Dr. Zack’s laboratory focuses mainly on studying the pathogenic processes in HIV infection by employing primary cell systems. His laboratory pioneered the use of mouse/human chimeric models to study HIV pathogenesis in vivo. These chimeric mouse models can also be used to direct differentiation of human stem cells towards the T cell lineage. Recent work in the Zack lab has focused on finding means to eliminate latent HIV reservoirs, and on genetic engineering of human immune responses via engineering of stem cells. Current studies involve in vivo modeling of these approaches in humanized mice.
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