Elsevier publications by Andrew Z. Fire
The Nobel Prize in Physiology or Medicine 2006

External link  "for their discovery of RNA interference - gene silencing by double-stranded RNA"

The genetic instructions contained within the genome are copied into strands of messenger RNA (mRNA), which subsequently serve as recipes for proteins. First discovered by Nobel laureates Andrew Fire and Craig Mello in 1998, RNA interference (RNAi) is a mechanism for controlling the flow of genetic information through the selective degradation of mRNA.

When particular mRNA molecules are lost through RNAi, no protein of that type is produced and the gene encoding that protein is effectively silenced. Fire and Mello's breakthrough came when they found that double-stranded RNA, made up of complementary "sense" and "anti-sense" strands, silenced genes with a matching code in the worm Caenorhabditis elegans.

Researchers have gone on to study the RNAi machinery and how it is regulated, and have found that the process plays important roles in controlling gene activity and defending against viruses. RNAi is now an important research tool for unraveling the function of genes. Scientists are also investigating RNAi-based drugs for a variety of diseases, ranging from cardiovascular disease to cancer.

Cyclin D involvement demarcates a late transition in C. elegans embryogenesis Developmental Biology, Volume 279, Issue 1, 1 March 2005, Pages 244-251 Judith Yanowitz and Andrew Fire
PDF (556 K)    External link  Abstract via ScienceDirect

UNC-39, the C. elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation Developmental Biology, Volume 272, Issue 2, 15 August 2004, Pages 389-402 Judith L. Yanowitz, M. Afaq Shakir, Edward Hedgecock, Harald Hutter, Andrew Z. Fire and Erik A. Lundquist
PDF (992 K)    External link  Abstract via ScienceDirect

Loss of the Putative RNA-Directed RNA Polymerase RRF-3 Makes C. elegans Hypersensitive to RNAi  Current Biology, Volume 12, Issue 15, 6 August 2002, Pages 1317-1319 Femke Simmer, Marcel Tijsterman, Susan Parrish, Sandhya P. Koushika, Michael L. Nonet, Andrew Fire, Julie Ahringer and Ronald H. A. Plasterk
PDF (145 K)    External link  Abstract via ScienceDirect

On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing Cell, Volume 107, Issue 4, 16 November 2001, Pages 465-476 Titia Sijen, Jamie Fleenor, Femke Simmer, Karen L. Thijssen, Susan Parrish, Lisa Timmons, Ronald H. A. Plasterk and Andrew Fire
PDF (1341 K)    External link  Abstract via ScienceDirect

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
Cell, Volume 106, Issue 1, 13 July 2001, Pages 23-34 Alla Grishok, Amy E. Pasquinelli, Darryl Conte, Na Li, Susan Parrish, Ilho Ha, David L. Baillie, Andrew Fire, Gary Ruvkun and Craig C. Mello
PDF (466 K)    External link  Abstract via Science Direct

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans Gene, Volume 263, Issues 1-2, 24 January 2001, Pages 103-112 Lisa Timmons, Donald L. Court and Andrew Fire
PDF (728 K)    External link  Abstract via Science Direct

The MADS-Box Factor CeMEF2 Is Not Essential for Caenorhabditis elegans Myogenesis and Development  Developmental Biology, Volume 223, Issue 2, 15 July 2000, Pages 431-440 Daryl Dichoso, Thomas Brodigan, Kyu Yeong Chwoe, Jin Sook Lee, Reymond Llacer, Morgan Park, Ann K. Corsi, Stephen A. Kostas, Andrew Fire, Joohong Ahnn and Michael Krause
PDF (291 K)     External link  Abstract via Science Direct

dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference Gene, Volume 252, Issues 1-2, 11 July 2000, Pages 95-105 Natasha J. Caplen, Jamie Fleenor, Andrew Fire and Richard A. Morgan
PDF (443 K)    External link  Abstract via Science Direct

Functional Anatomy of a dsRNA Trigger: Differential Requirement for the Two Trigger Strands in RNA Interference Molecular Cell, Volume 6, Issue 5, November 2000, Pages 1077-1087 Susan Parrish, Jamie Fleenor, SiQun Xu, Craig Mello and Andrew Fire
PDF (1239 K)    External link  Abstract via Science Direct

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans Cell, Volume 99, Issue 2, 15 October 1999, Pages 123-132 Hiroaki Tabara, Madathia Sarkissian, William G. Kelly, Jamie Fleenor, Alla Grishok, Lisa Timmons, Andrew Fire and Craig C. Mello
PDF (264 K)    External link  Abstract via Science Direct

RNA-triggered gene silencing Trends in Genetics, Volume 15, Issue 9, 1 September 1999, Pages 358-363 Andrew Fire
PDF (222 K)    External link  Abstract via Science Direct

Evolutionary Conservation of MyoD Function and Differential Utilization of E Proteins Developmental Biology, Volume 208, Issue 2, 15 April 1999, Pages 465-472 Jian-Min Zhang, Lihsia Chen, Michael Krause, Andrew Fire and Bruce M. Paterson
PDF (183 K)     External link  Abstract via Science Direct

Reply Trends in Genetics, Volume 15, Issue 1, 1 January 1999, Page 12 Andrew Fire and Mary Montgomery
PDF (74 K)   External link   Abstract via Science Direct

Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression Trends in Genetics, Volume 14, Issue 7, 1 July 1998, Pages 255-258 Mary K. Montgomery and Andrew Fire
PDF (158 K)     External link  Abstract via Science Direct

Elements Regulating Cell- and Stage-Specific Expression of the C. elegans MyoD Family Homolog hlh-1 Developmental Biology, Volume 166, Issue 1, November 1994, Pages 133-148 Michael Krause, Susan White Harrison, Si-Qun Xu, Lihsia Chen and Andrew Fire
PDF (1272 K)    External link   Abstract via Science Direct

Histochemical techniques for locating Escherichia coli β-galactosidase activity in transgenic organisms Genetic Analysis: Biomolecular Engineering, Volume 9, Issues 5-6, October-December 1992, Pages 151-158 Andrew Fire
PDF (776 K)    External link   Abstract via Science Direct

CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis Cell, Volume 63, Issue 5, 30 November 1990, Pages 907-919 Michael Krause, Andrew Fire, Susan White Harrison, James Priess and Harold Weintraub
PDF (5901 K)     External link  Abstract via Science Direct

A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans Gene, Volume 93, Issue 2, 1990, Pages 189-190 Andrew Fire, Susan White Harrison and Dennis Dixon
PDF (1401 K)     External link  Abstract via Science Direct

[35] In Vitro transcription: Whole-cell extract Methods in Enzymology, Volume 101, 1983, Pages 568-582 James L. Manley, Andrew Fire, Mark Samuels and Phillip A. Sharp
PDF (934 K)   External link  Abstract via Science Direct
External link 
Inhibition of transcription factor activity by poliovirus
Cell, Volume 27, Issue 3, Part 2, December 1981, Pages 555-561 Nigel Crawford, Andrew Fire, Mark Samuels, Phillip A. Sharp and David Baltimore
PDF (2004 K)    External link  Abstract via Science Direct

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