Tetrahedron Letters offers rapid publication of important new developments in organic chemistry. Articles should be in the form of short communications announcing either experimental or theoretical results of special interest.
The contents of papers are the sole responsibility of the authors, and publication shall not imply the concurrence of the Editors or Publisher.Ethics in publishing
Please see our information pages on Ethics in publishing and Ethical guidelines for journal publication.
Declaration of interest
All authors are requested to disclose any actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations within three years of beginning the submitted work that could inappropriately influence, or be perceived to influence, their work. More information.
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Changes to authorship
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Only in exceptional circumstances will the Editor consider the addition, deletion or rearrangement of authors after the manuscript has been accepted. While the Editor considers the request, publication of the manuscript will be suspended. If the manuscript has already been published in an online issue, any requests approved by the Editor will result in a corrigendum.
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Find out how you can share your research published in Elsevier journals.
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This journal has an embargo period of 24 months.
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Submission of an article implies that the work described has not been published previously (except in the form of an abstract or as part of a published lecture or academic thesis), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, without the written consent of the copyright holder. Authors accept full responsibility for the factual accuracy of the data presented and should obtain any authorization necessary for publication. As such the contents of the papers are the sole responsibility of the authors and publication shall not imply the concurrence of the editors or copyright holder.
All papers are submitted to referees who advise the editor on the matter of acceptance in accordance with the high standards required, on the understanding that the subject matter has not been previously published and is not under consideration elsewhere. Referees will be asked to distinguish contributions meeting the above requirements and having an element of novelty, timeliness, and urgency that merits publication in the journal. We ask referees to help in the selection of articles that have this breadth and suggest that papers covering narrower aspects of the field be sent to journals specializing in those areas. Referee names are not disclosed, but their views are forwarded by the editor to the authors for consideration. Authors are encouraged to suggest names of several experts in the field when papers are first submitted or at any time in the evaluation process.
Our online submission system guides you stepwise through the process of entering your article details and uploading your files. The system converts your article files to a single PDF file used in the peer-review process. Editable files (e.g., Word, LaTeX) are required to typeset your article for final publication. All correspondence, including notification of the Editor's decision and requests for revision, is sent by e-mail.
Authors should submit their manuscripts to the appropriate regional editor (see below) via the online submission page of this journal at http://ees.elsevier.com/tetl. Authors will be guided stepwise through the creation and uploading of the various files. The system automatically converts source files to a single Adobe Acrobat PDF version of the article, which is used in the peer review process. Please note that even though manuscript source files are converted to PDF at submission for the review process, these source files are needed for further processing after acceptance. All correspondence, including notification of the editor's decision and requests for revision, takes place by e-mail and via the author's home page. A printed copy of the manuscript is not required at any stage of the process.
- Manuscript. It is not necessary to embed graphics in the text, but if you do so please note that separate graphic files will always be required for proof production when a manuscript is accepted for publication. Graphics should be submitted as separate, highresolution artwork files. These will be automatically incorporated into the single PDF that the system creates for review.
- Graphical abstract for the contents list (submitted as a separate document).
- Cover letter: highlighting the novelty, significance, and urgency of the submitted work, which merits rapid publication and providing details of other relevant information, e.g., submitted or in press manuscripts.
- List of potential referees (Separate document).
- Mol files (optional): see below.
Manuscripts should be addressed to the appropriate regional editor: Articles from Austria, Belgium, France, Germany, Portugal, Spain and Switzerland:
Professor S. Z. Zard, Laboratoire de Synthèse Organique, École Polytechnique, F-91128 Palaiseau Cedex, France.
Professor Lin Guo-Qiang, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China (manuscripts from Taiwan may be sent to Professor Lin, or to the usual Editor in Japan, at the choice of the authors).
Professor K. Maruoka, Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
Professor V.K. Singh, IISER Bhopal, Indore By-pass Road, Bhauri, Bhopal 462 066, India.
