BBA - Proteins and Proteomics - Inhibitors of Protein Kinases
BBA - Proteins and Proteomics Inhibitors of Protein Kinases Edited by David Shugar
Volume 1804, Issue 3, Pages 427-652 (March 2010)
This special issue of BBA (Proteins and Proteomics) comprises the extended texts of most of the invited lectures, largely in the form of overviews of the respective fields, presented at the 6th International Conference on Inhibitors of Protein Kinases (IPK'2009), and including Insights into Protein Kinases, held in Warsaw, Poland, June 26–July 1, 2009.
Detailed abstracts of invited lectures, and accepted posters (some of which were selected for short oral presentation) have been published in a special issue of the journal Acta Biochim Polon 56 [Suppl. 1, 2009], available on line.
Proceedings of the 1st and 2nd IPKs (IPK'1998 and IPK'2001) appeared in special issues of Pharmacology and Therapeutics [82 (2–3) 1999 and 99 (2–3) 2001, respectively]. Those of the 3rd (IPK'2003), 4th (IPK'2005) and 5th (IPK'2007) were published in special issues of BBA (Proteins and Proteomics) 1697 (1–2), 2004; 1754 (1–2), 2005; and 1784 (1) 2008, respectively.
David Shugar
During the course of graduate studies at the Faculty of Physics, McGill University, Montreal, 1937–1940, David Shugar assisted the University Medical Faculty in the construction and application of an ultracentifuge to studies of proteins. Although he graduated with a Ph. D. in physics, the foregoing inspired him to enter the field of Biophysics. In 1948–1950 he was at the Pasteur Institute and the Sorbonne in Paris, and in 1950–1952 at the laboratory of Jean Brachet, University of Brussels, where he initiated extensive studies on the properties of nucleic acid constituents and their analogues, including tautomerism, and relevance to mutagenesis, subsequently extended to polynucleotides, and photochemistry of proteins and nucleic acids. In 1952 he was invited to Warsaw, where he participated in organization of the Institute of Biochemistry and Biophysics, Polish Academy of Sciences, and then, at the invitation of the University, set up a Division of Biophysics in the Faculty of Physics. During this period he was also a visiting professor at various centres such as Universite Laval (Quebec), National Research Council (Ottawa), and Universite Ghent (Belgium). Current research interests include: fluorescent probes for studies on biopolymer folding and function, enzyme kinetics and mechanisms; development of nucleoside analogues as antiviral agents; substrates/inhibitors of nucleoside and protein kinases; phosphate donors in kinase reactions; purine and pyrimidine nucleoside phosphorylases; halogen bonding in biological systems.
