Podcast on “The Mitochondrial Permeability Transition Pore”
Journal of Molecular and Cellular Cardiology
Podcast on “The Mitochondrial Permeability Transition Pore”
Listen to Elizabeth (Tish) Murphy, Christopher Baines, Andrew Halestrap, and Fabio Di Lisa as they discuss the “Mitochondria special Issue: From Basic Mitochondrial Biology to Cardiovascular Disease”. Guest Edited by Elizabeth Murphy, Don Bers and Rosario Rizzuto.
Dr Andrew Halestrap is Professor of Biochemistry at the University of Bristol, and a founding member of The Bristol Heart Institute. His current research focuses on two distinct areas in which he has made seminal contributions over many years. One focuses on the structure, function and regulation of monocarboxylate transporters of the plasma and mitochondrial membranes. However, he is best known for his studies on the molecular mechanism and role of the mitochondrial permeability transition pore (MPTP) that is now accepted to play a critical role in reperfusion injury and cardioprotection. He was the first to demonstrate protection of both the heart and brain from reperfusion injury by inhibitors of MPTP opening, and has subsequently identified a range of protective regimes involving inhibition of pore opening that are leading to improvements of the cardioplegic solutions and perfusion protocols used in heart surgery. Dr Halestrap was elected a Fellow of the Academy of Medical Sciences in 2008 and has been invited to give the The Keilin Memorial Lecture of the Biochemical society in 2010.
Christopher P. Baines, Ph.D.
Chris Baines is an Assistant Professor in the Department of Biomedical Sciences and a Resident Investigator at The Dalton Cardiovascular Research Center at the University of Missouri-Columbia. He received his B.Sc. in Pharmacology from the University of Bath, Great Britain in 1995, and his Ph.D. in Physiology from the University of South Alabama in 1999. After one year at the University of Rochester where he learned biochemical and molecular biology techniques, Chris spent three years in Peipei Ping’s lab at the University of Louisville. It was here that Chris began his research interest in mitochondria and their role in cardiomyocyte death, especially with regards to the MPT pore. He continued then continued this research in Jeffery Molkentin’s lab at Cincinnati Children’s Hospital Medical Center. Chris joined the University of Missouri-Columbia in November 2008.
Dr. Fabio Di Lisa
Dr. Fabio Di Lisa, a Fellow of the ISHR, is Professor of Biochemistry at the University of Padova, Italy, and is Past President of the European Section of the ISHR. His scientific interest is centred on mitochondria and myofibrillar proteins. After training in studies on heart metabolism, he contributed to the elucidation of the relationships between mitochondrial dysfunction and cell death. In this respect he characterized the involvement of the permeability transition pore in myocardial ischemia by developing methods that are currently used in studies in isolated cells and intact hearts. Moving from the ischemia/reperfusion injury he is now focusing on the role of mitochondria in heart failure by characterizing processes involved in the mitochondrial formation of reactive oxygen species as causative factors of permeability transition and myofilament derangements.
Dr. Elizabeth Murphy
Dr. Elizabeth Murphy is a Head of the Cardiac Physiology Section in the Translational Medicine Branch at the National Heart, Lung and Blood Institute. She received her PhD from the University of Pennsylvania in Biochemistry, followed by postdoctoral studies in Physiology at Duke University, before joining the National Institutes of Health. She is an Associate Editor for the Journal of Molecular and Cellular Cardiology and she also serves on the editorial board of Circulation, Circulation Research, and the American Journal of Physiology. She is a Fellow of the ISHR and the AHA and a member of the Electrical Signaling, Transport and Arrhythmias NIH Study Section. She has served on a number of American Heart Association committees, and is President-elect of the American Section of the International Society for Heart Research. She has been invited to present the 2009 Keith Reimer Distinguished lecture for the ISHR. Her current research is focused on ionic and energetic alterations in cell death and cardioprotection, and the signaling pathways that control these events.
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