Asymmetric and Combinatorial Synthesis, Heterocycles, Organometallic Chemistry, Physical Organic Chemistry, Radicals, Small Rings, Strained Systems, Theory and Total Synthesis
Professor J. Wood, A. I. Meyers Professor of Chemistry, Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
All regions other than those specified above:
Professor E. J. Thomas, Department of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
The Americas: Professor B. Stoltz, Division of Chemistry and Chemical Engineering, California Institute of Technology, USAEurope and Middle East: Professor M. Christmann, Freie Universität Berlin, Berlin, Germany
China, Hong Kong, Macau, South Korea, New Zealand: Dr J. Hu, Chinese Academy of Sciences (CAS), Shanghai, ChinaJapan, Thailand, Taiwan, Singapore, Australia, India: Professor M. Kitamura, Nagoya University, Nagoya, Japan Templates
Templates are provided in order to allow authors to view their paper in a style close to the final printed form. Their use is optional. The templates can be found at http://www.elsevier.com/tetrahedron-templates.
All manuscripts will be fully typeset from the author's electronic files. It should be noted that due to defined typesetting standards and the complex requirements of electronic publishing, the Publisher will not always be able to exactly match the layout the author has submitted. In particular, in the finished journal article, figures and tables are usually placed at the top or bottom of pages. The template is only intended to be used in assisting with the preparation and submission of manuscripts.
It should be noted that the use of the journal template is not a requirement and its adoption will neither speed nor delay publication. Elsevier can handle most major word processing packages and in general most formatting applied by authors for style and layout is replaced when the article is being typeset.
These templates contain a large number of macros. To ensure successful PDF conversion by the online submission system, it is important that the author saves a new document based on the template, rather than saving the template itself. To use the template, the author should save the final document as a Word file with a ".doc" extension (rather than the ".dot" extension). Please use TrueType fonts in order to avoid problems with the creation of the PDF.
Please ensure that the graphical abstract is included as page 1 of your manuscript when submitting online. For detailed instructions on the preparation of electronic artwork, see http://www.elsevier.com/artworkinstructions.
The corresponding author's full mailing address, including mail codes, phone number, fax number, and e-mail address should be included. The manuscript should be compiled in the following order: Graphical Abstract, Title, Authors, Affiliations, Abstract, Keywords, Introduction, Results, Discussion, Conclusion, Experimental, Acknowledgments, References and Notes, Tables, Legends, Figures, and Schemes.
Text should be subdivided in the simplest possible way consistent with clarity. Headings should reflect the relative importance of the sections. Ensure that all tables, figures, and schemes are cited in the text in numerical order. The preferred position for chemical structures should be indicated. Trade names should have an initial capital letter. All measurements and data should be given in SI units where possible, or in other internationally accepted units. Abbreviations should be used consistently throughout the text, and all non-standard abbreviations should be defined on first usage. Authors are requested to draw attention to hazardous materials or procedures by adding the word CAUTION followed by a brief descriptive phrase and literature references if appropriate.
Essential title page information
• Title. Concise and informative. Titles are often used in information-retrieval systems. Avoid abbreviations and formulae where possible.
• Author names and affiliations. Please clearly indicate the given name(s) and family name(s) of each author and check that all names are accurately spelled. Present the authors' affiliation addresses (where the actual work was done) below the names. Indicate all affiliations with a lower-case superscript letter immediately after the author's name and in front of the appropriate address. Provide the full postal address of each affiliation, including the country name and, if available, the e-mail address of each author.
• Corresponding author. Clearly indicate who will handle correspondence at all stages of refereeing and publication, also post-publication. Ensure that the e-mail address is given and that contact details are kept up to date by the corresponding author.
• Present/permanent address. If an author has moved since the work described in the article was done, or was visiting at the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to that author's name. The address at which the author actually did the work must be retained as the main, affiliation address. Superscript Arabic numerals are used for such footnotes.
Authors must include a short abstract of approximately four to six lines that states briefly the purpose of the research, the principal results, and major conclusion(s). References and compound numbers should not be mentioned in the abstract unless full details are given.
