2008 Nobel Prize Medicine Articles

The Nobel Prize in Physiology or Medicine 2008

hausen-barre-sinoussi-montagnierThis year the Nobel Prize in Physiology or Medicine was divided between two discoveries of viruses involved in diseases that affect global health. Harald zur Hausen from Germany received one half for his discovery of “human papilloma viruses (HPV) causing cervical cancer” and the other half went jointly to Francoise Barre-Sinoussi and Luc Montagnier from France for their discovery of “Human immunodeficiency virus (HIV)”, the cause of AIDS.

Zur Hausen published most of his highly cited articles in Elsevier journals, and his discovery has ultimately led to the development of prophylactic vaccines against HPV acquisition.

In recognition of the importance of their work, we are pleased to make the laureates’ key articles published with Elsevier freely available:

Harard zur Hausen

zur Hausen, H.
Perspectives of contemporary papillomavirus research
(2006) Vaccine, 24 (SUPPL. 3), pp. iii-iv.

De Villiers, E.-M., Fauquet, C., Broker, T.R., Bernard, H.-U., Zur Hausen, H.
Classification of papillomaviruses
(2004) Virology, 324 (1), pp. 17-27.

Zur Hausen, H.
Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes
(1999) Seminars in Cancer Biology, 9 (6), pp. 405-411.

Zur Hausen, H.
Papillomavirus infections - A major cause of human cancers
(1996) Biochimica et Biophysica Acta - Reviews on Cancer, 1288 (2), pp. F55-F78.

De Villiers, E.-M., Wagner, D., Schneider, A., Wesch, H., Munz, F., Miklaw, H., Zur Hausen, H.
Human papillomavirus DNA in women without and with cytological abnormalities: Results of a 5-year follow-up study
(1992) Gynecologic Oncology, 44 (1), pp. 33-39.

Zur Hausen, H.
Human genital cancer: Synergism between two virus infections or synergism between a virus infection and initiating events?
(1982) Lancet, 2 (8312), pp. 1370-1372.

Francoise Barre-Sinoussi

Coëffier, E., Clément, J.-M., Cussac, V., Khodaei-Boorane, N., Jehanno, M., Rojas, M., Dridi, A., Latour, M., El Habib, R., Barré-Sinoussi, F., Hofnung, M., Leclerc, C.
Antigenicity and immunogenicity of the HIV-1 gp41 epitope ELDKWA inserted into permissive sites of the MalE protein
(2000) Vaccine, 19 (7-8), pp. 684-693.

Müller-Trutwin, M.C., Corbet, S., Dias Tavares, M., Hervé, V.M.A., Nerrienet, E., Georges-Courbot, M.-C., Saurin, W., Sonigo, P., Barré-Sinoussi, F.
The evolutionary rate of nonpathogenic simian immunodeficiency virus (SIVagm) is in agreement with a rapid and continuous replication in vivo
(1996) Virology, 223 (1), pp. 89-102.

Barré-Sinoussi, F.
HIV as the cause of AIDS
(1996) Lancet, 348 (9019), pp. 31-35.

Spire, B., Sire, J., Zachar, V., Rey, F., Barre-Sinoussi, F., Galibert, F., Hampe, A., Chermann, J.-C.
Nucleotide sequence of HIV1-NDK: A highly cytopathic strain of the human immunodeficiency virus
(1989) Gene, 81 (2), pp. 275-284.

Ono, K., Nakane, H., Fukushima, M., Chermann, J.-C., Barré-Sinoussi, F.
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone
(1989) Biochemical and Biophysical Research Communications, 160 (3), pp. 982-987.

Ellrodt, A., Le Bras Ph., Barre-Sinoussi, F.
Isolation of human T-lymphotropic retrovirus (LAV) from Zairian married couple, one with AIDS, one with prodromes
(1984) Lancet, 1 (8391), pp. 1383-1385.

Luc Montagnier

Zennou, V., Petit, C., Guetard, D., Nerhbass, U., Montagnier, L., Charneau, P.
HIV-1 genome nuclear import is mediated by a central DNA flap
(2000) Cell, 101 (2), pp. 173-185.

Quillent, C., Oberlin, E., Braun, J., Rousset, D., Gonzalez-Canali, G., Métais, P., Montagnier, L., Virelizier, J.-L., Arenzana-Seisdedos, F., Beretta, A.
HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene
(1998) Lancet, 351 (9095), pp. 14-18.

Blanchard, A., Montagnier, L., Gougeon, M.-L.
Influence of microbial infections on the progression of HIV disease
(1997) Trends in Microbiology, 5 (8), pp. 326-331.

Khatissian, E., Monceaux, V., Cumont, M.-C., Montagnier, L., Hurtrel, B., Chakrabarti, L.
Interferon-gamma expression in macaque lymph nodes during primary infection with simian immunodeficiency virus
(1996) Cytokine, 8 (11), pp. 844-852.

Lopez, O., Bonnefont-Rousselot, D., Mollereau, M., Olivier, R., Montagnier, L., Emerit, J., Gentilini, M., Delattre, J.
Increased plasma thiobarbituric acid-reactive substances (TBARS) before opportunistic infection symptoms in HIV infected individuals
(1996) Clinica Chimica Acta, 247 (1-2), pp. 181-187.

Chakrabarti, L., Baptiste, V., Khatissian, E., Cumont, M.-C., Aubertin, A.-M., Montagnier, L., Hurtrel, B.
Limited viral spread and rapid immune response in lymph nodes of macaques inoculated with attenuated simian immunodeficiency virus
(1995) Virology, 213 (2), pp. 535-548.