of eukaryotic transcription."
Eukaryotic
transcription is the process through which the genetic information encoded in
DNA is copied into messenger RNA (mRNA). The resulting strands of mRNA act as
recipes for the synthesis of proteins. The field of transcription originated
nearly 50 years ago, when the activity of an RNA polymerase-the enzyme which
produces RNA from DNA-was first measured in rats.
Early
research then turned primarily to the study of transcription in relatively
simpler prokaryotes, or bacteria. It was Nobel laureate Roger Kornberg who
unlocked the more complicated process of transcription and transcriptional
control in eukaryotic cells, whose genomes are housed within distinct nuclei.
In the 1970s, Kornberg discovered the nucleosome which is the protein complex
packaging chromosomal DNA (usually known as "Chromatin") in the nucleus of
eukaryotic cells.
He then uncovered other essential players
governing the transcription process, including "Mediator", a multi-protein
complex that relays signals from transcription factors to the transcribing
enzyme, RNA polymerase II. He later captured the first crystallographic
pictures of the dynamic transcription machinery. Those molecular -level images
revealed the growth of an mRNA strand, and further elucidated the role of key
players in the process.
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Head Module Control of Mediator Interactions Molecular
Cell, Volume 23, Issue 3, 4 August 2006, Pages 355-364 Yuichiro Takagi,
Guillermo Calero, Hirofumi Komori, Jesse A. Brown, Andreas H. Ehrensberger,
Andy Hudmon, Francisco Asturias and Roger D. Kornberg
PDF
(573 K)
Abstract
via ScienceDirect
Mediator comes of age Trends in
Biochemical Sciences, Volume 30, Issue 5, May 2005, Page 221 Roger D.
Kornberg
PDF
(45 K)
Abstract
via ScienceDirect
Mediator and the mechanism of transcriptional
activation Trends in Biochemical Sciences
, Volume 30, Issue 5, May 2005, Pages 235-239 Roger D. Kornberg
PDF
(104 K)
Abstract
via ScienceDirect
Ubiquitin Ligase Activity of TFIIH and the
Transcriptional Response to DNA Damage Molecular Cell,
Volume 18, Issue 2, 15 April 2005, Pages 237-243 Yuichiro Takagi, Claudio A.
Masuda, Wei-Hau Chang, Hirofumi Komori, Dong Wang, Tony Hunter, Claudio A.P.
Joazeiro and Roger D. Kornberg
PDF
(318 K)
Abstract
via ScienceDirect
Structural
basis of eukaryotic gene transcription FEBS Letters , Volume
579, Issue 4, 7 February 2005, Pages 899-903 Hinrich Boeger, David A.
Bushnell, Ralph Davis, Joachim Griesenbeck, Yahli Lorch, J. Seth Strattan,
Kenneth D. Westover and Roger D. Kornberg
PDF
(461 K)
Abstract
via Science Direct
Structural Basis of Transcription: Nucleotide
Selection by Rotation in the RNA Polymerase II Active Center Cell
, Volume 119, Issue 7, 29 December 2004, Page 1055 Kenneth D. Westover, David
A. Bushnell and Roger D. Kornberg
PDF
(21 K)
Abstract
via Science Direct
Structural Basis of Transcription: Nucleotide
Selection by Rotation in the RNA Polymerase II Active Center Cell
, Volume 119, Issue 4, 12 November 2004, Pages 481-489 Kenneth D. Westover,
David A. Bushnell and Roger D. Kornberg
PDF
(516 K)
Abstract
via Science Direct
Removal of Promoter Nucleosomes by Disassembly Rather
Than Sliding In Vivo Molecular Cell, Volume 14, Issue 5, 4
June 2004, Pages 667-673 Hinrich Boeger, Joachim Griesenbeck, J. Seth Strattan
and Roger D. Kornberg
PDF
(276 K)
Abstract
via Science Direct
RNA Polymerase II/TFIIF Structure and Conserved
Organization of the Initiation Complex Molecular Cell,
Volume 12, Issue 4, October 2003, Pages 1003-1013 Wen-Hsiang Chung, John L.
