Vitamin Deficiency After Weight Loss Surgery Can Cause Vision Loss in Newborns

Case study reported in the Journal of AAPOS

St. Louis, MO, July 16, 2010 – Biliopancreatic diversion surgery for morbid obesity is known to cause multiple vitamin deficiencies that may worsen during pregnancy. In the June issue of the Journal of AAPOS, the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus, a group of Australian clinicians report a child who was born blind as a result of Vitamin A deficiency caused by his mother’s obesity surgery.

Clinical investigators from Australia documented the case of a woman who had undergone biliopancreatic diversion surgery for obesity 7 years before the birth of her child. At 9 weeks gestation, the mother was diagnosed with severe deficiencies of Vitamins A, D and K, as well as iron-deficiency anemia, which had been undetected prior to this point. Despite treatment, her serum vitamin A level remained critically low throughout the pregnancy. Her infant son had significant malformations of both eyes, and his vision remains poor despite treatment. For the fetus, the first 8 weeks of gestation are the most critical time for organs to develop, including the formation of the visual system,

Lead investigator Glen Gole, MD, FRANZCO, Department of Ophthalmology, Royal Children’s Hospital and Discipline of Paediatrics and Child Health, University of Queensland, Brisbane, states, “The mother’s description of night blindness, recurrent low vitamin A levels during the pregnancy, and demonstrated vitamin A deficiency in the neonate support vitamin A deficiency as the cause. This case illustrates that vitamin A is very important for normal eye development in the fetus, particularly for pregnant women who have undergone gastric bypass surgery in order to improve their fertility.”

Commenting on the article, J AAPOS Editor-in-Chief David G. Hunter, MD, PhD, stated, "Weight-reduction surgery is becoming more common, especially with the potential for health benefits that result from reducing obesity. Unfortunately some forms of this surgery cause vitamin deficiency, and in this case the problem led to a birth defect that caused blindness in one child. We are not aware of any other cases of this particular problem, but it is important for any woman who has had this form of gastric bypass surgery to be checked for vitamin deficiency--and have it corrected—before considering having a baby."

The article is “Ocular malformation in a newborn secondary to maternal hypovitaminosis A” by Hannah Gilchrist, MBBS, Deepa A. Taranath, MS, FRANZCO, and Glen A. Gole, MD, FRANZCO. It appears in the Journal of AAPOS, Volume 14, Issue 3, (June 2010) published by Elsevier. doi:10.1016/j.jaapos.2010.01.015

Full text of the article is available to journalists upon request; contact Lynelle Korte at 314-447-9227 or via email at l.korte@elsevier.com to obtain a copy. Journalists wishing to conduct an interview should contact David G. Hunter, MD, PhD, Editor-in-Chief, The Journal of AAPOS (Children's Hospital Boston and Harvard Medical School), at 617-355-6766 or via email at editor@jaapos.org.

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Notes for Editors
Authors:
Hannah Gilchrist, MBBS
Department of Ophthalmology, Royal Children’s Hospital
Brisbane, Queensland, Australia

Deepa A. Taranath, MS, FRANZCO
Department of Ophthalmology, Flinders Medical Centre
Adelaide, South Australia, Australia;

Glen A. Gole, MD, FRANZCO
Department of Ophthalmology, Royal Children’s Hospital
Brisbane, Queensland, Australia and Discipline of Paediatrics and Child Health, University of Queensland
Brisbane, Queensland, Australia

About Journal of AAPOS (http://www.journals.elsevierhealth.com/periodicals/ympa)
Journal of AAPOS presents expert information on children's eye diseases and on strabismus as it impacts all age groups. Major articles by leading experts in the field cover clinical and investigative studies, treatments, case reports, surgical techniques, descriptions of instrumentation, current concept reviews and new diagnostic techniques. The Journal is the official publication of the American Association for Pediatric Ophthalmology and Strabismus.

About the American Association for Pediatric Ophthalmology and Strabismus (www.aapos.org)
The goals of AAPOS, the American Association for Pediatric Ophthalmology and Strabismus are to advance the quality of children's eye care, support the training of pediatric ophthalmologists, support research activities in pediatric ophthalmology and advance the care of adults with strabismus.

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Media Contact:
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Elsevier
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l.korte@elsevier.com