Top 25 Hottest Biochemistry Articles

Potential of a Pycnoporus sanguineus laccase in bioremediation of wastewater and kinetic activation in the presence of an anthraquinonic acid dye * Article
Enzyme and Microbial Technology | Trovaslet, M.; Enaud, E.; Guiavarc\'h, Y.; Corbisier, A.M.; Vanhulle, S.

Hallmarks of Cancer: The Next Generation * Review article
Cell, Volume 144, Issue 5, Pages 646-674 | Hanahan, D.; Weinberg, Robert A.

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors * Article
Cell, Volume 126, Issue 4, Pages 663-676 | Takahashi, K.; Yamanaka, S.

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling * Article
Cell, Volume 159, Issue 2, Pages 440-455 | Platt, Randall J.; Chen, S.; Zhou, Y.; Yim, Michael J.; Swiech, L.; Kempton, Hannah R.; Dahlman, James E.; Parnas, O.; Eisenhaure, Thomas M.; Jovanovic, M.; Graham, Daniel B.; Jhunjhunwala, S.; Heidenreich, M.; Xavier, Ramnik J.; Langer, R.; Anderson, Dan

The Hallmarks of Cancer * Review article
Cell, Volume 100, Issue 1, Pages 57-70 | Hanahan, D.; Weinberg, R.A.

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering * Review article
Trends in Biotechnology, Volume 31, Issue 7, Pages 397-405 | Gaj, T.; Gersbach, C.A.; Barbas, C.F.

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering * Article
Cell, Volume 153, Issue 4, Pages 910-918 | Wang, H.; Yang, H.; Shivalila, Chikdu S.; Dawlaty, Meelad M.; Cheng, Albert W.; Zhang, F.; Jaenisch, R.

Development and Applications of CRISPR-Cas9 for Genome Engineering * Review article
Cell, Volume 157, Issue 6, Pages 1262-1278 | Hsu, Patrick D.; Lander, Eric S.; Zhang, F.

Hydrolysis of lignocellulosic materials for ethanol production: a review * Article
Bioresource Technology, Volume 83, Issue 1, Pages 1-11 | Sun, Y.; Cheng, J.

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity * Article
Cell, Volume 154, Issue 6, Pages 1380-1389 | Ran, F.; Hsu, Patrick D.; Lin, C.Y.; Gootenberg, Jonathan S.; Konermann, S.; Trevino, A.E.; Scott, David A.; Inoue, A.; Matoba, S.; Zhang, Y.; Zhang, F.

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering * Article
Cell, Volume 154, Issue 6, Pages 1370-1379 | Yang, H.; Wang, H.; Shivalila, Chikdu S.; Cheng, Albert W.; Shi, L.; Jaenisch, R.

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System * Article
Cell, Volume 155, Issue 7, Pages 1479-1491 | Chen, B.; Gilbert, Luke A.; Cimini, Beth A.; Schnitzbauer, J.; Zhang, W.; Li, G.W.; Park, J.; Blackburn, Elizabeth H.; Weissman, Jonathan S.; Qi, Lei S.; Huang, B.

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA * Article
Cell, Volume 156, Issue 5, Pages 935-949 | Nishimasu, H.; Ran, F.; Hsu, Patrick D.; Konermann, S.; Shehata, Soraya I.; Dohmae, N.; Ishitani, R.; Zhang, F.; Nureki, O.

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos * Article
Cell, Volume 156, Issue 4, Pages 836-843 | Niu, Y.; Shen, B.; Cui, Y.; Chen, Y.; Wang, J.; Wang, L.; Kang, Y.; Zhao, X.; Si, W.; Li, W.; Xiang, A.; Zhou, J.; Guo, X.; Bi, Y.; Si, C.; Hu, B.; Dong, G.; Wang, H.; Zhou, Z.; Li, T.; Tan, T.; Pu, X.; Wang, F.; Ji, S.; Zhou, Q.; Huang, X.; Ji, W.; Sha,

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation * Article
Cell, Volume 159, Issue 3, Pages 647-661 | Gilbert, Luke A.; Horlbeck, Max A.; Adamson, B.; Villalta, Jacqueline E.; Chen, Y.; Whitehead, Evan H.; Guimaraes, C.; Panning, B.; Ploegh, Hidde L.; Bassik, Michael C.; Qi, Lei S.; Kampmann, M.; Weissman, Jonathan S.

Generation of Functional Human Pancreatic @b Cells In Vitro * Article
Cell, Volume 159, Issue 2, Pages 428-439 | Pagliuca, Felicia W.; Millman, Jeffrey R.; Gurtler, M.; Segel, M.; Van Dervort, A.; Ryu, J.; Peterson, Quinn P.; Greiner, D.; Melton, Douglas A.

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders * Article
Cell, Volume 155, Issue 7, Pages 1451-1463 | Hsiao, Elaine Y.; McBride, Sara W.; Hsien, S.; Sharon, G.; Hyde, Embriette R.; McCue, T.; Codelli, Julian A.; Chow, J.; Reisman, Sarah E.; Petrosino, Joseph F.; Patterson, Paul H.; Mazmanian, Sarkis K.

Radical scavenging activity of various extracts and fractions of sweet orange peel (Citrus sinensis) * Article
Food Chemistry, Volume 94, Issue 1, Pages 19-25 | Anagnostopoulou, M.A.; Kefalas, P.; Papageorgiou, V.P.; Assimopoulou, A.N.; Boskou, D.

Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis * Article
Cell, Volume 157, Issue 3, Pages 726-739 | Susaki, Etsuo A.; Tainaka, K.; Perrin, D.; Kishino, F.; Tawara, T.; Watanabe, Tomonobu M.; Yokoyama, C.; Onoe, H.; Eguchi, M.; Yamaguchi, S.; Abe, T.; Kiyonari, H.; Shimizu, Y.; Miyawaki, A.; Yokota, H.; Ueda, Hiroki R.

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors * Article
Cell, Volume 131, Issue 5, Pages 861-872 | Takahashi, K.; Tanabe, K.; Ohnuki, M.; Narita, M.; Ichisaka, T.; Tomoda, K.; Yamanaka, S.

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2^-^@D^@D^C^T Method * Article
Methods, Volume 25, Issue 4, Pages 402-408 | Livak, K.J.; Schmittgen, T.D.

Declining NAD^+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging * Article
Cell, Volume 155, Issue 7, Pages 1624-1638 | Gomes, Ana P.; Price, Nathan L.; Ling, Alvin J.Y.; Moslehi, Javid J.; Montgomery, M.K.; Rajman, L.; White, James P.; Teodoro, Joao S.; Wrann, Christiane D.; Hubbard, Basil P.; Mercken, Evi M.; Palmeira, Carlos M.; de Cabo, R.; Rolo, Anabela P.; Turner, N.

Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications * Review article
Biomaterials, Volume 26, Issue 18, Pages 3995-4021 | Gupta, A.K.; Gupta, M.

The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones * Review article
Cell, Volume 157, Issue 1, Pages 77-94 | Cech, Thomas R.; Steitz, Joan A.

Transgenerational Epigenetic Inheritance: Myths and Mechanisms * Review article
Cell, Volume 157, Issue 1, Pages 95-109 | Heard, E.; Martienssen, Robert A.