Craighead, Wei-Hau Chang, Chukwudi Ezeokonkwo, Avital Bareket-Samish, Roger
D. Kornberg and Francisco J. Asturias
PDF
(630 K)
Abstract
via Science Direct
Nucleosomes Unfold Completely at a Transcriptionally
Active Promoter Molecular Cell, Volume 11, Issue 6, June
2003, Pages 1587-1598 Hinrich Boeger, Joachim Griesenbeck, J. Seth Strattan
and Roger D. Kornberg
PDF
(479 K)
Abstract
via Science Direct
Electron Microscopic Analysis of the RSC Chromatin
Remodeling Complex Methods in Enzymology, Volume 376, 2003,
Pages 48-62 Francisco J. Asturias, Chukwudi Ezeokonkwo, Roger D. Kornberg and
Yahli Lorch
PDF
(509 K)
Abstract
via Science Direct
Purification of Defined Chromosomal Domains
Methods in Enzymology, Volume 375, 2003, Pages 170-178 Joachim
Griesenbeck, Hinrich Boeger, J. Seth Strattan and Roger D. Kornberg
PDF
(134 K)
Abstract
via Science Direct
Isolation and Assay of the RSC Chromatin-Remodeling
Complex from Saccharomyces cerevisiae Methods in Enzymology,
Volume 377, 2003, Pages 316-322 Yahli Lorch and Roger D. Kornberg
PDF
(104 K)
Abstract
via Science Direct
Structure of the Yeast RNA Polymerase II Holoenzyme:
Mediator Conformation and Polymerase Interaction Molecular Cell
, Volume 10, Issue 2, August 2002, Pages 409-415 Joshua A. Davis, Yuichiro
Takagi, Roger D. Kornberg and Francisco J. Asturias
PDF
(403 K)
Abstract
via Science Direct
Chromatin and transcription: where do we go from here?
Current Opinion in Genetics & Development, Volume 12, Issue 2, 1
April 2002, Pages 249-251 Roger D. Kornberg and Yahli Lorch
PDF
(59 K)
Abstract
via Science Direct
RSC Unravels the Nucleosome Molecular
Cell, Volume 7, Issue 1, 1 January 2001, Pages 89-95 Yahli Lorch, Mincheng
Zhang and Roger D. Kornberg
PDF
(237 K)
Abstract
via Science Direct
Selenomethionine Incorporation in Saccharomyces
cerevisiae RNA Polymerase II Structure, Volume 9, Issue 1,
January 2001, Pages R11-R14 David A. Bushnell, Patrick Cramer and Roger D.
Kornberg
PDF
(126 K)
Abstract
via Science Direct
Electron Crystal Structure of the Transcription
Factor and DNA Repair Complex, Core TFIIH Cell, Volume 102,
Issue 5, 1 September 2000, Pages 609-613 Wei-Hau Chang and Roger D. Kornberg
PDF
(201 K)
Abstract
via Science Direct
Defocus-gradient corrected back-projection Ultramicroscopy,
Volume 84, Issues 1-2, July 2000, Pages 57-64 Grant J. Jensen and Roger D.