A Graphical abstract is mandatory for this journal. It should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership online. Authors must provide images that clearly represent the work described in the article. Graphical abstracts should be submitted as a separate file in the online submission system. Image size: please provide an image with a minimum of 531 × 1328 pixels (h × w) or proportionally more. The image should be readable at a size of 5 × 13 cm using a regular screen resolution of 96 dpi. Preferred file types: TIFF, EPS, PDF or MS Office files. You can view Example Graphical Abstracts on our information site.
Authors can make use of Elsevier's Illustration and Enhancement service to ensure the best presentation of their images also in accordance with all technical requirements: Illustration Service.
Highlights are a short collection of bullet points that convey the core findings of the article. Highlights are optional and should be submitted in a separate editable file in the online submission system. Please use 'Highlights' in the file name and include 3 to 5 bullet points (maximum 85 characters, including spaces, per bullet point). You can view example Highlights on our information site. Acknowledgements
An acknowledgement section may be included. It should be placed after the manuscript text and before the references.
It is not necessary to include detailed descriptions on the program or type of grants and awards. When funding is from a block grant or other resources available to a university, college, or other research institution, submit the name of the institute or organization that provided the funding.If no funding has been provided for the research, please include the following sentence:
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.Nomenclature
It is the responsibility of the authors to provide correct nomenclature. Chemical names for drugs are preferred. If these are not practical, generic names, names approved by the U.S. Adopted Names Council, or those approved by the World Health Organization may be used. If a generic name is used, its chemical name or structure should be provided at the point of first citation. Authors will find the following as useful reference books for recommended nomenclature.
IUPAC Nomenclature of Organic Chemistry; Rigaudy, J.; Klesney, S. P., Eds; Pergamon: Oxford, 1979.
Enzyme Nomenclature; Webb, E. C., Ed.; Academic Press; Orlando, 1992.
Biochemical Nomenclature and Related Documents; The Biochemistry Society; London, 1978.
The ACS Style Guide; Dodd, J. S., Ed.; American Chemical Society: Washington, DC, 1997.
Prior to submission of the manuscript, the author should deposit crystallographic data for organic and metalorganic structures with the Cambridge Crystallographic Data Centre. The data, without structure factors, should be sent by e-mail to firstname.lastname@example.org, as an ASCII file, preferably in CIF format. Hard copy data should be sent to CCDC, 12 Union Road, Cambridge CB2 1EZ. A checklist of data items for deposition can be obtained from the CCDC Home Page on the World Wide Web (http://www.ccdc.cam.ac.uk) or by e-mail to: email@example.com, with the one-line message, send me checklist. The data will be acknowledged, within three working days, with one CCDC deposition number per structure deposited. These numbers should be included with the following standard text in the manuscript: Crystallographic data (excluding structure factors) for the structures in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication nos. CCDC. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK, (fax: +44-(0)1223-336033 or e-mail: firstname.lastname@example.org.Uk). Deposited data may be accessed by the journal and checked as part of the refereeing process. If data are revised prior to publication, a replacement file should be sent to CCDC.
Characterization of new compounds
All new compounds should be fully characterized with relevant spectroscopic data. Microanalyses should be included whenever possible. Under appropriate circumstances, high-resolution mass spectra may serve in lieu of microanalysis, if accompanied by suitable NMR criteria for sample homogeneity.
Many Elsevier journals cite ''gene accession numbers'' in their running text and footnotes. Gene accession numbers refer to genes or DNA sequences about which further information can be found in the databases at the National Center for Biotechnical Information (NCBI) at the National Library of Medicine. Elsevier authors wishing to enable other scientists to use the accession numbers cited in their papers via links to these sources, should type this information in the following manner:
For each and every accession number cited in an article, authors should type the accession number in bold, underlined text. Letters in the accession number should always be capitalised. (See Example below). This combination of letters and format will enable Elsevier's typesetters to recognise the relevant texts as accession numbers and add the required link to GenBank's sequences.
