BBA - Molecular and Cell Biology of Lipids Phospholipase - D
BBA - Molecular and Cell Biology of Lipids Phospholipase D Edited by S. Cockcroft and M. Frohman
Volume 1791, Issue 9, Pages 837-974 (September 2009)
Phospholipase D catalyses the hydrolysis of one of the most abundant phospholipids in the cells, phosphatidylcholine, to generate phosphatidic acid and choline. The presence of phospholipase D activity was first described in plants in 1947 [1] and subsequently in mammalian cells in 1979 [2]. In the nineties, phospholipase Ds were cloned from a variety of organisms including plants, yeast and mammals and the proteins that regulate phospholipase D activity were identified. In 1999, a Special issue of BBA devoted to phospholipase D edited by Dr. Larry Daniel summarised much of that development [3].
Shamshad Cockcroft is a professor of cell physiology in the Department of Neuroscience, Physiology and Pharmacology at University College London, UK. She did her Ph.D at the University of Birmingham, UK, and moved to UCL in 1977. Her broad area of work is on lipid signalling and membrane traffic and she has worked on the regulation of phospholipase D and its involvement in membrane traffic since 1984.
Michael Frohman is a professor and chair of Pharmacological Sciences at Stony Brook University in New York. He performed his M.D. and Ph.D. at the University of Pennsylvania and has been at SBU since 1992. Ever since a serendipitous entry into the phospholipase D field in 1995, his laboratory has pursued phospholipase D topics related to its molecular, cell biological and physiological function.