Kornberg
PDF
(167 K)
Abstract
via Science Direct
Mediator–Nucleosome
Interaction Molecular Cell, Volume 6, Issue 1, July 2000,
Pages 197-201 Yahli Lorch, Jenny Beve, Claes M. Gustafsson, Lawrence C. Myers
and Roger D. Kornberg
PDF
(164 K)
Abstract
via Science Direct
Eukaryotic transcriptional control Trends
in Genetics, Volume 15, Issue 12, 1 December 1999, Pages M46-M49 Roger
D. Kornberg
PDF
(454 K)
Abstract
via Science Direct
Eukaryotic transcriptional control Trends
in Cell Biology, Volume 9, Issue 12, 1 December 1999, Pages M46-M49 Roger
D. Kornberg
PDF
(454 K)
Abstract
via Science Direct
Eukaryotic transcriptional control Trends
in Biochemical Sciences, Volume 24, Issue 12, 1 December 1999, Pages
M46-M49 Roger D. Kornberg
PDF
(454 K)
Abstract
via Science Direct
Two Functionally Distinct Forms of the RSC
Nucleosome-Remodeling Complex, Containing Essential AT Hook, BAH, and
Bromodomains Molecular Cell, Volume 4, Issue 5, November
1999, Pages 715-723 Bradley R. Cairns, Alisha Schlichter, Hediye
Erdjument-Bromage, Paul Tempst, Roger D. Kornberg and Fred Winston
PDF
(454 K)
Abstract
via Science Direct
Electron Crystal Structure of an RNA Polymerase II
Transcription Elongation Complex Cell, Volume 98, Issue 6,
17 September 1999, Pages 791-798 Claudia L. Poglitsch, Gavin D. Meredith,
Averell L. Gnatt, Grant J. Jensen, Wei-hau Chang, Jianhua Fu and Roger D.
Kornberg
PDF
(227 K)
Abstract
via Science Direct
Yeast RNA Polymerase II at 5 Å Resolution
Cell, Volume 98, Issue 6, 17 September 1999, Pages 799-810 Jianhua Fu,
Averell L. Gnatt, David A. Bushnell, Grant J. Jensen, Nancy E. Thompson,
Richard R. Burgess, Peter R. David and Roger D. Kornberg
PDF
(1167 K)
Abstract
via Science Direct
Twenty-Five Years of the Nucleosome, Fundamental
Particle of the Eukaryote Chromosome Cell, Volume 98, Issue
3, 6 August 1999, Pages 285-294 Roger D. Kornberg and Yahli Lorch
PDF
(130 K)
Abstract
via Science Direct
Chromatin-modifying and -remodeling complexes
Current Opinion in Genetics & Development, Volume 9, Issue 2, April
1999, Pages 148-151 Roger D Kornberg and Yahli Lorch
PDF
(441 K)
Abstract
via Science Direct
Histone Octamer Transfer by a Chromatin-Remodeling
Complex Cell, Volume 96, Issue 3, 5 February 1999, Pages
389-392 Yahli Lorch, Mincheng Zhang and Roger D. Kornberg
PDF
(71 K)
Abstract
via Science Direct
Two Actin-Related Proteins Are Shared Functional
Components of the Chromatin-Remodeling Complexes RSC and SWI/SNF Molecular
Cell, Volume 2, Issue 5, November 1998, Pages 639-651 Bradley R. Cairns,
Hediye Erdjument-Bromage, Paul Tempst, Fred Winston and Roger D. Kornberg
PDF
(522 K)
Abstract
via Science Direct
Repeated tertiary fold of RNA polymerase II and
implications for DNA binding Journal of Molecular Biology,
Volume 280, Issue 3, 17 July 1998, Pages 317-322 Jianhua Fu, Mark Gerstein,
Peter R. David, Averell L. Gnatt, David A. Bushnell, Aled M. Edwards and Roger
D. Kornberg
PDF
(294 K)
Abstract
via Science Direct
Activated RSC–Nucleosome Complex and Persistently
Altered Form of the Nucleosome Cell, Volume 94, Issue 1, 10
July 1998, Pages 29-34 Yahli Lorch, Bradley R. Cairns, Mincheng Zhang and Roger
D. Kornberg
PDF
(190 K)
Abstract
via Science Direct
Electron crystallography of yeast RNA polymerase II
preserved in vitreous ice Ultramicroscopy, Volume 70, Issue
3, January 1998, Pages 133-143 Francisco J. Asturias, Weihau Chang, Yang Li
and Roger D. Kornberg
PDF
(985 K)
Abstract
via Science Direct
Two conformations of RNA polymerase II revealed by
electron crystallography Journal of Molecular Biology,
Volume 272, Issue 4, 3 October 1997, Pages 536-540 Francisco J. Asturias,
Gavin D. Meredith, Claudia L. Poglitsch and Roger D. Kornberg
PDF
(306 K)
Abstract
via Science Direct
Yeast RNA Polymerase II Transcription Reconstituted
with Purified Proteins Methods, Volume 12, Issue 3, July
1997, Pages 212-216 Lawrence C. Myers, Kerstin Leuther, David A. Bushnell,
Claes M. Gustafsson and Roger D. Kornberg
PDF
(107 K)
Abstract
via Science Direct
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[11] Two-dimensional protein crystals in aid of
three-dimensional protein crystal growth Methods in Enzymology
, Volume 276, 1997, Pages 166-171 Aled M. Edwards, Seth A. Darst, Sally A.