Example: ''(GenBank accession nos. AI631510, AI631511, AI632198, and BF223228), a B-cell tumor from a chronic lymphatic leukemia (GenBank accession no. BE675048), and a T-cell lymphoma (GenBank accession no. AA361117)''. Authors are encouraged to check accession numbers used very carefully. An error in a letter or number can result in a dead link. In the final version of the printed article, the accession number text will not appear bold or underlined. In the final version of the electronic copy, the accession number text will be linked to the appropriate source in the NCBI databases enabling readers to go directly to that source from the article.Footnotes
Footnotes should appear at the bottom of the appropriate page and be indicated by the following symbols: asterisk, dagger, double dagger, section sign, paragraph, parallels.
Figures, schemes, and equations must be cited in the text and numbered in order of appearance with Arabic numerals. Other graphics, such as structures, do not need to be numbered, but please indicate in the text where these are to appear. All graphics (including chemical structures) must be provided at the actual size that they are to appear (single-column width is 8.4 cm, double-column width is 17.7 cm). Please arrange schematics so that they fill the column space (either single or double), so as not to leave a lot of unused white space. Please ensure that all illustrations within a paper are consistent in type, quality, and size. Legends should not be included as part of the graphic; instead all legends should be supplied at the end of the text.
To help authors provide actual size graphics, it is suggested that the following settings be used with CSC ChemDraw and ISIS Draw: font 10 pt Helvetica, chain angle 120°, bond spacing 18% of length, fixed length 10.08 pt (0.354 cm), bold width 1.4 pt (0.049 cm), line width 0.42 pt (0.015 cm), margin width 1.12 pt (0.040 cm), and hash spacing 1.75 pt (0.062 cm). Compound numbers should be in boldface. In order to accurately design schematics to print out at the proper width, the original drawing cannot exceed a column width of 8.4 cm (for single column) and 17.7 cm (for double column). Layout design is facilitated if authors submit their original artwork in the actual size to be published. Please save graphics as an Encapsulated PostScript file (EPS) or a Tagged Image File Format (TIFF), as well as the program the graphic was originally drawn in. For more details on the preparation and submission of artwork, please visit http://www.authors.elsevier.com.
Colour figures should be supplied in electronic format as JPEG files (minimum 300 dots per inch).
- In print: Colour figures may be printed in the journal at no charge to the author, provided that the editor considers the colour necessary to convey scientific information.
- On the Web: Any figure can appear free of charge in colour in the Web version of your article (e.g., on ScienceDirect), regardless of whether or not this is reproduced in colour in the printed version.
Legends for figures and schemes should be grouped together separately.
All tables should be cited in the text, and numbered in order of appearance with Arabic numerals. All table columns should have a brief explanatory heading and, where appropriate, units of measurement. Vertical lines should not be used. Footnotes to tables should be typed below the table and should be referred to by superscript letters. Each table should have a descriptive heading, which, together with the individual column headings, should make the table, as nearly as possible, self-explanatory. In setting up tabulations, authors are requested to keep in mind the column widths (8.4 cm and 17.7 cm), and to make the table conform to the limitations of these dimensions.
In the text, references should be indicated by superscript Arabic numerals which run consecutively through the paper and appear after any punctuation. Please ensure that all references are cited in the text and vice versa. The reference list should preferably contain only literature references, although other information (e.g., experimental details) can be placed in this section. Preferably, each reference should contain only one literature citation. Authors are expected to check the original source reference for accuracy. Journal titles should be abbreviated according to American Chemical Society guidelines (The ACS Style Guide; Dodd, J. S., Ed.; American Chemical Society: Washington DC, 1997). A list of currently accepted journal abbreviations may be found the journal home page at http://www.elsevier.com/locate/tetl. Formatting for common references are shown below.
