Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding and/or design, will also be considered favorably. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single molecule analysis of biological mechanisms are welcome. In general, the editors encourage submission of structural studies that are validated by additional experimental systems that address structure-activity relationships, and will not consider studies that solely report structural information unless the structure under investigation is of exceptional and broad interest.
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