BBA - Biomembranes

BBA - Biomembranes

BBA - Biomembranes
External linkAdenosine Receptors
Edited by Francisco Ciruela
Volume 1808, Issue 5, Pages 1231-1434 (May 2011)

The present issue of Biochimica et Biophysica Acta—Biomembranes is designed to summarize the main aspects of the state of the art of adenosine receptors (ARs). Thus, using ARs as a paradigm of G protein-coupled receptors (GPCRs), it is intended to provide to the reader a clear picture of how these receptors, by interacting with their surrounding milieu, mediate adenosine function.

 

Yuval Shaked

Francisco Ciruela graduated in Biology at the University of Barcelona. He performed his Ph.D. (1995) at the Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona under the supervision of Prof. E.I. Canela and Dra. J. Mallol. Throughout this period he focused on the study of the mechanisms by which adenosine regulates cell functioning through adenosine receptors. Interestingly, he described the existence of adenosine A1 receptor homodimers, a pioneering piece of work that contributed to the discovery of GPCR oligomerization. He completed a post-doctoral stage first at the MRC Anatomical Neuropharmacology Unit, University of Oxford (1996–1999) with an EMBO Long Term Fellowship, and then at the Department of Pharmacology, University of Oxford (1999–2000) as a Reader in Pharmacology. In early 2000 he enrolled back to the University of Barcelona as a Ramón y Cajal researcher. During this period he focused on the study of GPCRs oligomerization and developed several fluorescence-based methods for the analysis of receptor oligomerization. In December 2007 he joined the Department of Pathology and Experimental Therapeutics at the University of Barcelona as an Associate Professor of Pharmacology; there he established the Laboratory of Neuropharmacology and Pain. Currently, his research work focuses on pathological conditions of GPCR oligomerization in the central nervous system. Recently, he received the “ICREA Acadèmia” award from the Catalan Institution for Research and Advanced Studies, a foundation supported by the Catalan Government.



  
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