Books in Neuroscience

1-10 of 2040 results in All results

Vagus Nerve Stimulation

1st Edition
November 1, 2024
Peter Staats + 3 more
English
Hardback
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eBook
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The vagus nerve is one of the most important, yet most under-appreciated structures of the human body. It is the tenth cranial nerve innervating many of the visceral structures of the human body. It has been called the “wandering” nerve, given its ubiquitous and meandering course throughout the body. The major branch of the parasympathetic nervous system, it optimizes the body’s state of rest, relaxation and recovery and is necessary to optimize health. It is a counterbalance to the sympathetic nervous system, which regulates the body’s fight or flight response. Containing over 160,000 fibers, it has both afferent and efferent branches, providing information to the brain on the status of the body’s organs. The brain then sends signals back down the vagus nerve to optimize bodily functions. Vagus nerve stimulation is a new frontier in medicine, tapping into the body’s intrinsic capability to optimize an organ’s function, control systemic inflammation and modify diseases without drugs. The use of non-implanted vagus nerve stimulators has made it possible to move neuromodulation up the treatment continuum, and has facilitated access for clinical evaluation and treatment. Scientists now have the ability to translate the basic science into clinical practice without the need for surgical intervention. Vagus Nerve Stimulation serves as a compendium of current knowledge about stimulating the vagus nerve in many different disease states. Chapters include applications to neurologic conditions, psychiatric conditions, inflammatory conditions, metabolic disease, reperfusion injuries, long covid, cardiac disease and even optimizing performance in healthy individuals.

Early Detection in Alzheimer's Disease

1st Edition
November 1, 2024
Dennis Chan
English
Paperback
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eBook
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Early Detection of Alzheimer’s Disease: Biological and Technological Advances aims to introduce to a wide audience the high global priority problem of detecting AD prior to dementia onset. According to the Alzheimer’s Association, 5.8 million Americans are living with Alzheimer’s and care costs will cost the nation approximately $290 billion (2019 Alzheimer’s Disease Facts and Figures). With the failure of recent AD drug trials, many hypothesize that by the time symptoms appear, it is too late to be treated. Early detection can offer benefits such as more choice of medications, ability to participate in clinical trials, more time for family and for care planning. This book outlines potential solutions to the above problem using opportunities arising from the technology revolution, advances in neuroscience, and molecular biology. Most importantly, it discusses a paradigm shift from a reactive to a proactive diagnostic approach, aiming to detect disease before occurrence of symptoms. Topics covered include the use of sensing technologies (e.g. smartphones, smartwatches, Internet of Things) to detect early disease-related changes, the application of data science (machine learning/AI) to extract otherwise invisible disease features from these datasets and the potential to personalize diagnosis based on tracking changes in individual behaviours. Advances in blood-based biomarkers, brain imaging, and the potential for early diagnosis to aid interventions (lifestyle, dietary, pharmacological) to delay future development of dementia are also discussed.

Chemical Receptor Sensory Systems

1st Edition
November 1, 2024
Kyle Palmer
English
Paperback
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eBook
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Chemical Receptor Sensory Systems explores chemosenses through the lens of pharmacologic theory, and how chemosensory systems, from the molecular level to the behavior of organisms, must behave given that their operations are functions of receptor pharmacodynamics and pharmacokinetics. Throughout the book, information on concentration-dependence of chemical stimulation and likely relationship to receptor occupancy is strongly emphasized. In cases where a departure from expected pharmacologic behavior is encountered in the chemosenses, the discussion is directed toward probable explanations for the apparent disconnect. This book provides a new resource that on all chemosenses topics within a unifying conceptual framework of the science of pharmacology. It will be useful to a variety of researchers and graduate students in pharmacology, biology and physiology of sensory systems, researchers in sensory psychology, research scientists in food & nutritional scientists, as well as clinical staff.

Neurobiology of Infectious Diseases

1st Edition
Volume 1
November 1, 2024
Tatiana Barichello + 2 more
English
Paperback
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eBook
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Neurobiology of Infectious Diseases covers mechanisms underlying infectious diseases. It is divided into six distinct sections, beginning with the foundations of Neuroinfection. This section includes chapters on the role microbiota-gut-brain axis and specialized blood-neuronal barriers play in neurobiology of infectious diseases. The next three sections detail various bacterial infections, parasitic infections, viral infections, and fungal infections of the central nervous system. The last section reviews the proteins and other peripheral mediators that affect the central nervous system. Internationally contributed by experts in the field this book sets the foundation of neurobiology and infectious disease.Neurobiology is the study of cells of the nervous system and the organization of these cells into functional circuits that process information and mediate behavior. Current research is vital for determining pharmaceutical and medicinal treatments for neurological disorders, psychiatric disorders and diseases.

