Regulatory RNA elements play pivotal roles in many key processes of the cell, such as metabolite sensing, viral and cellular gene expression, development and differentiation, and pathogen-host antagonism. Some regulatory RNA molecules perform their function in a sequence-specific way, whereas others depend as well on specific secondary and/or tertiary structural features to carry out their regulatory tasks in the cell. In recent years, a rapidly increasing number of X-ray crystal and NMR structures of these regulatory RNAs have become available, allowing us to assemble an updated review of their mechanisms of action with a structural emphasis. >> Read rest of preface
Professor Michael James FRS, FRS(C), D.Phil. (Oxon.)
Dr. James is a University Distinguished Professor in the Biochemistry Department, University of Alberta in Edmonton, Alberta, Canada. He is one of the founding members of the longstanding, celebrated MRC (now CIHR) Group in Protein Structure and Function at the University of Alberta. Dr. James was elected a Fellow of the Royal Society of London in 1989 and a Fellow of the Royal Society of Canada in 1985. He earned his doctorate from Oxford University where he studied under the guidance of the late Nobel Laureate Professor Dorothy Hodgkin, O.M., F.R.S. Dr. James is a structural biologist and uses macromolecular X-ray crystallography as his primary research tool. His major areas of research interest are currently proteolytic enzymes and their protein inhibitors, glycolytic hydrolases and the enzymic mechanisms of carbohydrate hydrolysis, RNA dependent RNA polymerases from viruses and the development of antiviral agents. In addition, Dr. James' group is involved in a Structural Genomics Consortium on Myobacterium tuberculosis.
Dr. Jiang Yin, Ph.D.
Dr. Jiang Yin received his Ph.D. in molecular and cell biology from State University of New York, Stony Brook in 2002. During his doctoral training, he studied cis-acting RNA elements involved in the initiation of picornaviral RNA genome replication. In 2004, Dr. Yin joined Prof. Michael James's group at the University of Alberta as a postdoctoral fellow. His research topics range from viral RNA binding proteins to key enzymes involved in bacterial cell wall biosynthesis in Mycobacterium tuberculosis.
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