Good Ruminations or Bad Ruminations in the Depressed Brain?


Philadelphia, PA, August 22, 2011
 - All of us, at times, ruminate or brood on a problem in order to make the best possible decision in a complex situation. But sometimes, rumination becomes unproductive or even detrimental to making good life choices. Such is the case in depression, where non-productive ruminations are a common and distressing symptom of the disorder. In fact, individuals suffering from depression often ruminate about being depressed. This ruminative thinking can be either passive and maladaptive (i.e., worrying) or active and solution-focused (i.e., coping). New research by Stanford University researchers, published in Elsevier’s Biological Psychiatry, provides insights into how these types of rumination are represented in the brains of depressed persons.

The interactions of two distinct and competing neural networks, the default mode network (DMN) and the task positive network (TPN), are particularly relevant to this question. Whereas the DMN supports passive, self-related thought, the TPN underlies active thinking required for solving problems, explained study author J. Paul Hamilton.

Using brain imaging technology, Hamilton and his colleagues found that, in depressed patients, increasing levels of activity in the DMN relative to the TPN are associated with higher levels of maladaptive, depressive rumination and lower levels of adaptive, reflective rumination. These findings indicate that the DMN and TPN interact in depression to promote depression-related thinking, with stronger DMN influence associated with more worrying, less effective coping, and more severe depression.

“It makes sense that non-productive ruminations would engage default-mode networks in the brain as these systems enable the brain to ‘idle’ when humans are not focused on specific tasks,” commented Dr. John Krystal,editor of Biological Psychiatry. “Better understanding the factors that control the switch between these modes of function may provide insights into depression and its treatment.”
 

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Notes to editors
The article is “Default-Mode and Task-Positive Network Activity in Major Depressive Disorder: Implications for Adaptive and Maladaptive Rumination” by J. Paul Hamilton, Daniella J. Furman, Catie Chang, Moriah E. Thomason, Emily Dennis, and Ian H. Gotlib. The authors are affiliated with Stanford University, Stanford, California. The article appears in Biological Psychiatry, Volume 70, Number 4 (August 15, 2011), DOI 10.1016/j.biopsych.2011.02.003, published by Elsevier.

Full text of the article mentioned above is available upon request. Contact Chris J. Pfister at c.pfister@elsevier.com to obtain a copy or to schedule an interview.

About Biological Psychiatry
This international rapid-publication journal is the official journal of the Society of Biological Psychiatry. It covers a broad range of topics in psychiatric neuroscience and therapeutics. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and treatment of major neuropsychiatric disorders. Full-length reports of novel results, commentaries, case studies of unusual significance, and correspondence judged to be of high impact to the field are published, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. Concise reviews and editorials that focus on topics of current research and interest are also published rapidly.

Biological Psychiatry ( www.sobp.org/journal) is ranked 4th out of 126 Psychiatry titles and 15th out of 237 Neurosciences titles in the 2010 Journal Citations Reports® published by Thomson Reuters. The 2010 Impact Factor for Biological Psychiatry is 8.674.

About Elsevier

Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions — among them ScienceDirect, Scopus, Elsevier Research Intelligenceand ClinicalKey— and publishes over 2,500 journals, including The Lancet and Cell, and more than 33,000 book titles, including a number of iconic reference works. Elsevier is part of RELX Group plc, a world-leading provider of information solutions for professional customers across industries.

Media contact
Chris J. Pfister
Elsevier
+1 215 239 3266
c.pfister@elsevier.com