CAS Science Spotlight is a free web service that identifies the most requested research publications as reflected by requests for full text via their online services.  Additionally, the most cited chemistry-related research publications as reflected by the more than 100 million citations found in the journals, patents, conference proceedings and other sources covered by CAS are identified.

Elsevier is proud to be the publishers of # 1 and # 2 most requested chemistry papers in 2005*, as recognised by CAS Science Spotlight.
You are invited to access these and other highly-valued articles by clicking on the paper title.

# 1
MOST REQUESTED 'CHEMISTRY AND RELATED SCIENCE' PAPER ON CAS
The following Elsevier article was the #2 most requested 'chemistry and related science' article for 1Q05 and the #1 most requested for 2Q05 and 3Q05:
Title: A useful bicyclic topological decapeptide template for solution-phase combinatorial synthesis of tetrapodal libraries
Published: Tetrahedron Letters,  pp7261-7263, vol.42:41, (2001)
If you do not have access to this article on ScienceDirect, click here

#2
MOST REQUESTED 'CHEMISTRY AND RELATED SCIENCE' PAPER ON CAS
The following Elsevier article was the #1 most requested 'chemistry and related science' article for 4Q04 and 1Q05 and #2 most requested for 2Q05 and 3Q05:
Title: Convenient synthesis of human calcitonin and its methionine sulfoxide derivative
Published: Bioorganic & Medicinal Chemistry Letters, pp2237-2240, vol.12:16 (2002)
If you do not have access to this article on ScienceDirect, click here

* Tet. Lett. article, #2, #1, #1 most requested for first three quarters of 2005
  BMCL article, #1, #2, #2 most requested for first three quarters of 2005
  Final quarter and cumulative year data not yet released by CAS.

OTHER ELSEVIER 'TOP FIVE' PAPERS AS IDENTIFIED BY CAS SCIENCE SPOTLIGHT

#1 MOST REQUESTED 'CHEMISTRY AND RELATED SCIENCE' PAPER ON CAS
The following Elsevier article was the #1 most requested chemistry article for 2002 and 2003:
Title:   Glucan synthesis. Part VI. Total synthesis of cyclomaltohexaose
Published: Carbohydrate Research, pp277-296, vol.164 (1987)
If you do not have access to this article on ScienceDirect, click here

#1 MOST CITED ‘CHEMISTRY AND RELATED SCIENCE’ PAPER ON CAS
The following Elsevier article was the #1 most cited ‘chemistry and related science’ article for 2004 and 2003 and the #2 most cited for 1999, 2000, 2001 and 2002:
Title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Published: Analytical Biochemistry, pp248-254, vol.72:1-2 (1976)
To access this article, click here

#1 MOST CITED 'MATERIALS SCIENCE' PAPER ON CAS
The following Elsevier article was the #1 most cited  'materials science' article for 2004 and 2003:
Title:  Efficiency of ab-initio total energy calculations for metals and semiconductors using a plane-wave basis set
Published: Computational Materials Science, pp15-50, vol.6:1 (1996)
If you do not have access to this article on ScienceDirect, click here

#1 MOST CITED ‘MEDICAL SCIENCES’ PAPER ON CAS
The following Elsevier article was the #1 most cited  'medical sciences' article for 2004 and the #2 most cited for 2003:
Title: The hallmarks of cancer
Published: Cell, pp57-70, vol.100:1 (2000)
If you do not have access to this article via the above link, click here

#3 MOST REQUESTED 'CHEMISTRY AND RELATED SCIENCE' PAPER ON CAS
The following Elsevier article was the #3 most requested chemistry article for 2003:
Title: Recent applications of the Suzuki-Miyaura cross-coupling reaction in organic synthesis
Published: Tetrahedron, pp9633-9695, vol.58:48 (2002)
If you do not have access to this article on ScienceDirect, click here

# 5 MOST REQUESTED 'CHEMISTRY AND RELATED SCIENCE' PAPER ON CAS
The following Elsevier article was the #2 most requested 'chemistry and related science' article for 4Q04 and the #5 most requested for 1Q05:
Title: Olefin metathesis
Published: Tetrahedron, pp7117-7140, vol.60: 34, (2004)
If you do not have access to this article on ScienceDirect, click here