Hemming, Francisco J. Asturias, Peter R. David and Roger D. Kornberg
PDF
(324 K)
Abstract
via Science Direct
RSC, an Essential, Abundant Chromatin-Remodeling
Complex Cell, Volume 87, Issue 7, 27 December 1996, Pages
1249-1260 Bradley R. Cairns, Yahli Lorch, Yang Li, Mincheng Zhang, Lynne
Lacomis, Hediye Erdjument-Bromage, Paul Tempst, Jian Du, Brehon Laurent and Roger
D. Kornberg
PDF
(3235 K)
Abstract
via Science Direct
RNA polymerase II transcription control Trends
in Biochemical Sciences, Volume 21, Issue 9, September 1996, Pages 325-326 Roger
D. Kornberg
PDF
(330 K)
Abstract
via Science Direct
Two-Dimensional Crystallography of TFIIB– and IIE–RNA
Polymerase II Complexes: Implications for Start Site Selection and Initiation
Complex Formation Cell, Volume 85, Issue 5, 31 May 1996,
Pages 773-779 Kerstin K. Leuther, David A. Bushnell and Roger D. Kornberg
PDF
(262 K)
Abstract
via Science Direct
The C-terminal Domain Revealed in the Structure of
RNA Polymerase II Journal of Molecular Biology, Volume 258,
Issue 3, 10 May 1996, Pages 413-419 Gavin D. Meredith, Wei-Hau Chang, Yang Li,
David A. Bushnell, Seth A. Darst and Roger D. Kornberg
PDF
(284 K)
Abstract
via Science Direct
[15] Yeast RNA polymerase II holoenzyme Methods
in Enzymology, Volume 273, 1996, Pages 172-176 Yang Li , Stefan Bjorklund
, Young-Joon Kim and Roger D. Kornberg
PDF
(357 K)
Abstract
via Science Direct
The Mechanism of Protein Crystal Growth from Lipid
Layers Journal of Molecular Biology, Volume 246, Issue 2, 17
February 1995, Pages 308-316 Sally A. Hemming, Alexey Bochkarev, Seth A.
Darst, Roger D. Kornberg, Paul Ala, Daniel S. C. Yang and Aled M.
Edwards
PDF
(2507 K)
Abstract
via Science Direct
Different forms of TFIIH for transcription and DNA
repair: Holo-TFIIH and a nucleotide excision repairosome Cell
, Volume 80, Issue 1, 13 January 1995, Pages 21-28 Jesper Q. Svejstrup,
Zhigang Wang, William J. Feave, Xiahua Wu, David A. Bushnell, Thomas F.
Donahue, Errol C. Friedberg and Roger D. Kornberg
PDF
(1300 K)
Abstract
via Science Direct
A Novel Method for Transfer of Two-Dimensional
Crystals from the Air/Water Interfacé to Specimen Grids : EM Sample
Preparation/Lipid-Layer Crystallization Journal of Structural
Biology, Volume 114, Issue 1, January 1995, Pages 60-66 Francisco J.
