Elsevier’s BrainNavigator 3.0 Reflects the Next Step in Enhancing Neurological Research

Digital Research Tool Now Includes Human and Rhesus Monkey Brain Content and Gene Expression Overlay

Burlington, MA, October 5, 2010 – Elsevier, the leading publisher of scientific, technical and medical information products and services, today announced a new version of its online research tool BrainNavigator. The first version, introduced in 2008,was well received by the neuroscience researcher community and received the prestigious PROSE Award in 2009. In the updated version, BrainNavigator 3.0, Elsevier has added critical new content and functionality to give researchers additional tools to accelerate their research.

BrainNavigator now includes the Rhesus Monkey atlas, developed by Editors-in-Chief, Professors George Paxinos and Charles Watson of the University of New South Wales in collaboration with Michael Petrides from McGill University in Montreal. BrainNavigator 3.0 also features the Atlas of the Human Brain, developed by Dr. Paxinos, Prof. Jürgen Mai and Dr. Thomas Voss at the University of Düsseldorf in Germany.

BrainNavigator is an online, interactive, 3D software tool that extends and advances the application of brain atlases and maps images of brain anatomy, helping neuroscience researchers save time and improve the quality of their daily research. BrainNavigator helps locate the position of structures within the brain, making visualization and communication about scientific findings about the brain easier.

“With BrainNavigator 3.0 we’ve addressed the wish lists of neuroscience researchers,” said Suzanne BeDell, Managing Director of Elsevier Science & Technology Books. “We’ve added even more cutting-edge content and functions that streamline the way researchers work—from conceptualizing their experiments to planning their surgeries to publishing their findings—BrainNavigator is there every step of the way, speeding research and improving results.” 

In addition to providing significant new functionalities designed to further support the neuroscientist’s workflow in the lab, the new version of BrainNavigator continues to integrate digitized versions of the leading atlases. Other new functions include:

• Linking to the Allen Mouse Brain Atlas gene expression database. The open online Allen Mouse Brain Atlas, created by the Allen Institute for Brain Science, is a critical go-to resource for neuroscientists. Based on the Allen Institute’s public application programming interface (API), users can now readily access Atlas data from within BrainNavigator. BrainNavigator 3.0—both free and subscription versions—allows users to easily overlay this gene expression data with anatomical information, helping them visualize which genes are expressed in various regions of the brain and to plan their experiments with greater accuracy, efficiency and validity.

• Create and save a series of slices from 3D to 2D. BrainNavigator 3.0 includes an improved version of its virtual brain slicing feature. Researchers are now able to determine the angle of the cut and subsequently virtually create a series of slices from one end of the brain to the other automatically, at their desired thickness. This process closely approaches the process in the lab with a real brain. The series of images can also be saved for use in the 2D Navigator for precise annotation and documentation of their work.

• Inclusion of fiber tracts. Over 70 new structures have been added for each rodent atlas. They are available in the 2D browser and in the 3D models. Fiber tracts are often used as landmarks in the brain, and when used with the injection planning tool, they allow users to plan so they can avoid penetrating certain areas as needed.

• Inclusion of the rat and mouse chemoarchitectonic atlases. The chemoarchitectonic images provide more accurate delineation of structures and having multiple sources to compare creates deeper understanding of the user’s own research.

“Users of our open online Allen Mouse Brain Atlas have long asked to be able to view our gene expression data in the anatomic framework developed by George Paxinos and Charles Watson,” said Allan Jones, Ph.D., chief exectuive officer of the Allen Institute for Brain Science. “Now, in both free and subscription-based versions, users can bring our data into the BrainNavigator environment and do just that.”

Offering both free and subscription-based content, BrainNavigator is used by the National Institutes of Health (NIH), Massachusetts Institute of Technology (MIT), Stanford University and other leading research institutions. Nothing in this press release constitutes or should be inferred to be an endorsement or recommendation of any product, service, or enterprise by the National Institutes of Health, any other agency of the United States Government, or any employee of the United States Government.

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About BrainNavigator 
BrainNavigator is a collaboration between Elsevier and the Allen Institute for Brain Science, pairing Elsevier’s vast neuroscience content with technology derived from Allen Institute’s cutting-edge Brain Explorer® 3D software. Offering both free and subscription-based content, this dynamic new resource represents a promising step towards new discoveries in the advancement of brain research. All users will be able to browse images and structures. Paid subscribers will enjoy using high resolution images, adjustable virtual slicing and having the ability to annotate and save their work and share it with their colleagues globally, among other features. Details regarding BrainNavigator’s functionality can be found at www.brainnav.com/info.

About the Allen Institute for Brain Science 
Launched in 2003, the Seattle-based Allen Institute for Brain Science is an independent, 501(c)(3) non-profit medical research organization dedicated to advancing brain research. Started with $100 million in seed money from philanthropist Paul G. Allen, the Institute takes on projects at the leading edge of science - far-reaching projects at the intersection of biology and technology. The resulting data create publicly available resources that fuel discovery for countless other researchers worldwide. The Institute’s data and tools are available on the Web free of charge at www.alleninstitute.org.

About Neuroscience Research Australia 
The work of Neuroscience Research Australia, formerly named the Prince of Wales Medical Research Institute, is directed to understanding the integrative actions of the brain and nervous system in health and disease. The brain and spinal cord control and coordinate everything that we think, speak, feel and do. Damage or disease of the brain produces devastating results. It can leave you unable to move, unable to speak, unable to control even your basic bodily functions. It may leave you with debilitating chronic pain.

The scientists at Neuroscience Research Australia, Sydney, Australia (www.powmri.edu.au) are dedicated to understanding every aspect of the nervous system. They also focus on translating their research into clinical practice to help diagnose and prevent disease and ultimately to look for curative therapies. The world leading research covers everything from cells, genes and molecules through to how the elderly walk, and from the tiniest blood vessel to the control of breathing.

About Elsevier

Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions — among them ScienceDirect, Scopus, Elsevier Research Intelligence,and ClinicalKey—and publishes over 2,200 journals, including The Lancet and Cell, and over 25,000 book titles, including a number of iconic reference works.

The company is part of Reed Elsevier Group PLC, a world leading provider of professional information solutions in the Science, Medical, Legal and Risk and Business sectors, which is jointly owned by Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).

Media contact 
Harald Boersma
Senior Manager, Corporate Relations, Elsevier
H.Boersma@elsevier.com 
+31 20 485 27 36