1. Barton, D. H. R.; Yadav-Bhatnagar, N.; Finet, J.-P.; Khamsi, J. Tetrahedron Lett. 1987, 28, 3111.
2. Doe, J. S.; Smith, J. In Medicinal Chemistry; Roe, P., Ed.; Pergamon: Oxford, 1990; Vol. 1, pp 301 383.
3. Lyle, F. R. U.S. Patent 6,973,257, 1995; Chem. Abstr. 1995, 123, 2870.
4. Prasad, A.; Jackson, P. Abstracts of Papers, Part 2, 212th National Meeting of the American Chemical Society, Orlando, FL, Aug 25-29, 1996; American Chemical Society: Washington, DC, 1996; PMSE 189.
Citing and listing of Web references
As a minimum, the full URL should be given. Any further information, if known (author names, dates, reference to a source publication, etc.), should also be given. Web references can be listed separately (e.g., after the reference list) under a different heading if desired, or can be included in the reference list.
Most Elsevier journals have their reference template available in many of the most popular reference management software products. These include all products that support Citation Style Language styles, such as Mendeley and Zotero, as well as EndNote. Using the word processor plug-ins from these products, authors only need to select the appropriate journal template when preparing their article, after which citations and bibliographies will be automatically formatted in the journal's style. If no template is yet available for this journal, please follow the format of the sample references and citations as shown in this Guide.
Users of Mendeley Desktop can easily install the reference style for this journal by clicking the following link:
When preparing your manuscript, you will then be able to select this style using the Mendeley plug-ins for Microsoft Word or LibreOffice.
Standard ACS abbreviations should be used throughout the manuscript and are employed without periods. The preferred forms for some of the more commonly used abbreviations are mp, bp, °C, K, min, h, mL, &mgr;L, g, mg, &mgr;g, cm, mm, nm, mol, mmol, &mgr;mol, M, mM, &mgr;M, ppm, HPLC, TLC, GC, 1H NMR, GC-MS, HRMS, FABHRMS, UV, IR, EPR, ESR, DNase, ED50, ID50, IC50, LD50, im, ip, iv, mRNA, RNase, rRNA, tRNA, cpm, Ci, dpm, Vmax, Km, k, t1/2. All non-standard abbreviations should be defined following the first use of the abbreviation. For a detailed listing of standard abbreviations, see The ACS Style Guide; American Chemical Society: Washington, DC, 1997.
Software used as part of computer-aided drug/agent design (e.g., molecular modelling, QSAR, conformational analysis, molecular dynamics) should be readily available from accepted sources and the authors may specify where the software can be obtained. Assurance of the quality of the parameters employed for the relevant potential functions should be detailed in the manuscript.
Preparation of supplementary data
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To ensure that your submitted material is directly usable, please provide data in one of our recommended file formats. Supplementary data must be saved in files separate from those for the manuscript and figures, and all file names must be supplied. Supplementary files should either be referred to from within the text of your manuscript in the same way as for figures or tables, or their presence be indicated by adding a paragraph entitled "Supplementary data" at the end of the manuscript, detailing which data are supplied. In addition, authors should also provide a concise and descriptive caption for each file.
When supplying supplementary data, authors must state whether the data files are either (i) for online publication or (ii) to be used as an aid for the refereeing of the paper only. All supplementary data will be subject to peer review. For more detailed instructions, please visit Elsevier's Author Gateway at http://authors.elsevier.com, and click on "Artwork instructions", then "Multimedia files".
Elsevier encourages authors to connect articles with external databases, giving readers access to relevant databases that help to build a better understanding of the described research. Please refer to relevant database identifiers using the following format in your article: Database: xxxx (e.g., TAIR: AT1G01020; CCDC: 734053; PDB: 1XFN). More information and a full list of supported databases.
The journal encourages authors to create an AudioSlides presentation with their published article. AudioSlides are brief, webinar-style presentations that are shown next to the online article on ScienceDirect. This gives authors the opportunity to summarize their research in their own words and to help readers understand what the paper is about. More information and examples are available. Authors of this journal will automatically receive an invitation e-mail to create an AudioSlides presentation after acceptance of their paper.
You can enrich your article with visual representations, links and details for those chemical structures that you define as the main chemical compounds described. Please follow the instructions to learn how to do this.
This journal enables you to show an Interactive Plot with your article by simply submitting a data file. Full instructions.
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