Asturias and Roger D. Kornberg
PDF
(992 K)
Abstract
via Science Direct
Interplay between chromatin structure and
transcription Current Opinion in Cell Biology, Volume 7,
Issue 3, 1995, Pages 371-375 Roger D Kornberg and Yahli Lorch
PDF
(590 K)
Abstract
via Science Direct
Relationship of CDK-activating kinase and RNA
polymerase II CTD kinase TFIIH/TFIIK Cell, Volume 79, Issue
6, 16 December 1994, Pages 1103-1109 William J. Feaver , Jesper Q. Svejstrup ,
N. Lynn Henry and Roger D. Kornberg
PDF
(957 K)
Abstract
via Science Direct
A multiprotein mediator of transcriptional activation
and its interaction with the C-terminal repeat domain of RNA polymerase II
Cell, Volume 77, Issue 4, 20 May 1994, Pages 599-608 Young-Joon Kim,
Stefan Björklund, Yang Li, Michael H. Sayre and Roger D. Kornberg
PDF
(3698 K)
Abstract
via Science Direct
Dual roles of a multiprotein complex from S.
cerevisiae in transcription and DNA repair Cell, Volume 75,
Issue 7, 31 December 1993, Pages 1379-1387 William J. Feaver, Jesper Q.
Svejstrup, Lee Bardwell, A. Jane Bardwell, Stephen Buratowski, Keith D.
Gulyas, Thomas F. Donahue, Errol C. Friedberg and Roger D. Kornberg
PDF
(2106 K)
Abstract
via Science Direct
CTD kinase associated with yeast RNA polymerase II
initiation factor b Cell, Volume 67, Issue 6, 20 December
1991, Pages 1223-1230 William J. Feaver, Opher Gileadi, Yang Li and Roger
D. Kornberg
PDF
(3322 K)
Abstract
via Science Direct
Irresistible force meets immovable object:
Transcription and the nucleosome Cell, Volume 67, Issue 5,
29 November 1991, Pages 833-836 Roger D. Kornberg and Yahli Lorch
PDF
(556 K)
Abstract
via Science Direct
Two-dimensional and epitaxial crystallization of a
mutant form of yeast RNA polymerase II Journal of Molecular
Biology, Volume 221, Issue 1, 5 September 1991, Pages 347-357 Seth A.
Darst, Elizabeth W. Kubalek, Aled M. Edwards and Roger D. Kornberg
PDF
(1562 K)
Abstract
via Science Direct
Two-dimensional crystals of proteins on lipid layers
Current Opinion in Structural Biology, Volume 1, Issue 4, August 1991,
Pages 642-646 Roger D. Kornberg and Seth A. Darst
PDF
(1562 K)
Abstract
via Science Direct
Three-dimensional structure of yeast RNA polymerase
II at 16 Å resolution Cell, Volume 66, Issue 1, 12 July
1991, Pages 121-128 Seth A. Darst, Aled M. Edwards, Elizabeth W. Kubalek and Roger
D. Kornberg
PDF
(9692 K)
Abstract
via Science Direct
Improved transfer of two-dimensional crystals from
the air/water interface to specimen support grids for high-resolution analysis
by electron microscopy Ultramicroscopy, Volume 35, Issues
3-4, June 1991, Pages 295-304 Elizabeth W. Kubalek, Roger D. Kornberg
and Seth A. Darst
PDF
(979 K)
Abstract
via Science Direct
[38] RNA polymerase II transcription in vitro
Methods in Enzymology, Volume 194, 1991, Pages 545-550 Neal F. Lue,
Peter M. Flanagan, Raymond J. Kelleher, III, Aled M. Edwards and Roger D.
Kornberg
PDF
(757 K)
Abstract
via Science Direct
Structural study of the yeast RNA polymerase A:
Electron microscopy of lipid-bound molecules and two-dimensional crystals
Journal of Molecular Biology, Volume 216, Issue 2, 20 November 1990,
Pages 353-362 Patrick Schultz, Hervé Célia, Michel Riva, Seth A. Darst, Pierre
Colin, Roger D. Kornberg, André Sentenac and Pierre Oudet
PDF
(3914 K)
Abstract
via Science Direct
A novel mediator between activator proteins and the
RNA polymerase II transcription apparatus Cell, Volume 61,
Issue 7, 29 June 1990, Pages 1209-1215 Raymond J. Kelleher, III , Peter M.