 
ELSEVIER 'TOP TEN' PAPERS AS IDENTIFIED BY CAS SCIENCE SPOTLIGHT

NEW
Title: Regioselective cross-coupling reactions of multiple halogenated nitrogen-, oxygen-, and sulfur-containing heterocycles
Published: Tetrahedron, pp2245-2267, vol. 61:9 (2005)
If you do not have access to this article via the above link, click  here
A 'top ten' most requested 'chemistry and related science' article for 2Q05

NEW
Title: Bulk nanostructured materials from severe plastic deformation
Published: Progress in Materials Science, pp103-189, vol. 45:2 (2000)
If you do not have access to this article via the above link, click  here
A 'top ten' most cited 'materials science' article for 2004

Title: The growing impact of click chemistry on drug discovery
Published: Drug Discovery Today, pp1128-1137, vol. 8:24 (2003)
If you do not have access to this article via the above link, click here
A 'top ten' most requested 'chemistry and related science' article for 2004

Title: Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
Published: Cell, pp353-364, vol. 86:3 (1996)
If you do not have access to this article via the above link, click here
A 'top ten' most cited 'medical sciences' article for 2003

Title: Phospha-palladacycles and N-heterocyclic carbene palladium complexes: efficient catalysts for CC-coupling reactions
Published: Journal of Organometallic Chemistry, pp229-248, vol. 687:2 (2003)
If you do not have access to this article via the above link, click here
A 'top ten' most requested 'chemistry and related science' article for 2Q04 and 3Q04

Title: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Published: Analytical Biochemistry, pp156-159, vol.162:1 (1987)
To access this article, click here
A ‘top ten’ most cited ‘chemistry and related science’ article for 1999, 2000, 2001, 2002,  2003 and 2004

Title:  Processing of x-ray diffraction data collected in oscillation mode
Published: Methods in Enzymology, pp307-326, vol.276, Macomolecular Crystallography, Part A (1997)
If you do not have access to this article on ScienceDirect, click here
A ‘top ten’ most cited ‘chemistry and related science’ article for 2001, 2002, 2003 and  2004

Title:   Basic local alignment search tool
Published: Journal of Molecular Biology, pp403-410, vol.215:3 (1990)
If you do not have access to this article on ScienceDirect, click here
A ‘top ten’ most cited ‘chemistry and related science’ article for 1999, 2000, 2001, 2002, 2003 and 2004

Title: Stabilization of metallic supercooled liquid and bulk amorphous alloys
Published: Acta Materialia, pp279-306, vol. 48:1 (2000)
If you do not have access to this article via the above link, click here
A 'top ten' most cited 'materials science' article for 2003 and 2004

Title:  The nuclear receptor superfamily: The second decade
Published: Cell, pp835-839, vol.83:6 (1995)
If you do not have access to this article via the above link, click here
A ‘top ten’ most cited ‘medical sciences’ article for 2000, 2001 and 2002

Title:   Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm
Published: Cell, pp301-314, vol.76:2 (1994)
If you do not have access to this article via the above link, click here
A ‘top ten’ most cited ‘medical sciences’ article for 1999, 2000, 2001 and 2002

Title:   Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995-1998
Published: Journal of Organometallic Chemistry, pp147-168, vol.576:1-2 (1999)
If you do not have access to this article on ScienceDirect, click here
A ‘top ten’ most requested 'chemistry and related science' article for Q2 2002

Title:   Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Published: Cell, pp231-241, vol.91:2  (1997)
If you do not have access to this article via the above link, click here
A ‘top ten’ most cited ‘medical sciences’ article for 2001

Title:   p53, The cellular gatekeeper for growth and division
Published: Cell, pp323-331, vol.88:3 (1997)
If you do not have access to this article via the above link, click here
A ‘top ten’ most cited chemistry article for 1999 and 2000

Title: A simple method for displaying the hydropathic character of a protein
Published: Journal of Molecular Biology, pp105-132, vol.157:1 (1982)|
If you do not have access to this article via the above link, click here
A ‘top ten’ most cited chemistry article for 1999, 2000 and 2001

 
ELSEVIER 'TOP TEN' PAPER CURRENTLY BEING SOURCED

Title: The Protein Data Bank: a computer-based archival file for macromolecular structures
Published: Journal of Molecular Biology, pp535-542, vol.112:3 (1977)
A ‘top ten’ most cited chemistry article for 1999