Brain and Organ Communication

1st Edition
November 1, 2024
Charu Mahajan + 2 more
English
Paperback
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eBook
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Brain and Organ Communication: Effects of Crosstalk on Neurophysiology examines the intricate relationship between the brain and other organ systems within the body. With an emphasis on homeostasis of these systems, this book also explores how various systems are related and affected by the brain injury or organ damage from a neurophysiological standpoint.This book will be most useful to researchers in neuroscience and graduate students studying neurophysiology. Those with an interest in endocrinology and clinicians in various branches of neuroscience and physiology will also find this book of interest.

Genome Editing for Neurodegenerative Diseases

1st Edition
November 1, 2024
Sandeep Kumar Singh + 3 more
English
Paperback
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eBook
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Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical applications. With an emphasis on genome editing tools such as ZFNs, TALENSs and CRISPR-Cas, this book sheds light on the possibilities to counteract genetic and neurodegenerative diseases. It will be of interest to researchers in neuroscience and biopharmaceuticals, as well as clinicians specializing in neurodegenerative diseases.

Advances in Substance Use Disorder Treatment

1st Edition
Volume 178
November 1, 2024
Rosana Camarini + 1 more
English
Hardback
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eBook
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Advances in Substance Use Disorder Treatment, Volume 178 in the International Review in Neurobiology series presents a comprehensive exploration of emerging therapies and approaches in the field. Advances in the Treatment of Alcohol Use Disorder offers an in-depth exploration of the forefront of research and innovation in addressing the treatment of alcohol use disorder (AUD). Leading experts contribute chapters that investigate the potential of diverse therapeutic modalities, ranging from neurobiological approaches such as oxytocin and vasopressin, GABAergic compounds, the CRF system, and neuroactive steroids to pharmacological interventions like ALDH2 activators, anti-inflammatories, and mesenchymal stem cells. This volume also examines unconventional yet promising treatments, including sodium oxybate, modulators of the ghrelin and GLP-1 systems, psychedelic compounds, and cannabinoids. It extends to explore the impact of environmental enrichment on the treatment of AUD and the use of animal models in elucidating translational challenges. By integrating pre-clinical and clinical perspectives, this book serves as an essential resource for professionals, scholars, and clinicians dedicated to advancing our understanding and treatment of AUD.

Clinician’s Guide to Headache

1st Edition
October 18, 2024
Pravin Thomas
English
Paperback
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eBook
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Clinician’s Guide to Headache: Head, Neck and Face Pain Syndromes is a comprehensive reference that covers what headache specialists encounter in day-to-day headache practice settings. This practical volume is relevant as a primary reference for neurologists and other headache specialists looking for a resource on complex, acute headache management. Developments in the field are highlighted, including biologics and invasive and non-invasive neuromodulation. Chapters focus on anatomy and pathophysiology, neuroradiology, acute and chronic headaches, and clinically relevant sections on diagnosis and biases, consultation settings, placebos and nocebos, as well as the set-up of a comprehensive headache center.With a foundation based on recent developments in pathophysiology and anatomy, this volume provides an overview of headache disorders with a case-based approach.

Cell and Gene Therapies for Neurologic Diseases

1st Edition
Volume 205
October 1, 2024
Howard J. Federoff + 1 more
English
Hardback
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eBook
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Cell and Gene Therapies for Neurologic Diseases, Volume 205 comprehensively covers the scientific background, translational efforts, clinical developments and registered biologics that have entered into clinical practice. Coverage includes types of therapies available and in development, and best practice uses for a variety of neurological disorders including Parkinson’s, Huntington’s, ALS, stroke, spinal cord RP, demyelination, and epilepsy. As the emergence of gene and cellular therapeutics has changed the clinical landscape for a variety of disorders, and is now ready to do so for neurological diseases, these therapeutic modalities currently complement, and may in time, supplant small molecule drugs.

Osteomyelitis and Discitis of the Spine

1st Edition
October 1, 2024
Dia R Halalmeh + 1 more
English
Paperback
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eBook
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Osteomyelitis and Discitis of the Spine: A Guide for the Management of Infectious Etiology of the Vertebral Column and Neurological Components examines these spinal conditions and provides readers with the most appropriate management plans, including surgical treatment together with its indications. This book guides spine neurosurgeons and others when choosing the optimal surgical approach for their patients, shedding light on current advances in surgical techniques used in the management of vertebral osteomyelitis and discitis, particularly minimally invasive spine approaches.With authors representing diverse specialties, chapters reflect current clinical and surgical practice and discuss pathophysiology and pain management and rehabilitation. The book begins with related anatomy and extends to post-management rehabilitation and pain control, including a chapter dedicated to pediatric patients and their differing causative organisms, etiology, diagnostic modalities, and pathophysiology. This reference will provide increased awareness of potential spinal infection, facilitating multidisciplinary management plans, improving patient safety and outcomes, and enabling early intervention alternatives that improve patient outcomes and long-term quality of life.