Are Teenage Brains Really Different?

MRI Studies Show Brain Changes in the Adolescent Brain Impact Cognition, Emotion and Behavior

Philadelphia, March 28, 2008 – Many parents are convinced that the brains of their teenage offspring are different than those of children and adults. New data confirms that this is the case. An article by Jay N. Giedd, MD, of the National Institute of Mental Health (NIMH), published in the April 2008 issue of the Journal of Adolescent Health describes how brain changes in the adolescent brain impact cognition, emotion and behavior.

Dr. Giedd reviews the results from the NIMH Longitudinal Brain Imaging Project. This study and others indicate that gray matter increases in volume until approximately the early teens and then decreases until old age. Pinning down these differences in a rigorous way had been elusive until MRI was developed, offering the capacity to provide extremely accurate quantifications of brain anatomy and physiology without the use of ionizing radiation.

Writing in the article, Dr. Giedd comments, “Adolescence is a time of substantial neurobiological and behavioral change, but the teen brain is not a broken or defective adult brain. The adaptive potential of the overproduction/selective elimination process, increased connectivity and integration of disparate brain functions, changing reward systems and frontal/limbic balance, and the accompanying behaviors of separation from family of origin, increased risk taking, and increased sensation seeking have been highly adaptive in our past and may be so in our future. These changes and the enormous plasticity of the teen brain make adolescence a time of great risk and great opportunity.”

In an accompanying editorial, Elizabeth R. McAnarney MD, Department of Pediatrics, University of Rochester Medical Center, comments, “Finally neuroscientists are able to go under the ‘…leathery membrane, surrounded by a protective moat of fluid, and completely encased in bone…’ to provide new insights into brain development. Changes in the brain during childhood and adolescent development that are being documented through exquisite imaging by Giedd and others hold the promise for the development of hypotheses about the potential origins of behaviors that we have observed clinically for years….”

“Novelty seeking/sensation seeking and risk taking,” Dr. McAnarney continues, “is the basis for considerable growth during adolescence, as well as for the seemingly reckless behavior of some adolescents. Novelty seeking/sensation seeking and risk taking are topics of growing interest as adolescent brain development is defined better and as morbidity from adolescent risk taking mounts….The implication of our growing knowledge of brain–behavior mechanisms of adolescent conditions should provide insights into the risk of particular adolescents for morbidity and mortality. Preliminary data are promising so that as we begin to understand the complexity of and specificity of each of these conditions, we shall be able to diagnose and treat conditions earlier.”

The NIMH Longitudinal Brain Imaging Project began in 1989. Participants visit the NIMH at approximately two-year intervals for brain imaging, neuropsychological and behavioral assessment and collection of DNA. As of September 2007, approximately 5000 scans from 2000 subjects have been acquired. Of these, 387 subjects, aged 3 to 27 years, have remained free of any psychopathology and serve as the models for typical brain development.

Three themes have emerged from this and other studies in this new era of adolescent neuroscience. The first is functional and structural increases in connectivity and integrative processing as distributed brain modules become more and more integrated. Using a literary metaphor, maturation would not be the addition of new letters but rather of combining earlier formed letters into words, and then words into sentences and then sentences into paragraphs.

The second is a general pattern of childhood peaks of gray matter (frontal lobe, parietal lobe, temporal lobe and occipital lobe) followed by adolescent declines. As parts of the brain are overdeveloped and then discarded, the structure of the brain becomes more refined.

The third theme is a changing balance between limbic/subcortical and frontal lobe functions that extends well into young adulthood as different cognitive and emotional systems mature at different rates. The cognitive and behavioral changes taking place during adolescence may be understood from the perspective of increased “executive” functioning, a term encompassing a broad array of abilities, including attention, response inhibition, regulation of emotion, organization and long-range planning.

The article is “The Teen Brain: Insights from Neuroimaging” by Jay N. Giedd, MD. The editorial is “Adolescent Brain Development: Forging New Links?” by Elizabeth R. McAnarney, MD. Both appear in the Journal of Adolescent Health, Volume 42, Issue 4 (April 2008) published by Elsevier.

# # #

Full text of the articles featured above is available upon request. To obtain the full text or schedule an interview, contact William S. Deutsch at (215) 239-3651 or w.deutsch@elsevier.com.

About the Journal of Adolescent Health
The pre-eminent, authoritative, peer-reviewed journal in the field of adolescent medicine for nearly 30 years, the Journal of Adolescent Health publishes new research findings ranging from the basic biological and behavioral sciences to public health and policy. The journal is the official publication of SAM, the Society for Adolescent Medicine, a multidisciplinary organization committed to improving the health and well-being of adolescents. One of the Society's primary goals is the development, synthesis, and dissemination of scientific and scholarly knowledge unique to the health needs of adolescents. To meet this goal, the Society established the Journal of Adolescent Health in 1980.

The Journal of Adolescent Health is ranked 8th out of 74 Pediatrics journals, and 17th out of 98 Public, Environmental & Occupational Health journals, with an impact factor of 2.710, according to the 2006 Journal Citation Reports®, published by Thomson Scientific.

About Elsevier

Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions — among them ScienceDirect, Scopus, Elsevier Research Intelligence,and ClinicalKey—and publishes over 2,200 journals, including The Lancet and Cell, and over 25,000 book titles, including a number of iconic reference works.

The company is part of Reed Elsevier Group PLC, a world leading provider of professional information solutions in the Science, Medical, Legal and Risk and Business sectors, which is jointly owned by Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).

Media Contact:
William Deutsch
Elsevier
+1 215 239 3651
w.deutsch@elsevier.com