Flanagan and Roger D. Kornberg
PDF
(1005 K)
Abstract
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Purification and characterization of
polyadenylate-binding protein Methods in Enzymology, Volume
181, 1990, Pages 332-352 Alan B. Sachs and Roger D. Kornberg
PDF
(2764 K)
Abstract
via Science Direct
[1] Preparation of nucleosomes and chromatin
Methods in Enzymology, Volume 170, 1989, Pages 3-14 Roger D. Kornberg
, Jan W. Lapointe and Yahli Lorch
PDF
(2436 K)
Abstract
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Preface Methods in Enzymology,
Volume 170, 1989, Pages xiii-xiv Paul M. Wassarman and Roger D. Kornberg
PDF
(79 K)
Abstract
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On the displacement of histones from DNA by
transcription Cell, Volume 55, Issue 5, 2 December 1988,
Pages 743-744 Yahli Lorch, Janice W. LaPointe and Roger D. Kornberg
PDF
(357 K)
Abstract
via Science Direct
Statistical positioning of nucleosomes by specific
protein-binding to an upstream activating sequence in yeast Journal
of Molecular Biology, Volume 204, Issue 1, 5 November 1988, Pages 109-127
Martha J. Fedor, Neal F. Lue and Roger D. Kornberg
PDF
(11826 K)
Abstract
via Science Direct
Two-dimensional crystals of Escherichia coli RNA
polymerase holoenzyme on positively charged lipid layers Journal
of Molecular Biology, Volume 203, Issue 1, 5 September 1988, Pages 269-273
Seth A. Darst, Hans O. Ribi, Dan W. Pierce and Roger D. Kornberg
PDF
(2884 K)
Abstract
via Science Direct
Nucleosomes inhibit the initiation of transcription
but allow chain elongation with the displacement of histones Cell
, Volume 49, Issue 2, 24 April 1987, Pages 203-210 Yahli Lorch, Janice W.
LaPointe and Roger D. Kornberg
PDF
(3511 K)
Abstract
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A single gene from yeast for both nuclear and
cytoplasmic polyadenylate-binding proteins: Domain structure and expression
Cell, Volume 45, Issue 6, 20 June 1986, Pages 827-835 Alan B. Sachs,
Martha W. Bond and Roger D. Kornberg
PDF
(1687 K)
Abstract
via Science Direct
A region flanking the GAL7 gene and a binding site
for GAL4 protein as upstream activating sequences in yeast Journal
of Molecular Biology, Volume 186, Issue 4, 20 December 1985, Pages 821-824
Yahli Lorch and Roger D. Kornberg
PDF
(1797 K)
Abstract
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Variable center to center distance of nucleosomes in
chromatin Journal of Molecular Biology, Volume 154, Issue 3,
January 1982, Pages 515-523 Ariel Prunell and Roger D. Kornberg
PDF
(1180 K)
Abstract
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Action of micrococcal nuclease on chromatin and the
location of histone H1 Journal of Molecular Biology, Volume
109, Issue 3, 25 January 1977, Pages 393-404 Markus Noll and Roger D.
Kornberg
PDF
(4389 K)
Abstract
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Cleavable
cross-links in the analysis of histone—histone associations FEBS
Letters, Volume 58, Issues 1-2, 15 October 1975, Pages 353-358 Jean O.
Thomas, Roger D. Kornberg
PDF
(520 K)
Abstract
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On the heterogeneity of the deoxyribonucleic acid
associated with crystalline yeast cytochrome b2 Biochimica
et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, Volume
108, Issue 2, 11 October 1965, Pages 243-248 J. F. Jackson, Roger D.
Kornberg, Paul Berg, U. L. Rajbhandary, A. Stuart, H. G. Khorana and
Arthur Kornberg
PDF
(375 K)
Abstract
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Competition between RNA polymerase and DNA polymerase
for the DNA template Biochemical and Biophysical Research
Communications, Volume 18, Issues 5-6, 12 March 1965, Pages 932-942 Paul
Berg, Roger D. Kornberg, Harriet Fancher and Marianne Dieckmann
PDF
(564 K)
Abstract
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